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001-es BibID:	BIBFORM116181
035-os BibID:	(Scopus)85176106626
Első szerző:	Rossi, Giuseppe
Cím:	Age, successive waves, immunization, and mortality in elderly COVID-19 hematological patients : EPICOVIDEHA findings / Giuseppe Rossi, Jon Salmanton-García, Chiara Cattaneo, Francesco Marchesi, Julio Dávila-Valls, Sonia Martín-Pérez, Federico Itri, Alberto López-García, Andreas Glenthøj, Maria Gomes da Silva, Caroline Besson, Monia Marchetti, Barbora Weinbergerová, Ozren Jaksic, Moraima Jiménez, Yavuz M. Bilgin, Jaap Van Doesum, Francesca Farina, Pavel Žák, Luisa Verga, Graham P. Collins, Valentina Bonuomo, Jens Van Praet, Marcio Nucci, Stef Meers, Ildefonso Espigado, Nicola S. Fracchiolla, Toni Valković, Christian Bjørn Poulsen, Natasha Čolović, Giulia Dragonetti, Marie-Pierre Ledoux, Carlo Tascini, Caterina Buquicchio, Ola Blennow, Francesco Passamonti, Marina Machado, Jorge Labrador, Rafael F. Duarte, Martin Schönlein, Lucia Prezioso, Iker Falces-Romero, Austin Kulasekararaj, Carolina Garcia-Vidal, Noemí Fernández, Ghaith Abu-Zeinah, Irati Ormazabal-Vélez, Tatjana Adžić-Vukičević, Klára Piukovics, Igor Stoma, Annarosa Cuccaro, Gabriele Magliano, Tomáš Szotkowski, Tomás José González-López, Shaimaa El-Ashwah, Rui Bergantim, Uluhan Sili, Johan Maertens, Fatih Demirkan, Cristina De Ramón, Verena Petzer, Maria Ilaria Del Principe, Milan Navrátil, Michelina Dargenio, Guldane Cengiz Seval, Michail Samarkos, Zdeněk Ráčil, László Imre Pinczés, Tobias Lahmer, Alessandro Busca, Gustavo-Adolfo Méndez, Antonio Vena, Monika M. Biernat, Maria Merelli, Maria Calbacho, Aleksandra Barać, Martina Bavastro, Alessandro Limongelli, Osman Ilhan, Dominik Wolf, Gökçe Melis Çolak, Ramón García-Sanz, Ziad Emarah, Bojana Mišković, Stefanie K. Gräfe, Miloš Mladenović, Tommaso Francesco Aiello, Lucía Núñez-Martín-Buitrago, Anna Nordlander, Elena Arellano, Giovanni Paolo Maria Zambrotta, Emanuele Ammatuna, Alba Cabirta, Maria Vittoria Sacchi, Raquel Nunes Rodrigues, Ditte Stampe Hersby, Michaela Hanakova, Laman Rahimli, Raul Cordoba, Oliver A. Cornely, Livio Pagano
Dátum:	2023
ISSN:	1201-9712
Megjegyzések:	Objectives: Elderly patients with hematologic malignancies face the highest risk of severe COVID-19 outcomes. The infection's impact on different age groups remains unstudied in detail. Methods: We analyzed elderly patients (age groups: 65-70, 71-75, 76-80, and >80 years old) with hematologic malignancies included in the EPICOVIDEHA registry between January 2020 and July 2022. Univariable and multivariable Cox regression models were conducted to identify factors influencing death in COVID-19 patients with hematological malignancy. Results: The study included data from 3,603 elderly patients (aged 65 or older) with hematological malignancy, with a majority being male (58.1%) and a significant proportion having comorbidities. The patients were divided into four age groups, and the analysis assessed COVID-19 outcomes, vaccination status, and other variables in relation to age and pandemic waves. The 90-day survival rate for patients with COVID-19 was 71.2%, with significant differences between groups. The pandemic waves had varying impacts, with the first wave affecting patients over 80 years old, the second being more severe in 65-70, and the third being the least severe in all age groups. Factors contributing to 90-day mortality included age, comorbidities, lymphopenia, active malignancy, acute leukemia, less than three vaccine doses, severe COVID-19, and using only corticosteroids as treatment. Conclusion: These data underscore the heterogeneity of elderly hematological patients, highlight the different impacts of COVID-19 waves and the pivotal importance of vaccination, and may help in planning future healthcare efforts. ? 2023 The Author(s)
