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001-es BibID:BIBFORM060508
Első szerző:Albert Réka
Cím:Triamcinolone regulated apopto-phagocytic gene expression patterns in the clearance of dying retinal pigment epithelial cells. A key role of Mertk in the enhanced phagocytosis / Réka Albert, Endre Kristóf, Gábor Zahuczky, Mária Szatmári-Tóth, Zoltán Veréb, Brigitta Oláh, Morten C. Moe, Andrea Facskó, László Fésüs, Goran Petrovski
Dátum:2015
ISSN:0304-4165
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:Biochimica et Biophysica Acta (BBA). General Subjects. - 1850 : 2 (2015), p. 435-446. -
További szerzők:Kristóf Endre (1987-) (általános orvos) Zahuczky Gábor (1975-) (molekuláris biológus, biokémikus, vegyész) Szatmári-Tóth Mária (1987-) (molekuláris biológus) Veréb Zoltán (1980-) (immunológus, mikrobiológus, molekuláris biológus) Oláh Brigitta Moe, Morten C. Facskó Andrea (1953-) (szemész) Fésüs László (1947-) (orvos biokémikus) Petrovski, Goran (1975-) (orvos)
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2.

001-es BibID:BIBFORM079715
035-os BibID:(WOS)000470970000010 (PMID)31185026 (Scopus)85067077554 (cikkazonosító)e0217548
Első szerző:Josifovska, Natasha (Biológus)
Cím:Clinical and molecular markers in retinal detachment : From hyperreflective points to stem cells and inflammation / Natasha Josifovska, Xhevat Lumi, Mária Szatmari-Tóth, Endre Kristóf, Greg Russell, Richárd Nagymihály, Natalia Anisimova, Boris Malyugin, Miriam Kolko, Domagoj Ivastinović, Goran Petrovski
Dátum:2019
ISSN:1932-6203
Megjegyzések:PURPOSE: Retinal detachment (RD) is one of the most frequently diagnosed ophthalmologic conditions requiring prompt surgical intervention. Combination of proper surgical technique and new diagnostic markers, both clinical and molecular, can help improve the diagnosis and prognosis of RD treatment. METHODS: 12 patients with rhegmatogenous RD (rRD) were included into the study after obtaining patient consent and Regional Ethical Approval (average age: 58.1 ? 17.4 years). OCT was performed before and after 23G vitrectomy for RD. Pure subretinal fluid (SRF) was collected during surgery and analyzed by protein array profiling on a panel of 105 inflammatory cytokines (Human XL Cytokine Array), while the effect of SRF upon human macrophages-driven phagocytosis of apoptotic retinal pigment epithelial (RPE) cells ex vivo was quantified by flow cytometry. Immunohistochemistry (IHC) of retinectomized tissue due to PVR caused by RD was performed to determine presence of markers for microglial cells (CD34), macrophages and activated microglia (CD68), regulator of the immune response to infection (NFkB), progenitor and stem cell marker (Sox2), pluripotency marker (Oct4) and intermediate filament markers (GFAP and Nestin). RESULTS: OCT of fresh RD patients contained pre-operatively hyper reflective points (HRPs) at the detached neuroretina border and proximal to the RPE layer-their size and number decreased following successful reattachment surgery. IHC of the retinectomized tissue from detached retina due to severe PVR showed presence of cell conglomerates at the detached neuroretina border which were positive for CD68, NFkB, Sox2 and GFAP, less positive for CD47 and Nestin and negative for Oct4 and CD34. The SRF contained at least 37 cytokines with higher, and 4 cytokine with lower concentration compared to that in vitreous from non-RD pathology; when used as conditional medium to human macrophages ex vivo, the SRF doubled their capacity for engulfing dying RPEs. CONCLUSIONS: Fresh RD can be hallmarked by presence of HRPs at the detached neuroretina border on OCT; the HRPs decrease in size and number after successful reattachment surgery, and likely resemble the macrophage conglomerates seen by IHC. The neuroretina in RD contains progenitor/stem-like cells and signs of inflammatory reaction, while the SRF contains inflammatory cytokines and other factors which increase the ability of professional phagocytes to engulf dying RPE, or for that matter, other dying cells in the retina.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:Plos One. - 14 : 6 (2019), p. e0217548. -
További szerzők:Lumi, Xhevat Szatmári-Tóth Mária (1987-) (molekuláris biológus) Kristóf Endre (1987-) (általános orvos) Russell, Greg Nagymihály Richárd (1989-) (klinikai laboratóriumi kutató) Anisimova, Natalia Malyugin, Boris Kolko, Miriam Ivastinović, Domagoj Petrovski, Goran (1975-) (orvos)
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3.

