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001-es BibID:BIBFORM099030
035-os BibID:(Scopus)85122905153 (WOS)000754954100007
Első szerző:Képes Zita (orvos)
Cím:Homocysteine-related alterations of [18F]FDG brain pattern in metabolic diseases / Zita Képes, Csaba Aranyi, Attila Forgács, Ferenc Nagy, Kornél Kukuts, Regina Esze, Sándor Somodi, Miklós Káplár, József Varga, Miklós Emri, Ildikó Garai
Dátum:2021
ISSN:1790-5427
Megjegyzések:Since hyperhomocysteinaemia (HHcys) is implicated as a risk factor for the development of neurodegeneration, and is associated with the development of metabolic diseases, we aimed at analysing the effect of homocysteine (Hcys) on regional fluorine-18-fluorodeoxyglucose (18F-FDG) brain metabolism in 51 controlled type 2 diabetic and in 48 non-DM obese participants. Plasma Hcys levels were measured by an immunoassay. Homocysteine-related 18F-FDG regional brain metabolism was evaluated applying 18F-FDG PET/CT using magnetic resonance imaging (MRI)-based brain template for Statistical Parametric Mapping (SPM) analysis. Homocysteine-related decreased 18F-FDG uptake was shown in the right middle temporal gyrus in the whole population. Diabetics with Hcys above the reference limit expressed decreased glucose metabolism in the left calcarine cortex compared to the obese with HHcys. Regional metabolic alterations evoked on the basis of HHcys draw attention to the potential risk of neurodegeneration caused by metabolic disturbances.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Diabetes
Obesity
(18)-F-FDG PET/CT
Homocysteine
Neurodegeneration
Megjelenés:Hellenic Journal of Nuclear Medicine. - 24 : 3 (2021), p. 222-227. -
További szerzők:Aranyi Sándor Csaba (1988-) (programtervező informatikus) Forgács Attila (1985-) (fizikus) Nagy Ferenc (1984-) (fizikus) Kukuts Kornél Esze Regina Somodi Sándor (1977-) (belgyógyász) Káplár Miklós (1965-) (belgyógyász, diabetológus) Varga József (1955-) (fizikus) Emri Miklós (1962-) (fizikus) Garai Ildikó (1966-) (radiológus)
Pályázati támogatás:National Grant No. GINOP-2.1.1-15-2015-00609
GINOP
National Brain Research Program No. 2017-1.2.1-NKP-2017-00002
Egyéb
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
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2.

001-es BibID:BIBFORM091840
Első szerző:Képes Zita (orvos)
Cím:Examination of brain perfusion and metabolism in metabolic diseases (focusing on diabetes and obesity) / Z. Képes, J. Varga, F. Nagy, K. Kukuts, M. Emri, M. Káplár, Cs. Aranyi, I. Garai
Dátum:2019
Tárgyszavak:Orvostudományok Klinikai orvostudományok nem besorolt
egyéb
További szerzők:Varga József (1955-) (fizikus) Nagy Ferenc (1984-) (fizikus) Kukuts Kornél Emri Miklós (1962-) (fizikus) Káplár Miklós (1965-) (belgyógyász, diabetológus) Aranyi Sándor Csaba (1988-) (programtervező informatikus) Garai Ildikó (1966-) (radiológus)
Pályázati támogatás:GINOP-2.1.1-15-2015-00609
GINOP
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
Borító:

3.