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk COVID-19 Elderly Hematological malignancy High-risk patient SARS-CoV-2
Megjelenés:	International Journal Of Infectious Diseases. - 137 (2023), p. 98-110. -
További szerzők:	Salmanton-García, Jon Cattaneo, Chiara Marchesi, Francesco Dávila-Valls, Julio Martín-Pérez, Sonia Itri, Federico López-García, Alberto Glenthj, Andreas Gomes Da Silva, Maria Besson, Caroline Marchetti, Monia Weinbergerová, Barbora Jaksic, Ozren Jiménez, Moraima Bilgin, Yavuz M. van Doesum, Jaap Farina, Francesca Žák, Pavel Verga, Luisa Collins, Graham Bonuomo, Valentina van Praet, Jens Nucci, Marcio Meers, Stef Espigado, Ildefonso Fracchiolla, Nicola S. Valkovic, Toni Poulsen, Christian Bjørn Colovic, Natasa Dragonetti, Giulia Ledoux, Marie-Pierre Tascini, Carlo Buquicchio, Caterina Blennow, Ola Passamonti, Francesco Machado, Marina Labrador, Jorge Duarte, Rafael F. Schönlein, Martin Prezioso, Lucia Falces-Romero, Iker Kulasekararaj, Austin Garcia-Vidal, Carolina Fernández, Noemí Abu-Zeinah, Ghaith Ormazabal-Vélez, Irati Adžić-Vukičević, Tatjana Piukovics Klára Stoma, Igor Cuccaro, Annarosa Magliano, Gabriele Szotkowski, Tomáš González-López, Tomás José El-Ashwah, Shaimaa Bergantim, Rui Sili, Uluhan Maertens, Johan Demirkan, Fatih De Ramón, Cristina Petzer, Verena Del Principe, Maria Ilaria Navrátil, Milan Dargenio, Michelina Seval, Guldane Cengiz Samarkos, Michail Ráčil, Zdenĕk Pinczés László Imre (1990-) (általános orvos) Lahmer, Tobias Busca, Alessandro Méndez, Gustavo-Adolfo Vena, Antonio Biernat, Monika M. Merelli, Maria Calbacho, Maria Barać, Aleksandra Bavastro, Martina Limongelli, Alessandro Ilhan, Osman Wolf, Dominik Çolak, Gökçe Melis García-Sanz, Ramón Emarah, Ziad Mišković, Bojana Gräfe, Stefanie K. Mladenović, Miloš Aiello, Tommaso Francesco Núñez-Martín-Buitrago, Lucía Nordlander, Anna Arellano, Elena Zambrotta, Giovanni Paolo Maria Ammatuna, Emanuele Cabirta, Alba Sacchi, Maria Vittoria Rodrigues, Raquel Nunes Hersby, Ditte Stampe Hanáková, Michaela Rahimli, Laman Cordoba, Raul Cornely, Oliver Andreas Pagano, Livio
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001-es BibID:	BIBFORM113120
035-os BibID:	(cikkazonosító)101939 (scopus)85151507775
Első szerző:	Salmanton-García, Jon
Cím:	Nirmatrelvir/ritonavir in COVID-19 patients with haematological malignancies : a report from the EPICOVIDEHA registry / Salmanton-García Jon, Marchesi Francesco, Gomes da Silva Maria, Farina Francesca, Dávila-Valls Julio, Bilgin Yavuz M., Glenthj Andreas, Falces-Romero Iker, Van Doesum Jaap, Labrador Jorge, Buquicchio Caterina, El-Ashwah Shaimaa, Petzer Verena, Van Praet Jens, Schönlein Martin, Dargenio Michelina, Méndez Gustavo-Adolfo, Meers Stef, Itri Federico, Giordano Antonio, Pinczés László Imre, Espigado Ildefonso, Stojanoski Zlate, López-García Alberto, Prezioso Lucia, Jaksic Ozren, Vena Antonio, Fracchiolla Nicola S., González-López Tomás José, Colovic Natasa, Delia Mario, Weinbergerová Barbora, Marchetti