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001-es BibID:	BIBFORM083679
Első szerző:	Bencze János (orvos)
Cím:	Dementia with Lewy bodies - a clinicopathological update / János Bencze, Woosung Seo, Abdul Hye, Dag Aarsland, Tibor Hortobágyi
Dátum:	2020
Megjegyzések:	Dementia is one of the major burdens of our aging society. According to certain predictions, the number of patients will double every 20 years. Although Alzheimer's disease (AD), as the most frequent neurodegenera-tive dementia, has been extensively analysed, less is known about dementia with Lewy bodies (DLB). Neuropa-thological hallmarks of DLB are the deposition of intracellular Lewy bodies (LB) and Lewy neurites (LN). DLB belongs to the ?-synucleinopathies, as the major component of these inclusions is pathologically aggregated ?-synuclein. Depending on the localizationof LBs and LNs in the central nervous system cognitive and motor symptoms can occur. In our work, we will systematically review the possible etiology and epidemiology, patho-logical (both macroscopic and microscopic) features, structural and functional imaging findings, with a special emphasis on the clinico-pathological correlations. Finally, we summarize the latest clinical symptoms-based diagnostic criteria and the novel therapeutic approaches. Since DLB is frequently accompanied with AD pathol-ogy, highlighting possible differential diagnostic approaches is an integral part of our paper. Although our pre-sent knowledge is insufficient, the rapid development of diagnostic and research methodsprovide hope for better diagnosis and more efficient treatment, contributing to a better quality of life.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk
Megjelenés:	Free Neuropathology. - 1 (2020), p. 1-12. -
További szerzők:	Seo, Woosung Hye, Abdul Aarsland, Dag Hortobágyi Tibor (1965-) (patológus)
Pályázati támogatás:	EFOP-3.6.3-VEKOP-16-2017-00009 EFOP GINOP-2.3.2-15-2016-00043 GINOP NAP (2017-1.2.1-NKP-2017-00002) Egyéb ÚNKP-19-3 Egyéb NKFIH SNN 132999 Egyéb
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001-es BibID:	BIBFORM083135
035-os BibID:	(cikkazonosító)68 (scopus)85078993240 (wos)000519243400011
Első szerző:	Bencze János (orvos)
Cím:	Lemur tyrosine kinase 2 (LMTK2) level inversely correlates with phospho-tau in neuropathological stages of Alzheimer's disease / János Bencze, Máté Szarka, Viktor Bencs, Renáta Nóra Szabó, László V. Módis, Dag Aarsland, Tibor Hortobágyi
Dátum:	2020
Megjegyzések:	Alzheimer's disease (AD) is the most common neurodegenerative dementia. Mapping the pathomechanism and providing novel therapeutic options have paramount significance. Recent studies have proposed the role of LMTK2 in AD. However, its expression pattern and association with the pathognomonic neurofibrillary tangles (NFTs) in different brain regions and neuropathological stages of AD is not clear. We performed chromogenic (CHR) LMTK2 and fluorescent phospho-tau/LMTK2 double-labelling (FDL) immunohistochemistry (IHC) on 10-10 post-mortem middle frontal gyrus (MFG) and anterior hippocampus (aHPC) samples with early and late neuropathological Braak tau stages of AD. MFG in early stage was our ♭endogenous control' region as it is not affected by NFTs. Semi-quantitative CHR-IHC intensity scoring revealed significantly higher (p<0.001) LMTK2 values in this group compared to NFT-affected regions. FDL-IHC demonstrated LMTK2 predominance in the endogenous control region, while phospho-tau overburden and decreased LMTK2 immunolabelling were detected in NFT-affected groups (aHPC in early and both regions in late stage). Spearman's correlation coefficient showed strong negative correlation between phospho-tau/LMTK2 signals within each group. According to our results LMTK2 expression is inversely proportionate to the extent of NFT pathology, as well as decreased LMTK2 level is not a general feature in AD brain, rather it is characteristic to the NFT-affected regions.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk Alzheimer's disease LMTK2 neurodegeneration tau digital image analysis
