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001-es BibID:	BIBFORM085461
035-os BibID:	(WOS)000412737500001 (Scopus)85028747573
Első szerző:	Csiszár Anna
Cím:	Hypertension impairs neurovascular coupling and promotes microvascular injury : role in exacerbation of Alzheimer's disease / Csiszar Anna, Tarantini Stefano, Fülöp Gábor A., Kiss Tamas, Valcarcel-Ares M. Noa, Galvan Veronica, Ungvari Zoltan, Yabluchanskiy Andriy
Dátum:	2017
ISSN:	2509-2715 2509-2723
Megjegyzések:	Hypertension in the elderly substantially increases both the risk of vascular cognitive impairment (VCI) and Alzheimer's disease (AD); however, the underlying mechanisms are not completely understood. This review discusses the effects of hypertension on structural and functional integrity of cerebral microcirculation, including hypertension-induced alterations in neurovascular coupling responses, cellular and molecular mechanisms involved in microvascular damage (capillary rarefaction, blood-brain barrier disruption), and the genesis of cerebral microhemorrhages and their potential role in exacerbation of cognitive decline associated with AD. Understanding and targeting the hypertension-induced cerebromicrovascular alterations that are involved in the onset and progression of AD and contribute to cognitive impairment are expected to have a major role in preserving brain health in high-risk older individuals.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk Functional hyperemia Neurovascular coupling Angiotensin II High blood pressure Hypertension VCID Endothelial dysfunction Microcirculation Alzheimer's disease
Megjelenés:	GeroScience. - 39 : 4 (2017), p. 359-372. -
További szerzők:	Tarantini, Stefano Fülöp Gábor Áron (1988-) (általános orvos) Kiss Tamás Valcarcel Ares, Marta Noa Galvan, Veronica Ungvári Zoltán Yabluchanskiy, Andriy
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM085460
035-os BibID:	(WOS)000412737500010 (Scopus)85020091346
Első szerző:	Tarantini, Stefano
Cím:	Demonstration of impaired neurovascular coupling responses in TG2576 mouse model of Alzheimer's disease using functional laser speckle contrast imaging / Tarantini Stefano, Fulop Gabor A., Kiss Tamas, Farkas Eszter, Zölei-Szénási Dániel, Galvan Veronica, Toth Peter, Csiszar Anna, Ungvari Zoltan, Yabluchanskiy Andriy
Dátum:	2017
ISSN:	2509-2715 2509-2723
Megjegyzések:	Increasing evidence from epidemiological, clinical, and experimental studies indicates that cerebromicrovascular dysfunction and microcirculatory damage play critical roles in the pathogenesis of many types of dementia in the elderly, including both vascular cognitive impairment (VCI) and Alzheimer's disease. Vascular contributions to cognitive impairment and dementia (VCID) include impairment of neurovascular coupling responses/functional hyperemia (Bneurovascular uncoupling^). Due to the growing interest in understanding and pharmacologically targeting pathophysiological mechanisms of VCID, there is an increasing need for sensitive, easy-to-establish methods to assess neurovascular coupling responses. Laser speckle contrast imaging (LSCI) is a technique that allows rapid and minimally invasive visualization of changes in regional cerebromicrovascular blood perfusion. This type of imaging technique combines high resolution and speed to provide great spatiotemporal accuracy to measure moment-to-moment changes in cerebral blood flow induced by neuronal activation. Here, we provide detailed protocols for the successful measurement in neurovascular coupling responses in anesthetized mice equipped with a thinned-skull cranial window using LSCI. This method can be used to evaluate the effects of anti-aging or anti-AD treatments on cerebromicrovascular health.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk Neurovascular coupling Functional hyperemia Laser speckle contrast imaging Laser speckle contrast analysis LASCA Laser speckle imaging LSI
Megjelenés:	GeroScience. - 39 : 4 (2017), p. 465-473. -
További szerzők:	Fülöp Gábor Áron (1988-) (általános orvos) Kiss Tamás Farkas Eszter Zölei-Szénási Dániel Galvan, Veronica Tóth Péter (sebész) Csiszár Anna Ungvári Zoltán Yabluchanskiy, Andriy
Pályázati támogatás:	K111923 OTKA EFOP-3.6.1-16- 2016-00008 EFOP
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
Borító:
Saját polcon: