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001-es BibID:BIBFORM109571
035-os BibID:(cikkazonosító)5147 (WoS)000955708300001 (Scopus)85151114076
Első szerző:Máthé Csaba (biológus)
Cím:"B" Regulatory Subunits of PP2A: Their Roles in Plant Development and Stress Reactions / Máthé Csaba, Freytag Csongor, Kelemen Adrienn, M-Hamvas Márta, Garda Tamás
Dátum:2023
ISSN:1422-0067
Megjegyzések:Protein phosphatase PP2A is an enzyme complex consisting of C (catalytic), A (scaffold) and B (regulatory) subunits. B subunits are a large family of proteins that regulate activity, substrate specificity and subcellular localization of the holoenzyme. Knowledge on the molecular functions of PP2A in plants is less than for protein kinases, but it is rapidly increasing. B subunits are responsible for the large diversity of PP2A functioning. This paper intends to give a survey on their multiple regulatory mechanisms. Firstly, we give a short description on our current knowledge in terms of "B"- mediated regulation of metabolic pathways. Next, we present their subcellular localizations, which extend from the nucleus to the cytosol and membrane compartments. The next sections show how B subunits regulate cellular processes from mitotic division to signal transduction pathways, including hormone signaling, and then the emerging evidence for their regulatory (mostly modulatory) roles in both abiotic and biotic stress responses in plants. Knowledge on these issues should be increased in the near future, since it contributes to a better understanding of how plant cells work, it may have agricultural applications, and it may have new insights into how vascular plants including crops face diverse environmental challenges.
Tárgyszavak:Természettudományok Biológiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
protein phosphatase PP2A
B subunit
subcellular localization
metabolism
development
signal transduction
abiotic stress
biotic stress
Megjelenés:International Journal Of Molecular Sciences. - 24 : 6 (2023), p. 1-13. -
További szerzők:Freytag Csongor (1993-) (biológus) Kelemen Adrienn (1995-) (Biológus) Mikóné Hamvas Márta (1963-) (biológus) Garda Tamás (1990-) (biológus)
Pályázati támogatás:OTKA-120638
OTKA
ÚNKP-22-4-I-DE-11
Egyéb
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2.

001-es BibID:BIBFORM090863
035-os BibID:(cikkazonosító)975 (scopus)85100049287 (wos)000611313400001
Első szerző:Máthé Csaba (biológus)
Cím:The Protein Phosphatase PP2A Plays Multiple Roles in Plant Development by Regulation of Vesicle Traffic?Facts and Questions / Csaba Máthé, Márta M-Hamvas, Csongor Freytag, Tamás Garda
Dátum:2021
ISSN:1661-6596 1422-0067
Megjegyzések:The protein phosphatase PP2A is essential for the control of integrated eukaryotic cell functioning. Several cellular and developmental events, e.g., plant growth regulator (PGR) mediated signaling pathways are regulated by reversible phosphorylation of vesicle traffic proteins. Reviewing present knowledge on the relevant role of PP2A is timely. We discuss three aspects: (1) PP2A regulates microtubule-mediated vesicle delivery during cell plate assembly. PP2A dephosphorylates members of the microtubule associated protein family MAP65, promoting their binding to microtubules. Regulation of phosphatase activity leads to changes in microtubule organization, which affects vesicle traffic towards cell plate and vesicle fusion to build the new cell wall between dividing cells. (2) PP2A-mediated inhibition of target of rapamycin complex (TORC) dependent signaling pathways contributes to autophagy and this has possible connections to the brassinosteroid signaling pathway. (3) Transcytosis of vesicles transporting PIN auxin efflux carriers. PP2A regulates vesicle localization and recycling of PINs related to GNOM (a GTP?GDP exchange factor) mediated pathways. The proper intracellular traffic of PINs is essential for auxin distribution in the plant body, thus in whole plant development. Overall, PP2A has essential roles in membrane interactions of plant cell and it is crucial for plant development and stress responses.
Tárgyszavak:Természettudományok Biológiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
protein phosphatase PP2A
vesicle traffic
phragmoplast
cell plate
autophagy
PIN auxin efflux carriers
transcytosis
Megjelenés:International Journal Of Molecular Sciences. - 22 : 2 (2021), p. 1-18. -
További szerzők:Mikóné Hamvas Márta (1963-) (biológus) Freytag Csongor (1993-) (biológus) Garda Tamás (1990-) (biológus)
Pályázati támogatás:Egyéb
OTKA
ÚNKP-20-3-II-DE-412
Egyéb
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3.

001-es BibID:BIBFORM079357
035-os BibID:(cikkazonosító)3028 (wos)000473756000178 (scopus)85068751603
Első szerző:Máthé Csaba (biológus)
Cím:The role of serine-threonine protein phosphatase PP2A in plant oxidative stress signaling : facts and hypotheses / Csaba Máthé, Tamás Garda, Csongor Freytag, Márta M-Hamvas
Dátum:2019
ISSN:1661-6596 1422-0067
Megjegyzések:Abiotic and biotic factors induce oxidative stress involving the production and scavenging of reactive oxygen species (ROS). This review is a survey of well-known and possible roles of serine-threonine protein phosphatases in plant oxidative stress signaling, with special emphasis on PP2A . ROS mediated signaling involves three interrelated pathways: (i) perception of extracellular ROS triggers signal transduction pathways, leading to DNA damage and/or the production of antioxidants; (ii) external signals induce intracellular ROS generation that triggers the relevant signaling pathways and (iii) external signals mediate protein phosphorylation dependent signaling pathway(s), leading to the expression of ROS producing enzymes like NADPH oxidases. All pathways involve inactivation of serine-threonine protein phosphatases. The metal dependent phosphatase PP2C has a negative regulatory function during ABA mediated ROS signaling. PP2A is the most abundant protein phosphatase in eukaryotic cells. Inhibitors of PP2A exert a ROS inducing activity as well and we suggest that there is a direct relationship between these two effects of drugs. We present current findings and hypotheses regarding PP2A-ROS signaling connections related to all three ROS signaling pathways and anticipate future research directions for this field. These mechanisms have implications in the understanding of stress tolerance of vascular plants, having applications regarding crop improvement.
Tárgyszavak:Természettudományok Biológiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:International Journal of Molecular Sciences. - 20 : 12 (2019), p. 1-18. -
További szerzők:Garda Tamás (1990-) (biológus) Freytag Csongor (1993-) (biológus) Mikóné Hamvas Márta (1963-) (biológus)
Pályázati támogatás:NKFIH K120638
OTKA
Internet cím:Szerző által megadott URL
Intézményi repozitóriumban (DEA) tárolt változat
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