Monia, Marques de Almeida Joyce, Finizio Olimpia, Besson Caroline, Biernat Monika M., Valkovic Toni, Lahmer Tobias, Cuccaro Annarosa, Ormazabal-Vélez Irati, Batinic Josip, Fernández Noemí, De Jonge Nick, Tascini Carlo, Anastasopoulou Amalia N., Duléry Rémy, Del Principe Maria Ilaria, Plantefeve Gaëtan, Papa Mario Virgilio, Nucci, Marcio; Jiménez, Moraima; Aujayeb, Avinash; Hernández-Rivas, José-Ángel; Merelli, Maria; Cattaneo, Chiara; Blennow, Ola; Nordlander, Anna; Cabirta, Alba; Varricchio, Gina; Sacchi, Maria Vittoria; Cordoba, Raul; Arellano, Elena; Gräfe, Stefanie K.; Wolf, Dominik, Emarah Ziad, Ammatuna Emanuele, Hersby Ditte Stampe, Martín-Pérez Sonia, Nunes Rodrigues, Raquel Rahimli, Laman, Pagano Livio, Cornely Oliver A., EPICOVIDEHA registry
Dátum:	2023
ISSN:	2589-5370
Megjegyzések:	Background Nirmatrelvir/ritonavir treatment decreases the hospitalisation rate in immunocompetent patients with COVID-19, but data on efficacy in patients with haematological malignancy are scarce. Here, we describe the outcome of nirmatrelvir/ritonavir treatment in a large cohort of the latter patients. Methods This is a retrospective cohort study from the multicentre EPICOVIDEHA registry (NCT04733729) on patients with haematological malignancy, who were diagnosed with COVID-19 between January and September 2022. eClinicalMedicine 2023;58: 101939 Published Online 6 April 2023 https://doi.org/10. 1016/j.eclinm.2023. 101939 Articles 2 www.thelancet.com Vol 58 April, 2023 Patients receiving nirmatrelvir/ritonavir were compared to those who did not. A logistic regression was run to determine factors associated with nirmatrelvir/ritonavir administration in our sample. Mortality between treatment groups was assessed with Kaplan?Meier survival plots after matching all the patients with a propensity score. Additionally, a Cox regression was modelled to detect factors associated with mortality in patients receiving nirmatrelvir/ritonavir. Findings A total of 1859 patients were analysed, 117 (6%) were treated with nirmatrelvir/ritonavir, 1742 (94%) were treated otherwise. Of 117 patients receiving nirmatrelvir/ritonavir, 80% had received ?1 anti-SARS-CoV-2 vaccine dose before COVID-19 onset, 13% of which received a 2nd vaccine booster. 5% were admitted to ICU. Nirmatrelvir/ritonavir treatment was associated with the presence of extrapulmonary symptoms at COVID-19 onset, for example anosmia, fever, rhinitis, or sinusitis (aOR 2.509, 95%CI 1.448?4.347) and 2nd vaccine booster (aOR 3.624, 95%CI 1.619?8.109). Chronic pulmonary disease (aOR 0.261, 95%CI 0.093?0.732) and obesity (aOR 0.105, 95%CI 0.014?0.776) were not associated with nirmatrelvir/ritonavir use. After propensity score matching, day-30 mortality rate in patients treated with nirmatrelvir/ritonavir was 2%, significantly lower than in patients with SARS-CoV-2 directed treatment other than nirmatrelvir/ritonavir (11%, p = 0.036). No factor was observed explaining the mortality difference in patients after nirmatrelvir/ritonavir administration. Interpretation Haematological malignancy patients were more likely to receive nirmatrelvir/ritonavir when reporting extrapulmonary symptoms or 2nd vaccine booster at COVID-19 onset, as opposed to chronic pulmonary disease and obesity. The mortality rate in patients treated with nirmatrelvir/ritonavir was lower than in patients with targeted drugs other than nirmatrelvir/ritonavir.
