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001-es BibID:BIBFORM095571
035-os BibID:(WoS)000627328400001 (Scopus)85102438552 (PubMed)33716672 (cikkazonosító)614947
Első szerző:Bayasgalan, Tsogbadrakh (Általános orvos)
Cím:Topographical Organization of M-Current on Dorsal and Median Raphe Serotonergic Neurons / Tsogbadrakh Bayasgalan, Andrea Csemer, Adrienn Kovacs, Krisztina Pocsai, Balazs Pal
Dátum:2021
ISSN:1662-5102
Megjegyzések:Dorsal and median raphe nuclei (DR and MR, respectively) are members of the reticular activating system and play important role in the regulation of the sleepwakefulness cycle, movement, and affective states. M-current is a voltage-gated potassium current under the control of neuromodulatory mechanisms setting neuronal excitability. Our goal was to determine the proportion of DR and MR serotonergic neurons possessing M-current and whether they are organized topographically. Electrophysiological parameters of raphe serotonergic neurons influenced by this current were also investigated. We performed slice electrophysiology on genetically identified serotonergic neurons. Neurons with M-current are located rostrally in the DR and dorsally in the MR. M-current determines firing rate, afterhyperpolarization amplitude, and adaptation index (AI) of these neurons, but does not affect input resistance, action potential width, and high threshold oscillations.These findings indicate that M-current has a strong impact on firing properties of certain serotonergic neuronal subpopulations and it might serve as an effective contributor to cholinergic and local serotonergic neuromodulatory actions.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:Frontiers in Cellular Neuroscience. - 15 (2021), p. 614947. -
További szerzők:Csemer Andrea (1994-) (molekuláris biológus) Kovács Adrienn (1989-) (molekuláris biológus) Pocsai Krisztina (1978-) (élettanász) Pál Balázs (1975-) (élettanász)
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2.

001-es BibID:BIBFORM095575
035-os BibID:(cikkazonosító)707789 (WoS)000683012200001 (Scopus)85112145519 (PubMed)34381336
Első szerző:Bayasgalan, Tsogbadrakh (Általános orvos)
Cím:Alteration of mesopontine cholinergic function by the lack of KCNQ4 subunit / Bayasgalan T., Stupniki S., Kovács A., Csemer A., Szentesi P., Pocsai K., Dionisio L., Spitzmaul G., Pál B.
Dátum:2021
ISSN:1662-5102
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:Frontiers in Cellular Neuroscience. - 15 (2021), p. 707789. -
További szerzők:Stupniki, S. Kovács Adrienn (1989-) (molekuláris biológus) Csemer Andrea (1994-) (molekuláris biológus) Szentesi Péter (1967-) (élettanász) Pocsai Krisztina (1978-) (élettanász) Dionisio, L. Spitzmaul, G. Pál Balázs (1975-) (élettanász)
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3.

001-es BibID:BIBFORM060223
Első szerző:Bordás Csilla
Cím:The M-current contributes to high threshold membrane potential oscillations in a cell type-specific way in the pedunculopontine nucleus of mice / Bordas Csilla, Kovacs Adrienn, Pal Balazs
Dátum:2015
ISSN:1662-5102
Megjegyzések:The pedunculopontine nucleus is known as a cholinergic nucleus of the reticular activating system, participating in regulation of sleep and wakefulness. Besides cholinergic neurons, it consists of GABAergic and glutamatergic neurons as well. According to classical and recent studies, more subgroups of neurons were defined. Groups based on the neurotransmitter released by a neuron are not homogenous, but can be further subdivided. The PPN neurons do not only provide cholinergic and non-cholinergic inputs to several subcortical brain areas but they are also targets of cholinergic and other different neuromodulatory actions. Although cholinergic neuromodulation has been already investigated in the nucleus, one of its characteristic targets, the M-type potassium current has not been described yet. Using slice electrophysiology, we provide evidence in the present work that cholinergic neurons possess M-current, whereas GABAergic neurons lack it. The M-current contributes to certain functional differences of cholinergic and GABAergic neurons, as spike frequency adaptation, action potential firing frequency or the amplitude difference of medium afterhyperpolarizations (AHPs). Furthermore, we showed that high threshold membrane potential oscillation with high power, around 20 Hz frequency is a functional property of almost all cholinergic cells, whereas GABAergic neurons have only low amplitude oscillations. Blockade of the M-current abolished the oscillatory activity at 20 Hz, and largely diminished it at other frequencies. Taken together, the M-current seems to be characteristic for PPN cholinergic neurons. It provides a possibility for modulating gamma band activity of these cells, thus contributing to neuromodulatory regulation of the reticular activating system.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
M-current
Neuromodulation
oscillatory activity
pedunculopontine nucleus
spike frequency adaptation
Megjelenés:Frontiers in Cellular Neuroscience. - 9 (2015), Article ID 121. -
További szerzők:Kovács Adrienn (1989-) (molekuláris biológus) Pál Balázs (1975-) (élettanász)
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Intézményi repozitóriumban (DEA) tárolt változat
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4.

001-es BibID:BIBFORM070540
Első szerző:Kovács Adrienn (molekuláris biológus)
Cím:Astrocyte-Dependent Slow Inward Currents (SICs) Participate in Neuromodulatory Mechanisms in the Pedunculopontine Nucleus (PPN) / Kovács Adrienn, Pál Balázs
Dátum:2017
Megjegyzések:Slow inward currents (SICs) are known as excitatory events of neurons caused by astrocytic glutamate release and consequential activation of neuronal extrasynaptic NMDA receptors. In the present article we investigate the role of these astrocyte-dependent excitatory events on a cholinergic nucleus of the reticular activating system (RAS), the pedunculopontine nucleus (PPN). It is well known about this and other elements of the RAS, that they do not only give rise to neuromodulatory innervation of several areas, but also targets neuromodulatory actions from other members of the RAS or factors providing the homeostatic drive for sleep. Using slice electrophysiology, optogenetics and morphological reconstruction, we revealed that SICs are present in a population of PPN neurons. The frequency of SICs recorded on PPN neurons was higher when the soma of the given neuron was close to an astrocytic soma. SICs do not appear simultaneously on neighboring neurons, thus it is unlikely that they synchronize neuronal activity in this structure. Occurrence of SICs is regulated by cannabinoid, muscarinic and serotonergic neuromodulatory mechanisms. In most cases, SICs occurred independently from tonic neuronal currents. SICs were affected by different neuromodulatory agents in a rather uniform way: if control SIC activity was low, the applied drugs increased it, but if SIC activity was increased in control, the same drugs lowered it. SICs of PPN neurons possibly represent a mechanism which elicits network-independent spikes on certain PPN neurons; forming an alternative, astrocyte-dependent pathway of neuromodulatory mechanisms.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
astrocyte
neuromodulation
optogenetics
pedunculopontine nucleus
slow inward current
Megjelenés:Frontiers in cellular neuroscience. - 11 : 16 (2017), p. 1-16. -
További szerzők:Pál Balázs (1975-) (élettanász)
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Intézményi repozitóriumban (DEA) tárolt változat
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