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001-es BibID:BIBFORM098839
035-os BibID:(scopus)85109407363 (wos)000676766900001
Első szerző:Tóth Gergő Dániel
Cím:Nanofibrous Formulation of Cyclodextrin Stabilized Lipases for Efficient Pancreatin Replacement Therapies / Tóth Gergő Dániel, Kazsoki Adrienn, Gyarmati Benjámin, Szilágyi András, Vasvári Gábor, Katona Gábor, Szente Lajos, Zelkó Romána, Poppe László, Balogh-Weiser Diána, Balogh György T.
Dátum:2021
ISSN:1999-4923
Megjegyzések:Enzyme replacement therapies (ERT) have been of great help over the past 30 years in the treatment of various lysosomal storage disorders, including chronic pancreatitis and its common complication, exocrine pancreatic insufficiency. Research shows that difficulties in designing such drugs can be overcome by using appropriate additives and various enzyme immobilization techniques. Cyclodextrins (CDs) can be considered as a promising additive for enzyme replacement therapies, as they are known to enhance the activity of enzymes in a complex process due to their specific binding. In this study, we investigated the formulation of lipases (from Aspergillus oryzae and Burkholderia cepacia) paired with different cyclodextrins in poly(vinyl alcohol) (PVA) nanofibers by electrospinning technique. We examined the effect of the presence of cyclodextrins and nanoformulation on the lipase activity. The rheological and morphological characterizations of precursors and nanofibers were also performed using a viscometer as well as electron and Raman microscope. We found that by selecting the appropriate CD:lipase ratio, the activity of the investigated enzyme could be multiplied, and cyclodextrins can support the homogeneous dispersion of lipases inside the solid formula. In addition, the entrapment of lipases in PVA nanofibers led to a significant increase in activity compared to the preformulated precursor. In this way, the nanofibrous formulation of lipases combining CDs as additives can provide an efficient and sustainable possibility for designing novel solid medicines in ERT.
Tárgyszavak:Orvostudományok Gyógyszerészeti tudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
pancreatic enzyme replacement therapy (PERT)
lipase
cyclodextrin
electrospinning
nanofibrous enzyme formulation
Megjelenés:Pharmaceutics. - 13 : 7 (2021), p. 1-18. -
További szerzők:Kazsoki Adrienn Gyarmati Benjámin Szilágyi András Vasvári Gábor (1990-) (gyógyszerész, gyógyszertechnológus) Katona Gábor Szente Lajos (1951-) (vegyész) Zelkó Romána Poppe László Balogh-Weiser Diána Balogh György Tibor
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