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001-es BibID:	BIBFORM092505
035-os BibID:	(cikkazonosító)10761 (WOS)000546550700075 (Scopus)85087302594
Első szerző:	Jakab Zsuzsanna (gyermekgyógyász)
Cím:	Late mortality in survivors of childhood cancer in Hungary / Jakab Zsuzsanna, Garami Miklos, Bartyik Katalin, Csoka Monika, Erdelyi Daniel Janos, Hauser Peter, Juhasz Attila, Kelemen Agnes, Krivan Gergely, Masat Peter, Müller Judit, Nagy Csilla, Peter György, Renyi Imre, Szegedi Istvan, Vojcek Agnes, Zombori Marianna, Bardi Edit, Kovacs Gabor
Dátum:	2020
ISSN:	2045-2322
Megjegyzések:	The Hungarian Pediatric Oncology Network provides centralized treatment and population-based registration for cases of childhood cancer since 1973. We collected and analized data on late mortality, secondary malignancies and cardiac diseases in survivors (>?5 years) of childhood cancer to evaluate long-term risks. We extracted all solid tumour cases (3,650 followed up for 5?39.3 years, diagnosis: 1973?2008) from the database of the Hungarian Childhood Cancer Registry and checked against the Population Registry. Among the 301 patients who died after 5 years (8.2%) the most common causes of death were progression of primary cancer (52.5%), secondary malignancies (16%) and cardiovascular diseases (8%). Late mortality rates (SMR, total: 35,006 pyrs) showed highly elevated risk of death (SMR: 10.7 95% CI 9?12.4) for the second 5 years of follow up and moderately elevated risk for 10-year survivors (SMR: 3.5 95% CI 3?4.1). Marked differences were detected in the pattern of causes of death between diagnostic groups of primary cancer; with highest risks beyond 10 years for CNS tumours, Hodgkin disease, osteosarcoma and advanced stage neuroblastoma. The longstanding mortality risk for 5-year survivors underlines the need for tailored long-term follow-up and monitoring of late consequences according to the context of different primary diseases of childhood cancer.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk late mortality
Megjelenés:	Scientific Reports. - 10 (2020), p. 1-9. -
További szerzők:	Garami Miklós Bartyik Katalin (haematológus) Csóka Mónika Erdélyi Dániel Hauser, Peter Juhász Attila (1970-) (epidemiológus) Kelemen Ágnes Kriván Gergely Masát Péter (gyermekorvos Szombathely) Müller Judit Nagy Csilla (1970-) (epidemiológus, népegészségügyi szakember) Péter György Rényi Imre (gyermekhaematológus Budapest) Szegedi István (1969-) (hematológus, onkológus, nefrológus) Vojcek Ágnes Zombori Marianna Bárdi Edit (1971-) (csecsemő- és gyermekgyógyász) Kovács Gábor (gyermekhaematológus Budapest)
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM092503
Első szerző:	Jakab Zsuzsanna (gyermekgyógyász)
Cím:	Trends and territorial inequalities of incidence and survival of childhood leukaemia and their relations to socioeconomic status in Hungary, 1971-2015 / Jakab Zsuzsanna, Juhasz Attila, Nagy Csilla, Schuler Dezso, Garami Miklos, Hungarian Paediatric Haemato-Oncology Network
Dátum:	2017
ISSN:	0959-8278
Megjegyzések:	The Hungarian Childhood Cancer Registry, a population-based national registry of the Hungarian Paediatric Haemato-Oncology Network founded in 1971, monitors the incidence and mortality of childhood cancer. Our aims were to carry out a longitudinal study to investigate the trends and spatial inequalities of incidence and survival of leukaemia, and the association between survival and deprivation in Hungary. All cases of childhood leukaemia and myelodysplasia were analysed (3157 cases, 1971?2015, age: 0?14 years). Time trends and the annual percentage change in direct standardized incidence and mortality were assessed. Survival and association with deprivation were assessed using the Kaplan?Meier method and Cox regression. Incidence rates of leukaemia (23.5?56.0/million) increased with an average annual percent change (AAPC) of 1%, determined by an increase in the incidence of acute lymphoblastic leukaemia (14.6?39.2/million, AAPC: 1.25%). Kaplan?Meier analysis showed a significant improvement in overall survival over the study period. Starting from 25% of cases surviving 5 years in the 70s; the overall 5-year survival reached 80% by 2010. Survival differences were observed with sex, leukaemia type and age at diagnosis. A reverse association was found in the survival probability of leukaemia by degree of deprivation. The Cox proportional hazards model verified a significant reverse association with deprivation [hazard ratio=1.08 (1.04?1.12)]. This is the first nationwide study to confirm the prognostic role of deprivation on the basis of a large cohort of patients with childhood leukaemia during a 45-year period. To maintain further improvement in treatment results, it is important to detect inequalities. Our results showed that deprivation may also be important in the survival of leukaemia.
Tárgyszavak:	Orvostudományok Egészségtudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk leukémia 1
Megjelenés:	European Journal Of Cancer Prevention. - 26 (2017), p. S183-S190. -
További szerzők:	Juhász Attila (1970-) (epidemiológus) Nagy Csilla (1970-) (epidemiológus, népegészségügyi szakember) Schuler Dezső Garami Miklós Hungarian Paediatric Haemato-Oncology Network
Internet cím:	DOI Intézményi repozitóriumban (DEA) tárolt változat
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