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001-es BibID:	BIBFORM117390
035-os BibID:	(Scopus)85152334418 (cikkazonosító)6203
Első szerző:	Dojcsák Dalma
Cím:	The Alterations of Serum N-glycome in Response to SARS-CoV-2 Vaccination / Dalma Dojcsák, Zsófia Kardos, Miklós Szabó, Csaba Oláh, Zsolt Körömi, Béla Viskolcz, Csaba Váradi
Dátum:	2023
ISSN:	1422-0067
Megjegyzések:	The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has caused a global concern since its outbreak in 2019, with one of the main solutions being vaccination. Altered glycosylation has been described in patients after SARS-CoV-2 infection, while the effect of vaccination on serum glycoproteins remained unexplored. In this study, total serum glycosylation was analyzed in patients after SARS-CoV-2 infection and/or mRNA vaccination in order to identify potential glycosylation-based alterations. Enzyme-linked immunosorbent assay was applied to identify post-COVID-19 and post-Vaccinated patients and rule out potential outliers. Serum samples were deglycosylated by PNGase F digestion, and the released glycans were fluorescently derivatized using procainamide labeling. Solid-phase extraction was used to purify the labeled glycans followed by the analysis of hydrophilic-interaction liquid chromatography with fluorescence and mass-spectrometric detection. Alterations of serum N-glycome in response to SARS-CoV-2 infection and mRNA vaccination were revealed by linear discriminant analysis.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk serum glycosylation COVID-19 vaccination liquid chromatography mass spectrometry
Megjelenés:	International Journal Of Molecular Sciences. - 24 : 7 (2023), p. 1-7. -
További szerzők:	Kardos Zsófia Szabó Miklós (1980-) (tüdőgyógyász) Oláh Csaba (1972-) (idegsebész) Körömi Zsolt Viskolcz Béla Váradi Csaba
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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