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001-es BibID:BIBFORM059606
Első szerző:Lontay Beáta (biokémikus)
Cím:Pregnancy and Smoothelin-like Protein 1 (SMTNL1) Deletion Promote the Switching of Skeletal Muscle to a Glycolytic Phenotype in Human and Mice / Lontay Beata, Bodoor Khaldon, Sipos Adrienn, Weitzel Douglas H., Loiselle David, Safi Rachid, Zheng Donghai, Devente James, Hickner Robert C., McDonnell Donald P., Ribar Thomas, Haystead Timothy A.
Dátum:2015
ISSN:0021-9258 1083-351X
Megjegyzések:Pregnancy promotes physiological adaptations throughout the body, mediated by the female sex hormones progesterone and estrogen. Changes in the metabolic properties of skeletal muscle enable the female body to cope with the physiological challenges of pregnancy and may also be linked to the development of insulin resistance. We conducted global microarray, proteomic, and metabolic analyses to study the role of the progesterone receptor and its transcriptional regulator, smoothelin-like protein 1 (SMTNL1) in the adaptation of skeletal muscle to pregnancy. We demonstrate that pregnancy promotes fiber-type changes from an oxidative to glycolytic isoform in skeletal muscle. This phenomenon is regulated through an interaction between SMTNL1 and progesterone receptor, which alters the expression of contractile and metabolic proteins. smtnl1(-/-) mice are metabolically less efficient and show impaired glucose tolerance. Pregnancy antagonizes these effects by inducing metabolic activity and increasing glucose tolerance. Our results suggest that SMTNL1 has a role in mediating the actions of steroid hormones to promote fiber switching in skeletal muscle during pregnancy. Our findings also bear on the management of gestational diabetes that develops as a complication of pregnancy in -4% of women.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
gene expression
proteomics
pregnancy
skeletal muscle
smoothelin-like protein 1
steroid hormone receptor
Megjelenés:Journal Of Biological Chemistry 290 : 29 (2015), p. 17985-17998. -
További szerzők:Bodoor, Khaldon Sipos Adrienn (1984-) (biológus, biotechnológus) Weitzel, Douglas H. Loiselle, David Safi, Rachid Zheng, Donghai Devente, James Hickner, Robert C. McDonnell, Donald P. Ribar, Thomas Haystead, Timothy A. J.
Pályázati támogatás:TÁMOP-4.2.2.A-11/1/KONV-2012-0025
TÁMOP
TÁMOP-4.2.4.A/2-11-1-2012-0001
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