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001-es BibID:	BIBFORM063056
Első szerző:	Gonda Sándor (gyógyszerész)
Cím:	Efficient biotransformation of non-steroid anti-inflammatory drugs by endophytic and epiphytic fungi from dried leaves of a medicinal plant, Plantago lanceolata L. / Sandor Gonda, Attila Kiss-Szikszai, Zsolt Szucs, Borbala Balla, Gabor Vasas
Dátum:	2016
ISSN:	0964-8305
Megjegyzések:	In the current study, decomposition of diclofenac, diflunisal, ibuprofen, mefenamic acid and piroxicamwas tested using nine identified strains of endophytic and epiphytic fungi (from Ascomycota) adapted tonatural products resembling the pharmaceuticals. The strains were isolated from a medicinal plant,Plantago lanceolata leaves. Metabolites were tentatively identified by liquid chromatography e tandemmass spectrometry (LC-MS 3 ).Eighteen of the 45 combinations resulted in significant decrease of the concentration of the NSAIDs inmodel solutions. The most active strains were Aspergillus nidulans and Bipolaris tetramera, while Epi-coccum nigrum and Aspergillus niger showed somewhat less potency. Piroxicam and diclofenac were mostresistant to biotransformation, while ibuprofen and mefenamic acid were efficiently metabolized bymost strains. Ten metabolites could be tentatively identified, including hydroxy-metabolites of all testedNSAIDs, and a dihydroxy-metabolite of piroxicam. This biotransformation is likely to modify the toxicityand bioaccumulation potential of these pharmaceuticals.The results highlight the applicability of polyphenol-rich dried medicinal plant materials as anexcellent source of fungi with high biotransforming potential. The results also suggest more in-depthtesting of these fungi for biodegradation processes.
Tárgyszavak:	Természettudományok Biológiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban Biodegradation Biotransformation Non-steroid anti-inflammatory drugs Epiphytic fungi Phylloplane fungi Endophytes
Megjelenés:	International Biodeterioration & Biodegradation. - 108 (2016), p. 115-121. -
További szerzők:	Kiss-Szikszai Attila (1975-) (vegyész) Szűcs Zsolt (1990-) (gyógyszerész) Balla Borbála Vasas Gábor (1975-) (biológus-vegyész)
Pályázati támogatás:	TÁMOP-4.2.2.A-11/1/KONV-2012-0043 TÁMOP TAMOP-4.2.1./B-09/1/KONV-2010-0007 TÁMOP PD 112374 OTKA BAROSS REG_EA_09-1-2009-0028 Egyéb NTP-EF-O-P-15 Egyéb
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