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001-es BibID:	BIBFORM072450
Első szerző:	Szentpéteri Anita (biológus)
Cím:	Serum obestatin level strongly correlates with lipoprotein subfractions in non-diabetic obese patients / Anita Szentpéteri, Hajnalka Lőrincz, Sándor Somodi, Viktória Evelin Varga, György Paragh Jr., Ildikó Seres, György Paragh, Mariann Harangi
Dátum:	2018
ISSN:	1476-511X
Megjegyzések:	Background: Obestatin is a ghrelin-associated peptide, derived from preproghrelin. Although many of its effects are unclear, accumulating evidence supports positive actions on both metabolism and cardiovascular function. To date, level of obestatin and its correlations to the lipid subfractions in non-diabetic obese (NDO) patients have not been investigated. Methods: Fifty NDO patients (BMI: 41.96?8.6 kg/m2) and thirty-two normal-weight, age- and gender-matched healthy controls (BMI: 24.16?3.3 kg/m2) were enrolled into our study. Obestatin level was measured by ELISA. Low-density lipoprotein (LDL) and high-density lipoprotein (HDL) subfractions, intermediate density lipoprotein (IDL) and very low-density lipoprotein (VLDL) levels and mean LDL size were detected by nongradient polyacrylamide gel electrophoresis (Lipoprint).Results: Serum level of obestatin was significantly lower in NDO patients compared to controls (3.01?0.5 vs. 3.29?0.6 ?g/ml, p<0.05). We found significant negative correlations between the level of obestatin and BMI (r=-0.33; p<0.001), level of serum glucose (r=-0.27, p<0.05), HbA1c (r=-0.38; p<0.001) and insulin (r=-0.34; p<0.05). Significant positive correlation was found between obestatin level and the levels of ApoA1 (r=0.25; p<0.05), large HDL subfraction ratio and level (r=0.23; p<0.05 and r=0.24; p<0.05), IDL (r=0.25 p<0.05) and mean LDL size (r=0.25; p<0.05). Serum VLDL ratio and level negatively correlated with obestatin (r=-0.32; p<0.01 and r=-0.21; p=0.05). In multiple regression analysis obestatin was predicted only by VLDL level.Conclusions: Based on our data, measurement of obestatin level in obesity may contribute to understand the interplay between gastrointestinal hormone secretion and metabolic alterations in obesity.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban obestatin metabolic syndrome diabetes obesity hyperlipidemia
Megjelenés:	Lipids in Health and Disease. - 17 : 1 (2018), p. 1-27. -
További szerzők:	Lőrincz Hajnalka (1986-) (biológus) Somodi Sándor (1977-) (belgyógyász) Varga Viktória Evelin (1988-) (biológus) Paragh György Jr. (1978-) (bőrgyógyász) Seres Ildikó (1954-) (biokémikus) Paragh György (1953-) (belgyógyász) Harangi Mariann (1974-) (belgyógyász, endokrinológus)
Pályázati támogatás:	GINOP-2.3.2-15-2016-00005 GINOP 115723 OTKA
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat DOI Szerző által megadott URL
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001-es BibID:	BIBFORM073991
Első szerző:	Varga Viktória Evelin (biológus)
Cím:	Changes in serum afamin and vitamin E levels after selective LDL apheresis / Varga Viktória Evelin, Lőrincz Hajnalka, Szentpéteri Anita, Juhász Lilla, Seres Ildikó, Paragh György Jr., Balla József, Paragh György, Harangi Mariann
Dátum:	2018
ISSN:	0733-2459
Megjegyzések:	Background: Human afamin is a plasma vitamin E-binding glycoprotein partially associatedwith ApoA1-containing HDL subfractions. In a previous study, the serum vitamin Edecreased after LDL apheresis, while vitamin E/cholesterol ratio significantly increased. Weaimed to study the effect of LDL apheresis on serum afamin level.Methods: The serum level of afamin and oxidized LDL were measured by enzyme-linkedimmunosorbent assay in six severe heterozygous FH patients before and after their first LDLapheresis treatments and in seven healthy controls. We also investigated the changes in HDLsubfractions and ApoA1, ?- and ?-tocopherol levels during the treatment. HDL subfractionswere detected by an electrophoretic method on polyacrylamide gel (Lipoprint). Serum ?- and?-tocopherol levels were detected by gas chromatography-mass spectrometry.Results: The first treatment sessions decreased serum afamin levels by an average of 9.4%.Total cholesterol, LDL-C, HDL-C and ApoA1 levels decreased by 52.6; 61.8; 10.5 and14.1%, respectively. We found that ?- and ?-tocopherol levels markedly decreased (by 34.1and 32.9%, respectively), while ?- tocopherol/cholesterol and ?-tocopherol/cholesterol ratiossignificantly increased (by 41.4 and 40.3%, respectively). Furthermore, oxidized LDL levelssignificantly decreased and there was a shift towards the larger HDL subfractions.Conclusion: LDL apheresis moderately decreases the circulating levels of afamin parallel tolowering HDL-C and ApoA1 levels. Tocopherol levels decreases markedly compared toafamin levels, however, beneficial changes in vitamin E/cholesterol ratios, oxidized LDLlevels and HDL subfraction distribution were detected. These additional effects of LDLapheresis may result in further cardiovascular risk reduction in FH patients.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban LDL apheresis vitamin E afamin ApoA1 Familial Hypercholesterolemia
Megjelenés:	Journal Of Clinical Apheresis. - 33 : 5 (2018), p. 569-575. -
További szerzők:	Lőrincz Hajnalka (1986-) (biológus) Szentpéteri Anita (1988-) (biológus) Juhász Lilla (1990-) (általános orvos) Seres Ildikó (1954-) (biokémikus) Paragh György Jr. (1978-) (bőrgyógyász) Balla József (1959-) (belgyógyász, nephrológus) Paragh György (1953-) (belgyógyász) Harangi Mariann (1974-) (belgyógyász, endokrinológus)
Pályázati támogatás:	GINOP-2.3.2-15-2016-00005 GINOP OTKA-115723 OTKA
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat DOI
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