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001-es BibID:	BIBFORM068548
Első szerző:	Kovács Árpád (kardiológus)
Cím:	Is enhancing cGMP-PKG signalling a promising therapeutic target for heart failure with preserved ejection fraction? / Kovács Á., Alogna A., Post H., Hamdani N.
Dátum:	2016
ISSN:	1568-5888 1876-6250
Megjegyzések:	Heart failure with preserved ejection fraction, i.e. HFpEF, is highly prevalent in ageing populations, accounting for more than 50?% of all cases of heart failure in Western societies, and is closely associated with comorbidities such as obesity, diabetes and arterial hypertension. However, all large multicentre trials of potential HFpEF treatments conducted to date have failed to produce positive outcomes. These disappointing results suggest that a 'one size fits all' strategy may be ill-suited to HFpEF and support the use of tailored, personalised therapeutic approaches with specific treatments designed for specific comorbidity-related HFpEF phenotypes. The accumulation of a multitude of cardiovascular comorbidities over time leads to increased systemic inflammation, oxidative stress and coronary microvascular endothelial inflammation, eventually resulting in degradation of cyclic guanosine monophosphate (cGMP) via multiple pathways, thereby reducing protein kinase G (PKG) activity. The importance of cGMP-PKG pathway modulation is supported by growing evidence that suggests that this pathway may be a promising therapeutic target, evidence that is mainly based on its role in the phosphorylation of the giant cytoskeletal protein titin. This review will focus on the preclinical and early clinical evidence in the field of cGMP-enhancing therapies and PKG activation.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban Comorbidities Diastolic stiffness Heart failure with preserved ejection fraction Oxidative stress Titin cGMP-PKG
Megjelenés:	Netherlands Heart Journal 24 : 4 (2016), p. 268-274. -
További szerzők:	Alogna, A. Post, H. Hamdani, Nazha
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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