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001-es BibID:BIBFORM077568
Első szerző:Szűcs Miklós (urológus, andrológus)
Cím:Hyaluronan bound mature sperm count (HB-MaSC) is a more informative indicator of fertility than conventional sperm parameters : correlations with Body Mass Index (BMI) / Miklos Szucs, Peter Osvath, Attila Jakab, Daniel Varga, Balazs Varga, Bela Juhasz
Dátum:2019
ISSN:1642-431X
Megjegyzések:The relationship between overweight and male fertility is well studied, still the correlation of obesity and de- creased sperm quality is a subject to debate. The widely used conventional spermatological examinations alone seem to be inadequate to assess fertilization potential. Hyaluronan Binding Assay (HBA?) is one of the available validated tests that allows the functional examination of sperm. Data of 72 male patients (mean age 33.9 (24?43) years) from infertile couples were analysed. Body Mass Index (BMI) determination, conventional semen analysis and HBA were performed. Additionally, a relatively new Hyaluronan Bound Matured Sperm Count (HB-MaSC) -index, first introduced by the authors in 2015, was calculated. This index reflects fertilization potential of sperm more precisely. With the increase of BMI, sperm count decreased significantly until about 25kg/m2, above 25 kg/m2 no further decrease was observed, although sperm count remained permanently low. Greater body weight (in the 70?90 kg range) was observed to have a significant negative effect only on the progressive sperm motility. In addition to sperm concentration and motility, sperm fertilization potential is also negatively affected by obesity, but is irrespective of body weight, as evaluated using BMI + HB-MaSC linear regression analyses adjusted for age and weight. This correlation between male BMI and sperm fertilization potential ? as opposed to the conventional correlations with sperm concentration or motility ? appears to provide more helpful in- formation in the identification of real capability for fertilization.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
sperm quality
obesity
sperm function
hyaluronan binding
Megjelenés:Reproductive Biology. - 19 : 1 (2019), p. 38-44. -
További szerzők:Osváth Péter Jakab Attila (1964-) (szülész-nőgyógyász, endokrinológus) Varga Dániel (1990-) (általános orvos) Varga Balázs (1984-) (kísérletes farmakológus) Juhász Béla (1978-) (kísérletes farmakológus)
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