Megjelenés:	Brain Sciences. - 10 : 2 (2020), p. 1-14. -
További szerzők:	Szarka Máté (1990-) Bencs Viktor (1995-) (orvos) Szabó Renáta Nóra Módis László V. (neurológus) Aarsland, Dag Hortobágyi Tibor (1965-) (patológus)
Pályázati támogatás:	EFOP-3.6.3-VEKOP-16-2017-00009 EFOP ÚNKP-19-3 Egyéb NAP (2017-1.2.1-NKP-2017-00002) Egyéb GINOP-2.3.2-15-2016-00043 GINOP ÚNKP-19-2 Egyéb
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001-es BibID:	BIBFORM081788
035-os BibID:	(cikkazonosító)17222 (WOS)000497712500018 (Scopus)85075476757
Első szerző:	Bencze János (orvos)
Cím:	Neuropathological characterization of Lemur tyrosine kinase 2 (LMTK2) in Alzheimer's disease and neocortical Lewy body disease / János Bencze, Máté Szarka, Viktor Bencs, Renáta Nóra Szabó, Máté Smajda, Dag Aarsland, Tibor Hortobágyi
Dátum:	2019
ISSN:	2045-2322
Megjegyzések:	Alzheimer's disease (AD) and neocortical Lewy body disease (LBD) are the most common neurodegenerative dementias, with no available curative treatment. Elucidating pathomechanism and identifying novel therapeutic targets is of paramount importance. Lemur tyrosine kinase 2 (LMTK2) is involved in several physiological and pathological cellular processes. Herewith a neuropathological characterization is presented in AD and neocortical LBD samples using chromogenic and fluorescent LMTK2 immunohistochemistry on post-mortem brain tissues and compared them to age-matched controls (CNTs). LMTK2 immunopositivity was limited to the neuronal cytoplasm. Neurons, including tau-positive tangle-bearing ones, showed decreased chromogenic and immunofluorescent labelling in AD in every cortical layer compared to CNT and neocortical LBD. Digital image analysis was performed to measure the average immunopositivity of groups. Mean grey values were calculated for each group after measuring the grey scale LMTK2 signal intensity of each individual neuron. There was significant difference between the mean grey values of CNT vs. AD and neocortical LBD vs. AD. The moderate decrease in neocortical LBD suggests the effect of coexisting AD pathology. We provide neuropathological evidence on decreased neuronal LMTK2 immunolabeling in AD, with implications for pathogenesis.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk
Megjelenés:	Scientific Reports. - 9 : 1 (2019), p. 1-9. -
További szerzők:	Szarka Máté (1990-) Bencs Viktor (1995-) (orvos) Szabó Renáta Nóra Smajda Máté Aarsland, Dag Hortobágyi Tibor (1965-) (patológus)
Pályázati támogatás:	EFOP-3.6.3-VEKOP-16-2017-00009 EFOP GINOP-2.3.2-15-2016-00043 GINOP ÚNKP-19-3 Egyéb ÚNKP-18-3 Egyéb ÚNKP-19-2 Egyéb 2017-1.2.1-NKP-2017-00002 MTA
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001-es BibID:	BIBFORM075106
035-os BibID:	(WoS)000471118100019 (Scopus)85052339472
Első szerző:	Vik-Mo, Audun Osland
Cím:	Advanced cerebral amyloid angiopathy and small vessel disease are associated with psychosis in Alzheimer's disease / Vik-Mo Audun Osland, Bencze János, Ballard Clive, Hortobágyi Tibor, Aarsland Dag
Dátum:	2019
ISSN:	0022-3050
Tárgyszavak:	Orvostudományok Klinikai orvostudományok levél folyóiratcikk
Megjelenés:	Journal Of Neurology Neurosurgery And Psychiatry. - 90 : 6 (2019), p. 728-730. -
További szerzők:	Bencze János (1991-) (orvos) Ballard, Clive G. Hortobágyi Tibor (1965-) (patológus) Aarsland, Dag
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