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001-es BibID:	BIBFORM112655
035-os BibID:	(cikkazonosító)1521 (WoS)001016958800001 (Scopus)85163850116
Első szerző:	Muzsai Szabolcs
Cím:	Cell-Free Supernatant Derived from a Lactobacillus casei BL23 Culture Modifies the Antiviral and Immunomodulatory Capacity of Mesenchymal Stromal Cells / Szabolcs Muzsai, Ore-Matan Maryanovsky, Roland Ander, Gábor Koncz, Anett Mázló, Attila Bácsi, Márta Tóth
Dátum:	2023
ISSN:	2227-9059
Megjegyzések:	Immune responses are highly complex and intricately regulated processes involving immune and non-immune cells in close direct and indirect contact with each other. These cells are highly sensitive to environmental signals, including factors derived from microbiota. Here, we demonstrate that the human microbiota member Lactobacillus casei (L. casei)-derived cell-free supernatant (CFS) enhances the sensitivity of mesenchymal-stromal-cell-like (MSCI) cells to viral stimuli and induces the development of dendritic cells (DCs) with anti-inflammatory and antiviral properties via pretreated MSCl cells. Our results showed that the production of INF & beta; and CXCL10 by MSCl cells upon viral stimulation was dependent on the presence of L. casei-derived extracellular vesicles in CFS during pretreatment. Moreover, L. casei CFS and/or poly (I:C)-conditioned MSCI cells altered the differentiation process of freshly isolated monocytes, as well as the developing DCs' phenotype and functional activities, such as cytokine and chemokine secretion. Taken together, L. casei CFS contains factors which contribute to the pronounced antiviral response of MSCI cells, avoiding the development of inflammation via the induction of differentiation of anti-inflammatory DCs that retain their antiviral properties.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk Lactobacillus mezenhimális sztrómasejtek dendritikus sejt immunmoduláció extracelluláris vezikulák
Megjelenés:	Biomedicines. - 11 : 6 (2023), p. 1-19. -
További szerzők:	Maryanovsky, Ore-Matan Ander Roland (1997-) (orvosi kutatólaboratóriumi analitikus) Koncz Gábor (1984-) (biológus) Türk-Mázló Anett (1989-) (molekuláris biológus) Bácsi Attila (1967-) (immunológus) Tóth Márta (1986-) (biológus)
Pályázati támogatás:	TÁMOP-4.2.2.A-11/1/KONV-2012 0023 TÁMOP K125337 OTKA PD142930 OTKA GINOP-2.3.2-15-2016-00050 GINOP
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