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001-es BibID:	BIBFORM076738
035-os BibID:	(WOS)000453351000007 (Scopus)85057166811
Első szerző:	Fülöp Gábor Áron (általános orvos)
Cím:	Nrf2 deficiency in aged mice exacerbates cellular senescence promoting cerebrovascular inflammation / Gabor A. Fulop, Tamas Kiss, Stefano Tarantini, Priya Balasubramanian, Andriy Yabluchanskiy, Eszter Farkas, Ferenc Bari, Zoltan Ungvari, Anna Csiszar
Dátum:	2018
ISSN:	2509-2715 2509-2723
Megjegyzések:	Aging-induced pro-inflammatory phenotypic alterations of the cerebral vasculature critically contribute to the pathogenesis of vascular cognitive impairment. Cellular senescence is a fundamental aging process that promotes inflammation; however, its role in cerebrovascular aging remains unexplored. The present study was undertaken to test the hypothesis that advanced aging promotes cellular senescence in the cerebral vasculature. We found that in cerebral arteries of 24-month-old mice, expression of molecular markers of senescence (p16INK4a, p21) is upregulated as compared to that in young controls. Induction of senescence programs in cerebral arteries is associated by an upregulation of a wide range of inflammatory cytokines and chemokines, which are known to contribute to the senescence-associated secretory phenotype (SASP) in vascular cells. Age-related cerebrovascular senescence and inflammation are associated with neuroinflammation, as shown by the molecular footprint of microglia activation in the hippocampus. Genetic depletion of the pro-survival/anti-aging transcriptional regulator Nrf2 exacerbated age-related induction of senescence markers and inflammatory SASP factors and resulted in a heightened inflammatory status of the hippocampus. In conclusion, our studies provide evidence that aging and Nrf2 dysfunction promote cellular senescence in cerebral vessels, which may potentially cause or exacerbate age-related pathology.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk Endothelial dysfunction Senescence VCID Vascular aging Vascular cognitive impairment
Megjelenés:	GeroScience. - 40 : 5-6 (2018), p. 513-521. -
További szerzők:	Kiss Tamás Tarantini, Stefano Balasubramanian, Priya Yabluchanskiy, Andriy Farkas Eszter Bari Ferenc Ungvári Zoltán Csiszár Anna
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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