Tárgyszavak:	Orvostudományok Egészségtudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk Nirmatrelvir SARS-CoV-2 Haematology Malignancy COVID-19
Megjelenés:	eClinicalMedicine. - 58 (2023), p. 1-19. -
További szerzők:	Marchesi, Francesco Gomes Da Silva, Maria Farina, Francesca Dávila-Valls, Julio Bilgin, Yavuz M. Glenthj, Andreas Falces-Romero, Iker van Doesum, Jaap Labrador, Jorge Buquicchio, Caterina El-Ashwah, Shaimaa Petzer, Verena van Praet, Jens Schönlein, Martin Dargenio, Michelina Méndez, Gustavo-Adolfo Meers, Stef Itri, Federico Giordano, Antonio Pinczés László Imre (1990-) (általános orvos) Espigado, Ildefonso Stojanoski, Zlate López-García, Alberto Prezioso, Lucia Jaksic, Ozren Vena, Antonio Fracchiolla, Nicola S. González-López, Tomás José Colovic, Natasa Delia, Mario Weinbergerová, Barbora Marchetti, Monia Marques de Almeida, Joyce Finizio, Olimpia Besson, Caroline Biernat, Monika M. Valkovic, Toni Lahmer, Tobias Cuccaro, Annarosa Ormazabal-Vélez, Irati Batinić, Josip Fernández, Noemí de Jonge, Nick Tascini, Carlo Anastasopoulou, Amalia N. Duléry, Rémy Del Principe, Maria Ilaria Plantefeve, Gaëtan Papa, Mario Virgilio Nucci, Marcio Jiménez, Moraima Aujayeb, Avinash Hernández-Rivas, José-Ángel Merelli, Maria Cattaneo, Chiara Blennow, Ola Nordlander, Anna Cabirta, Alba Varricchio, Gina Sacchi, Maria Vittoria Cordoba, Raul Arellano, Elena Gräfe, Stefanie K. Wolf, Dominik Emarah, Ziad Ammatuna, Emanuele Hersby, Ditte Stampe Martín-Pérez, Sonia Nunes Rodrigues, Raquel Rahimli, Laman Pagano, Livio Cornely, Oliver Andreas EPICOVIDEHA registry
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001-es BibID:	BIBFORM104492
035-os BibID:	(cikkazonosító)e789 (WoS)000892089600005 (Scopus)85143836045
Első szerző:	Salmanton-García, Jon
Cím:	Improved Clinical Outcome of COVID-19 in Hematologic Malignancy Patients Receiving a Fourth Dose of Anti-SARS-CoV-2 Vaccine : an EPICOVIDEHA Report / Salmanton-García Jon, Marchesi Francesco, Glenthj Andreas, Bilgin Yavuz M., van Praet Jens, Dávila-Valls Julio, Martín-Pérez Sonia, Labrador Jorge, van Doesum Jaap, Falces-Romero Iker, Farina Francesca, Schönlein Martin, Chanut Mathilde, Petzer Verena, Espigado Ildefonso, Dargenio Michelina, Aujayeb Avinash, Sili Uluhan, Serrano Laura, Pinczés László Imre, de Jonge Nick, Soto-Silva Andrés, Buquicchio Caterina, Prezioso Lucia, Marchetti Monia, Meers Stef, Busca Alessandro, Corradini Paolo, Hoenigl Martin, Koehler Philipp, Rahimli Laman, Colak Gökce Melis, Arellano Elena, Wolf Dominik, Gräfe Stefanie, Ammatuna Emanuele, Berg Venemyr Caroline, Cornely Oliver A., Pagano Livio
Dátum:	2022
ISSN:	2572-9241
Tárgyszavak:	Orvostudományok Klinikai orvostudományok levél folyóiratcikk
Megjelenés:	HemaSphere. - 6 : 11 (2022), p. 1-4. -
További szerzők:	Marchesi, Francesco Glenthj, Andreas Bilgin, Yavuz M. van Praet, Jens Dávila-Valls, Julio Martín-Pérez, Sonia Labrador, Jorge van Doesum, Jaap Falces-Romero, Iker Farina, Francesca Schönlein, Martin Chanut, Mathilde Petzer, Verena Espigado, Ildefonso Dargenio, Michelina Aujayeb, Avinash Sili, Uluhan Serrano, Laura Pinczés László Imre (1990-) (általános orvos) de Jonge, Nick Soto-Silva, Andrés Buquicchio, Caterina Prezioso, Lucia Marchetti, Monia Meers, Stef Busca, Alessandro Corradini, Paolo Hoenigl, Martin Koehler, Philipp Rahimli, Laman Çolak, Gökçe Melis Arellano, Elena Wolf, Dominik Gräfe, Stefanie Ammatuna, Emanuele Berg Venemyr, Caroline Cornely, Oliver Andreas Pagano, Livio
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