001-es BibID:BIBFORM091785
035-os BibID:(cikkazonosító)3 (WOS)000672838300001 (Scopus)85100999105
Első szerző:Képes Zita (orvos)
Cím:Glucose-level dependent brain hypometabolism in type 2 diabetes mellitus and obesity / Z. Képes, Cs. Aranyi, A. Forgács, F. Nagy, K. Kukuts, Zs. Hascsi, R. Esze, S. Somodi, M. Káplár, J. Varga, M. Emri, I. Garai
Dátum:2021
Megjegyzések:Glucose-level dependent brain hypometabolism in type 2 diabetes mellitus and obesity Background: Metabolic syndrome and its individual components lead to wide-ranging consequences, many of which affect the central nervous system. In this study, we compared the [18F]FDG regional brain metabolic pattern of participants with type 2 diabetes mellitus (T2DM) and non-DM obese individuals. Methods: In our prospective study 51 patients with controlled T2DM (ages 50.6 ? 8.0 years) and 45 non-DM obese participants (ages 52.0 ? 9.6 years) were enrolled. Glucose levels measured before PET/CT examination (pre-PET glucose) as well as laboratory parameters assessing glucose and lipid status were determined. NeuroQ application (NeuroQTM 3.6, Syntermed, Philips) was used to evaluate regional brain metabolic differences. [18F]FDG PET/CT (AnyScan PC, Mediso) scans, estimating brain metabolism were transformed to MNI152 brain map after T1 registration and used for SPM-based group comparison of brain metabolism corrected for pre-PET glucose, and correlation analysis with laboratory parameters. Results: NeuroQ analysis did not reveal significant regional metabolic defects in either group. Voxel-based group comparison revealed significantly (pFWE<0.05) decreased metabolism in the region of the precuneus and in the right superior frontal gyrus (rSFG) in the diabetic group as compared to the obese patients. Data analysis corrected for pre-PET glucose level showed a hypometabolic difference only in the rSFG in T2DM. Voxel-based correlation analysis showed significant negative correlation of the metabolism in the following brain regions with pre-PET glucose in diabetes: precuneus, left posterior orbital gyrus, right calcarine cortex and right orbital part of inferior frontal gyrus; while in the obese group only the right rolandic (pericentral) operculum proved to be sensitive to pre-PET glucose level. Conclusions: To our knowledge this is the first study to perform pre-PET glucose level corrected comparative analysis of brain metabolism in T2DM and obesity. We also examined the pre-PET glucose level dependency of regional cerebral metabolism in the two groups separately. Large-scale future studies are warranted to perform further correlation analysis with the aim of determining the effects of metabolic disturbances on brain metabolism. Keywords: [18F]FDG, metabolism, brain, type 2 diabetes mellitus, obesity
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
[18F]FDG
metabolism
brain
type 2 diabetes mellitus
obesity
Megjelenés:European Journal of Hybrid Imaging. - 5 : 1 (2021), p. 1-15. -
További szerzők:Aranyi Sándor Csaba (1988-) (programtervező informatikus) Forgács Attila (1985-) (fizikus) Nagy Ferenc (1984-) (fizikus) Kukuts Kornél Hascsi Zsolt Esze Regina Somodi Sándor (1977-) (belgyógyász) Káplár Miklós (1965-) (belgyógyász, diabetológus) Varga József (1955-) (fizikus) Emri Miklós (1962-) (fizikus) Garai Ildikó (1966-) (radiológus)
Pályázati támogatás:GINOP-2.1.1-15-2015-00609
GINOP
National Brain Research Program No. 2017-1.2.1-NKP-2017-00002.
Egyéb
Internet cím:Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
Borító:

4.

001-es BibID:BIBFORM087278
035-os BibID:(WoS)000492444403175
Első szerző:Képes Zita (orvos)
Cím:Examinantion of brain perfusion and metabolism in metabolic diseases (focusing on diabetes and obesity) / Zita Képes, J. Varga, F. Nagy, M. Emri, M. Káplár, Cs. Aranyi, I. Garai
Dátum:2019
ISSN:1619-7070 1619-7089
Megjegyzések:Aim/Introduction: Microcircular alterations that could already be observed in prediabetic state (obesity and insulin resistance) are supposed to have significant role in the developement of the consequences of diabetes mellitus. The main aim of our study was to compare the cerebrovascular microcirculation and metabolism of obese patients and patients suffering from type 2 diabetes mellitus. Materials and Methods: In our prospective study 57 patients with controlled type 2 diabetes mellitus (52?9,6 years) and 46 obese patients (50,6?7,9 years) were enrolled. BMI proved to be 34,06?5,94 in the diabetic group while it was 38,14?6,06 among the obese patients. Dynamic Tc99m-HMPAO study (AnyScanFlex, Mediso) was performed for evaluation of hemispheral perfusion using Patlak analysis. Then tomographic imaging was carried out at rest condition. Brain metabolism was estimated applying 18F-FDG PET/CT (AnyScan PC, Mediso). FDG and HMPAO scans were transformed to MNI152 brain map after T1 registration and used for SPM (Statistical Parametric Mapping) analysis. NeuroQ application (Syntermed) was used to evaluate regional differences. Statistical analysis (Shapiro-Wilk, Wilcoxon, Spearman correlation) was applied for assessment of group differences. Results: Hemispheral perfusion calculated with Patlak analysis showed positive correlation with BMI (rho=0.35, p=0.016). There were no significant differences in hemispheral and regional perfusion in T2DM and the obese group. However, we found hypometabolism in right and left cuneus (Br17) in T2DM with SPM analysis. NeuroQ analysis did not reveal significant regional perfusion or metabolic defects in either groups. Conclusion: Based on current literature hypometabolism in the region of the cuneus is a characteristic feature of neurodegenerative diseases. The reason why no significant perfusion defects were found could be explained by the fact that the enrolled diabetics were therapeutically well managed. Unexpected significant correlation with BMI is unclear, further investigation is required. References: None
Tárgyszavak:Orvostudományok Klinikai orvostudományok idézhető absztrakt
folyóiratcikk
Megjelenés:European Journal of Nuclear Medicine and Molecular Imaging. - 46 : S1 (2019), p. S399-S400. -
További szerzők:Varga József (1955-) (fizikus) Nagy Ferenc (1984-) (fizikus) Emri Miklós (1962-) (fizikus) Káplár Miklós (1965-) (belgyógyász, diabetológus) Aranyi Sándor Csaba (1988-) (programtervező informatikus) Garai Ildikó (1966-) (radiológus)
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
DOI
Borító:

