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001-es BibID:	BIBFORM099943
035-os BibID:	(WOS)000469877700003 (Scopus)85066471327
Első szerző:	Csípő Tamás
Cím:	Age-related decline in peripheral vascular health predicts cognitive impairment / Csipo Tamas, Lipecz Agnes, Fulop Gabor A., Hand Rachel A., Ngo Bich-Thy N., Dzialendzik Mikita, Tarantini Stefano, Balasubramanian Priya, Kiss Tamas, Yabluchanska Valeriya, Silva-Palacios Federico, Courtney Donald L., Dasari Tarun W., Sorond Farzaneh, Sonntag William E., Csiszar Anna, Ungvari Zoltan, Yabluchanskiy Andriy
Dátum:	2019
ISSN:	2509-2715 2509-2723
Megjegyzések:	Preclinical studies demonstrate that generalized endothelial cell dysfunction and microvascular impairment are potentially reversible causes of age-related vascular cognitive impairment and dementia (VCID). The present study was designed to test the hypothesis that severity of age-related macro- and microvascular dysfunction measured in the peripheral circulation is an independent predictor of cognitive performance in older adults. In this study, we enrolled 63 healthy individuals into young (< 45 years old) and aged (> 65 years old) groups. We used principal component analysis (PCA) to construct a comprehensive peripheral vascular health index (VHI) encompassing peripheral microvascular reactivity, arterial endothelial function, and vascular stiffness, as a marker of aging-induced generalized vascular dysfunction. Peripheral macrovascular and microvascular endothelial function were assessed using flow-mediated dilation (FMD) and laser speckle contrast imaging tests. Pulse waveform analysis was used to evaluate the augmentation index (AIx), a measure of arterial stiffness. Cognitive function was measured using a panel of CANTAB cognitive tests, and PCA was then applied to generate a cognitive impairment index (CII) for each participant. Aged subjects exhibited significantly impaired macrovascular endothelial function (FMD, 5.6 ? 0.7% vs. 8.3 ? 0.6% in young, p = 0.0061), increased arterial stiffness (AIx 29.3 ? 1.8% vs 4.5 ? 2.6% in young, p < 0.0001), and microvascular dysfunction (2.8 ? 0.2 vs 3.4 ? 0.1-fold change of perfusion in young, p = 0.032). VHI showed a significant negative correlation with age (r = - 0.54, p < 0.0001) and CII significantly correlated with age (r = 0.79, p < 0.0001). VHI significantly correlated with the CII (r = - 0.46, p = 0.0003). A decline in peripheral vascular health may reflect generalized vascular dysfunction and predict cognitive impairment in older adults.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk Aging Endothelial function Cognitive impairment Microvascular dysfunction VCID
Megjelenés:	GeroScience. - 41 : 2 (2019), p. 125-136. -
További szerzők:	Lipécz Ágnes Fülöp Gábor Áron (1988-) (általános orvos) Hand, Rachel A. Ngo, Bich-Thy N. Dzialendzik, Mikita Tarantini, Stefano Balasubramanian, Priya Kiss Tamás (1950-) (vegyész) Yabluchanska, Valeriya Silva-Palacios, Federico Courtney, Donald L. Dasari, Tarun W. Sorond, Farzaneh A. Sonntag, William E. Csiszár Anna Ungvári Zoltán Yabluchanskiy, Andriy
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM099949
035-os BibID:	(WOS)000433040100011 (Scopus)85042217471
Első szerző:	Tarantini, Stefano
Cím:	Correction to : pharmacologically induced impairment of neurovascular coupling responses alters gait coordination in mice / Tarantini Stefano, Yabluchanskiy Andriy, Fülöp Gábor A., Hertelendy Peter, Noa Valcarcel-Ares M., Kiss Tamas, Bagwell Jonathan M., O'Connor Daniel, Farkas Eszter, Sorond Farzaneh, Csiszar Anna, Ungvari Zoltan
Dátum:	2018
ISSN:	2509-2715 2509-2723
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk
Megjelenés:	GeroScience. - 40 : 2 (2018), p. 219-219. -
További szerzők:	Yabluchanskiy, Andriy Fülöp Gábor Áron (1988-) (általános orvos) Hertelendy Péter Valcarcel Ares, Marta Noa Kiss Tamás (1950-) (vegyész) Bagwell, Jonathan M. O'Connor, Daniel Farkas Eszter Sorond, Farzaneh A. Csiszár Anna Ungvári Zoltán
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM099928
035-os BibID:	(WOS)000516499100001 (Scopus)85078289607
Első szerző:	Yabluchanskiy, Andriy
Cím:	Pharmacological or genetic depletion of senescent astrocytes prevents whole brain irradiation-induced impairment of neurovascular coupling responses protecting cognitive function in mice / Yabluchanskiy Andriy, Tarantini Stefano, Balasubramanian Priya, Kiss Tamas, Csipo Tamas, Fülöp Gábor A., Lipecz Agnes, Ahire Chetan, DelFavero Jordan, Nyul-Toth Adam, Sonntag William E., Schwartzman Michal L., Campisi Judith, Csiszar Anna, Ungvari Zoltan
Dátum:	2020
ISSN:	2509-2715 2509-2723
Megjegyzések:	Whole brain irradiation (WBI, also known as whole brain radiation therapy or WBRT) is a mainstream therapy for patients with identifiable brain metastases and as a prophylaxis for microscopic malignancies. WBI accelerates brain aging, causing progressive cognitive dysfunction in ~ 50% of surviving patients, thus compromising quality of life. The mechanisms responsible for this WBI side effect remain obscure, and there are no effective treatments or prevention strategies. Here, we test the hypothesis that WBI induces astrocyte senescence, which contributes to impaired astrocytic neurovascular coupling (NVC) responses and the genesis of cognitive decline. To achieve this goal, we used transgenic p16-3MR mice, which allows the detection and selective elimination of senescent cells. We subjected these mice to a clinically relevant protocol of fractionated WBI (5 Gy twice weekly for 4 weeks). WBI-treated and control mice were tested for spatial memory performance (radial arm water maze), astrocyte-dependent NVC responses (whisker-stimulation-induced increases in cerebral blood flow, assessed by laser speckle contrast imaging), NVC-related gene expression, astrocytic release of eicosanoid gliotransmitters and the presence of senescent astrocytes (by flow cytometry, immunohistochemistry and gene expression profiling) at 6 months post-irradiation. WBI induced senescence in astrocytes, which associated with NVC dysfunction and impaired performance on cognitive tasks. To establish a causal relationship between WBI-induced senescence and NVC dysfunction, senescent cells were depleted from WBI-treated animals (at 3 months post-WBI) by genetic (ganciclovir treatment) or pharmacological (treatment with the BCL-2/BCL-xL inhibitor ABT263/Navitoclax, a known senolytic drug) means. In WBI-treated mice, both treatments effectively eliminated senescent astrocytes, rescued NVC responses, and improved cognitive performance. Our findings suggest that the use of senolytic drugs can be a promising strategy for preventing the cognitive impairment associated with WBI.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk Aging Dementia Functional hyperemia Radiation Senescence Vascular cognitive impairment WBI WBRT Whole brain radiation therapy
Megjelenés:	GeroScience. - 42 : 2 (2020), p. 409-428. -
További szerzők:	Tarantini, Stefano Balasubramanian, Priya Kiss Tamás (1950-) (vegyész) Csípő Tamás (1990-) Fülöp Gábor Áron (1988-) (általános orvos) Lipécz Ágnes Ahire, Chetan DelFavero, Jordan Nyúl-Tóth Ádám Sonntag, William E. Schwartzman, Michal L. Campisi, Judith Csiszár Anna Ungvári Zoltán
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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