CCL

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001-es BibID:BIBFORM082977
035-os BibID:(WoS)000453593000019 (Scopus)85054365983
Első szerző:Moreira, Thais Garcias
Cím:CLA-supplemented diet accelerates experimental colorectal cancer by inducing TGF-β-producing macrophages and T cells / T. G. Moreira, L. S. Horta, A. C. Gomes-Santos, R. P. Oliveira, N. M. G. P. Queiroz, D. Mangani, B. Daniel, A. T. Vieira, S. Liu, A. M. Rodrigues, D. A. Gomes, G. Gabriely, E. Ferreira, H. L. Weiner, R. M. Rezende, L. Nagy, A. M. C. Faria
Dátum:2019
ISSN:1933-0219 1935-3456
Megjegyzések:Conjugated linoleic acid (CLA) has been shown to activate the nuclear receptor PPAR-γ and modulate metabolic and immune functions. Despite the worldwide use of CLA dietary supplementation, strong scientific evidence for its proposed beneficial actions are missing. We found that CLA-supplemented diet reduced mucosal damage and inflammatory infiltrate in the dextran sodium sulfate (DSS)-induced colitis model. Conditional deletion of PPAR-γ in macrophages from mice supplemented with CLA diet resulted in loss of this protective effect of CLA, suggesting a PPAR-γ-dependent mechanism mediated by macrophages. However, CLA supplementation significantly worsened colorectal tumor formation induced by azoxymethane and DSS by inducing macrophage and T-cell-producing TGF-β via PPAR-γ activation. Accordingly, either macrophage-specific deletion of PPAR-γ or in vivo neutralization of latency-associated peptide (LAP, a membrane-bound TGF-β)-expressing cells abrogated the protumorigenic effect of CLA. Thus, the anti-inflammatory properties of CLA are associated with prevention of colitis but also with development of colorectal cancer.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:Mucosal Immunology. - 12 : 1 (2019), p. 188-199. -
További szerzők:Horta, Laila Sampaio Gomes-Santos, Ana Cristina Oliveira, R. P. Queiroz, N. M. G. P. Mangani, D. Dániel Bence (1987-) (molekuláris biológus) Vieira, A. T. Liu, S. Rodrigues, A. M. Gomes, D. A. Gabriely, G. Ferreira, E. Weiner, H. L. Rezende, Rafael Machado Nagy L. Faria, Ana Maria Caetano
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