5.

001-es BibID:BIBFORM087279
035-os BibID:(WoS)000492444401187
Első szerző:Mikó Márton
Cím:Alterations of peripherial micorcirculation in Diabetes mellitus and Obesity / M. Mikó, J. Varga, F. Nagy, M. Emri, M. Káplár, A. Forgács, I. Garai
Dátum:2019
ISSN:1619-7070 1619-7089
Megjegyzések:Aim/Introduction: The number of people with obesity and diabetes is continously growing. These are important metabolic drivers of cerebrovascular and cardiovascular diseases as well as peripheral neuropathy. Damage to the microcirculation is the basis for these conditions.In our study we investigated peripheral perfusion in these two metabolic diseases and its correlation with laboratory parameters and neuropathy. Materials and Methods: In this prospective study, 57 patients with controlled type 2 diabetes mellitus (T2DM) (mean age:52?9.6) and 46 patients with obesity (50.6?7.9) were recruited. BMI was 34.1?5.9 in T2DM and 38.1?6.1 in the obese group. Quantitative Tc99m HMPAO (Mediradiopharma, Hungary) SPECT/CT (AnyscanFlexSC, Mediso, Hungary) studies were performed to assess peripheral microcirculation in the legs. Patients with known symptomatic peripheral circulation abnormalities were excluded from the study. For the SUVmean calculation, fixed sized spheric VOIs (volume of interest) were drawn in the calf musculature bilaterally. Neurometer testing (NM-01/CPT) was used for evaluating sub-clinical peripheral nerve dysfunction. For statistical analysis, Shapiro normality test, Wilcoxon test and paired Spearman correlation was done. Results: There were no significant differences of calculated SUVmean values in right and left legs in both groups, neither were there any in neurometer testing. However, leg perfusion was significantly lower in the diabetic group predominantly on the left side (p=0.015 right leg, p=0,00065 left leg). Neurometer data showed correlation with HBA1C in the diabetic group, but none with leg perfusion. There was no correlation between neurometer test results and leg perfusion in the obese group. We also investigated the correlation of BMI, age and leg perfusion. BMI showed positive correlation with mean leg perfusion (rho=0,36, p=0,001) and no correlation with age was found. Conclusion: Quantitative leg perfusion SPECT/CT with Tc99m HMPAO is a sensitive method for evaluating subclinical perfusion abnormalities, providing complementary information for early assessment of peripheral neuropathy in diabetes. Further investigation is needed to understand the background of correlation of leg perfusion and BMI. References: None
Tárgyszavak:Orvostudományok Klinikai orvostudományok idézhető absztrakt
folyóiratcikk
Megjelenés:European Journal of Nuclear Medicine and Molecular Imaging. - 46 : S1 (2019), p. S204-S205. -
További szerzők:Varga József (1955-) (fizikus) Nagy Ferenc (1984-) (fizikus) Emri Miklós (1962-) (fizikus) Káplár Miklós (1965-) (belgyógyász, diabetológus) Forgács Attila (1985-) (fizikus) Garai Ildikó (1966-) (radiológus)
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
DOI
Borító:
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