001-es BibID:BIBFORM064980
Első szerző:Szabó Dóra Júlia (Ph.D hallgató)
Cím:Cell death, clearance and inflammation : molecular crossroads and gene polymorphisms in the pathogenesis of age-related macular degeneration / Szabó Dóra Júlia, Szatmári-Tóth Mária, Doró Zoltán, Nagymihály Richárd, Natasha Josifovska, Facskó Andrea, Goran Petrovski
Dátum:2014
Megjegyzések:Age-related macular degeneration (AMD) is the leading cause of irreversible loss of vision anddecrease in quality of life in the elderly. A large number of molecular crossroads between cell death,phagocytosis and inflammation have been described in AMD. The different forms of cell death - apoptosis,anoikis, autophagy, necrosis, necroptosis and pyroptosis, have all been studied under different circumstances inthe retina and in AMD pathology. Much less is known about the clearance of these dying cells by nonprofessional(living retinal pigment epithelial (RPE) cells) and professional (macrophages and dendritic cells)phagocytes. The molecular synapse between the dying cells and the phagocytes is far from complete inrelevance to AMD. Gene polymorphism of the phagocytic bridging molecules and those involved ininflammation and angiogenesis further complicate the lock-and-key theory in the clearance of dying cells inAMD. The present review gives an overview of the different risk factors, cell death types and clearancemechanisms in the retina, and their implications to inflammation and angiogenesis in AMD. A correlation of thegenetic factors affecting AMD to those of other neurodegenerative diseases (Alzheimer's, Huntington andParkinson's) is also attempted here.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
sejthalál, apoptózis, autofágia, fagocitózis, gyulladás, gén polimorfizmus, neurodegeneratív betegségek, időskori makula degeneráció
Megjelenés:Journal of Biochemical and Pharmacological Research. - 2 : 3 (2014), p. 132-143. -
További szerzők:Szatmári-Tóth Mária (1987-) (molekuláris biológus) Doró Zoltán (1981-) (biotechnológus) Nagymihály Richárd (1989-) (klinikai laboratóriumi kutató) Josifovska, Natasha (1987-) (Biológus) Facskó Andrea (1953-) (szemész) Petrovski, Goran (1975-) (orvos)
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4.

001-es BibID:BIBFORM078244
035-os BibID:(PMID)30791639 (cikkazonosító)E926 (scopus)85061990156 (wos)000460805400134
Első szerző:Szatmári-Tóth Mária (molekuláris biológus)
Cím:Human Embryonic Stem Cell-Derived Retinal Pigment Epithelium-Role in Dead Cell Clearance and Inflammation / Mária Szatmári-Tóth, Tanja Ilmarinen, Alexandra Mikhailova, Heli Skottman, Anu Kauppinen, Kai Kaarniranta, Endre Kristóf, Lyubomyr Lytvynchuk, Zoltán Veréb, László Fésüs, Goran Petrovski
Dátum:2019
ISSN:1661-6596 1422-0067
Megjegyzések:Inefficient removal of dying retinal pigment epithelial (RPE) cells by professional phagocytes can result in debris formation and development of age-related macular degeneration (AMD). Chronic oxidative stress and inflammation play an important role in AMD pathogenesis. Only a few well-established in vitro phagocytosis assay models exist. We propose human embryonic stem cell-derived-RPE cells as a new model for studying RPE cell removal by professional phagocytes. The characteristics of human embryonic stem cells-derived RPE (hESC-RPE) are similar to native RPEs based on their gene and protein expression profile, integrity, and barrier properties or regarding drug transport. However, no data exist about RPE death modalities and how efficiently dying hESC-RPEs are taken upby macrophages, and whether this process triggers an inflammatory responses. This study demonstrates hESC-RPEs can be induced to undergo anoikis or autophagy-associated cell death due to extracellular matrix detachment or serum deprivation and hydrogen-peroxide co-treatment, respectively, similar to primary human RPEs. Dying hESC-RPEs are efficiently engulfed by macrophages which results in high amounts of IL-6 and IL-8 cytokine release. These findings suggest that the clearance of anoikic and autophagy-associated dying hESC-RPEs can be used as a new model for investigating AMD pathogenesis or for testing the in vivo potential of these cells in stem cell therapy.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
age-related macular degeneration
anoikis
autophagy
hESC-RPE
inflammation
macrophages
phagocytosis
triamcinolone
Megjelenés:International Journal of Molecular Sciences. - 20 : 4 (2019), p. 1-20. -
További szerzők:Ilmarinen, Tanja Mikhailova, Alexandra Skottman, Heli Kauppinen, Anu (1977-) (sejtbiológus) Kaarniranta, Kai (1972-) (szemész szakorvos) Kristóf Endre (1987-) (általános orvos) Lytvynchuk, Lyubomyr Veréb Zoltán (1980-) (immunológus, mikrobiológus, molekuláris biológus) Fésüs László (1947-) (orvos biokémikus) Petrovski, Goran (1975-) (orvos)
Pályázati támogatás:GINOP-2.3.2-15-2016-00006
GINOP
ÚNKP-18-4
ÚNKP
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