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001-es BibID:	BIBFORM103564
035-os BibID:	(WoS)000863090700018 (Scopus)85137072456 (Cikkazonosító)158305
Első szerző:	Pál László (népegészségügyi szakember, egészségfejlesztő)
Cím:	Health and economic gain attributable to the introduction of the World Health Organization's drinking water standard on arsenic level in Hungary : a nationwide retrospective study on cancer occurrence and ischemic heart disease mortality / Pál László, Jenei Tibor, McKee Martin, Kovács Nóra, Vargha Márta, Bufa-Dőrr Zsuzsanna, Muhollari Teuta, Bujdosó Marozsán Orsolya, Sándor János, Szűcs Sándor
Dátum:	2022
ISSN:	0048-9697
Megjegyzések:	The World Health Organization (WHO) estimates that 140 million individuals are at risk from consumption of drinking water containing arsenic at concentrations above the WHO guideline value of 10 ?g/l. Arsenic mitigation is considered to be the most effective way to prevent arsenic related diseases. After joining the European Union, Hungary implemented a Drinking Water Quality Improvement Programme (DWQIP) to reduce levels of arsenic in drinking water below the WHO guideline value. But what impact did this have on health? We estimated the change in lifetime excess skin, lung, and bladder cancer risks and mortality from ischaemic heart disease (IHD) associated with chronic arsenic intake among those exposed before (2004?2007) and after (2014?2017) the implementation of DWQIP. A populationbased risk assessment approach was used to assess lifetime excess cancer risk applying two scenarios for lung and bladder cancers. The economic benefits of the DWQIP were estimated by the combination of cost of illness and value per statistical life methods. Compared to the period before the DWQIP, its implementation was associated with a significant reduction in arsenic in drinking water [median: 3.0 ?g/l interquartile range (IQR): 1.5?12.0 ?g/l to median: 2.15 ?g/l IQR: 1.0?5.79 ?g/l]. The two scenarios were estimated to be associated with 225.2 and 35.9 fewer cancer cases each year. The number of annually prevented IHD deaths was estimated to be 88.9. It was estimated that the benefits of the DWQIP will outweigh its costs. We conclude that reducing arsenic levels in drinking water to 10.0 ?g/l resulted in significant health and economic benefits. Our study goes beyond the existing research, offering both new insights into the impact of arsenic mitigation and providing a methodological template for similar studies in the many parts of the world that have yet to reduce arsenic exposure.
Tárgyszavak:	Orvostudományok Egészségtudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk Arsenic exposure WHO drinking water standard Arsenic mitigation Cancer risk assessment Mortality from ischemic heart disease Public health and economic benefits
Megjelenés:	Science Of The Total Environment. - 851 (2022), p. 1-11. -
További szerzők:	Jenei Tibor (1963-) (programtervező informatikus) McKee, Martin Kovács Nóra (1989-) (népegészségügyi szakember) Vargha Márta Bufa-Dőrr Zsuzsanna Muhollari, Teuta Bujdosó Orsolya (1992-) (népegészségügyi szakember) Sándor János (1966-) (orvos-epidemiológus) Szűcs Sándor (1958-) (biokémikus, vegyész)
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM086924
035-os BibID:	(cikkazonosító)104723
Első szerző:	Pál László (népegészségügyi szakember, egészségfejlesztő)
Cím:	Heavy metal contamination in recorded and unrecorded spirits. Should we worry? / Pál László, Teuta Muhollari, Bujdosó Orsolya, Baranyai Edina, Nagy Attila, Árnyas Ervin, Ádány Róza, Sándor János, Martin McKee, Szűcs Sándor
Dátum:	2020
ISSN:	0273-2300
Megjegyzések:	Heavy metals can be released into all alcoholic beverages during production and storage. However, there is at least a theoretical risk that they could be present in higher, and potentially toxic, concentrations in those produced in the household and small-scale stills common in Central and Eastern Europe, which lack quality control and whose products are unrecorded by authorities. Yet, so far, few studies comparing concentrations of heavy metals in recorded and unrecorded spirits have been published. In this study we ask whether there is any difference between heavy metal concentrations in recorded and unrecorded spirits and, thus, the related health risk. The levels of heavy metals were determined in recorded (n ? 97) and unrecorded (n ? 100) spirits using inductively coupled plasma optical emission spectrometric analysis and applied to population-based risk assessments, considering average, regular and chronic heavy drinkers. Concentrations of Cu, Zn, and Sn were significantly higher in unrecorded spirits than those in their recorded counterparts and recorded spirits contained significantly higher levels of Fe, Mn, and Ni than unrecorded spirits. Combined exposure to heavy metals posed a potential health risk in chronic heavy drinkers consuming recorded spirits. However, when compared to the health risk arising from drinking large volumes of ethanol, the risk is negligible. Consequently, there are no grounds to worry about the adverse effects of heavy metals from spirits.
Tárgyszavak:	Orvostudományok Egészségtudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk Alcohol consumption Recorded and unrecorded spirits Heavy metals Target hazard quotient Hazard index
Megjelenés:	Regulatory Toxicology And Pharmacology. - 116 (2020), p. 1-10. -
További szerzők:	Muhollari, Teuta Bujdosó Orsolya (1992-) (népegészségügyi szakember) Baranyai Edina (1987-) (környezetkutató) Nagy Attila Csaba (1981-) (megelőző orvostan és népegészségtan szakorvos, epidemiológus) Árnyas Ervin (1974-) (biológus-ökológus) Ádány Róza (1952-) (megelőző orvostan és népegészségtan szakorvos) Sándor János (1966-) (orvos-epidemiológus) McKee, Martin Szűcs Sándor (1958-) (biokémikus, vegyész)
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