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1.
001-es BibID:
BIBFORM108755
035-os BibID:
(scopus)85146738441 (WOS)000922305000002
Első szerző:
Berkowicz, Piotr
Cím:
Accelerated ageing and coronary microvascular dysfunction in chronic heart failure in Tgαq*44 mice / Berkowicz Piotr, Totoń-Żurańska Justyna, Kwiatkowski Grzegorz, Jasztal Agnieszka, Csípő Tamás, Kus Kamil, Tyrankiewicz Urszula, Orzyłowska Anna, Wołkow Paweł, Tóth Attila, Chlopicki Stefan
Dátum:
2023
ISSN:
2509-2715 2509-2723
Tárgyszavak:
Orvostudományok
Klinikai orvostudományok
idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:
GeroScience. - 45 : 3 (2023), p. 1619-1648. -
További szerzők:
Totoń-Żurańska, Justyna
Kwiatkowski, Grzegorz
Jasztal, Agnieszka
Csípő Tamás (1990-)
Kus, Kamil
Tyrankiewicz, Urszula
Orzyłowska, Anna
Wołkow, Paweł
Tóth Attila (1971-) (biológus)
Chlopicki, Stefan
Internet cím:
Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
Borító:
Saját polcon:
2.
001-es BibID:
BIBFORM099947
035-os BibID:
(WOS)000493706100001 (Scopus)85074834329
Első szerző:
Csípő Tamás
Cím:
Assessment of age-related decline of neurovascular coupling responses by functional near-infrared spectroscopy (fNIRS) in humans / Csipo Tamas, Mukli Peter, Lipecz Agnes, Tarantini Stefano, Bahadli Dhay, Abdulhussein Osamah, Owens Cameron, Kiss Tamas, Balasubramanian Priya, Nyúl-Tóth Ádám, Hand Rachel A., Yabluchanska Valeriya, Sorond Farzaneh A., Csiszar Anna, Ungvari Zoltan, Yabluchanskiy Andriy
Dátum:
2019
ISSN:
2509-2715 2509-2723
Megjegyzések:
Preclinical studies provide strong evidence that age-related impairment of neurovascular coupling (NVC) plays a causal role in the pathogenesis of vascular cognitive impairment (VCI). NVC is a critical homeostatic mechanism in the brain, responsible for adjustment of local cerebral blood flow to the energetic needs of the active neuronal tissue. Recent progress in geroscience has led to the identification of critical cellular and molecular mechanisms involved in neurovascular aging, identifying these pathways as targets for intervention. In order to translate the preclinical findings to humans, there is a need to assess NVC in geriatric patients as an endpoint in clinical studies. Functional near-infrared spectroscopy (fNIRS) is a non-invasive neuroimaging technique that enables the investigation of local changes in cerebral blood flow, quantifying task-related changes in oxygenated and deoxygenated hemoglobin concentrations. In the present overview, the basic principles of fNIRS are introduced and the application of this technique to assess NVC in older adults with implications for the design of studies on the mechanistic underpinnings of VCI is discussed.
Tárgyszavak:
Orvostudományok
Elméleti orvostudományok
idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Aging
Cognitive aging
Functional near-infrared spectroscopy
Neurovascular coupling
VCI
VCID
Vascular cognitive impairment and dementia
fNIRS
Megjelenés:
GeroScience. - 41 : 5 (2019), p. 495-509. -
További szerzők:
Mukli Péter
Lipécz Ágnes
Tarantini, Stefano
Bahadli, Dhay
Abdulhussein, Osamah
Owens, Cameron D.
Kiss Tamás (1950-) (vegyész)
Balasubramanian, Priya
Nyúl-Tóth Ádám
Hand, Rachel A.
Yabluchanska, Valeriya
Sorond, Farzaneh A.
Csiszár Anna
Ungvári Zoltán
Yabluchanskiy, Andriy
Internet cím:
Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
Borító:
Saját polcon:
3.
001-es BibID:
BIBFORM099943
035-os BibID:
(WOS)000469877700003 (Scopus)85066471327
Első szerző:
Csípő Tamás
Cím:
Age-related decline in peripheral vascular health predicts cognitive impairment / Csipo Tamas, Lipecz Agnes, Fulop Gabor A., Hand Rachel A., Ngo Bich-Thy N., Dzialendzik Mikita, Tarantini Stefano, Balasubramanian Priya, Kiss Tamas, Yabluchanska Valeriya, Silva-Palacios Federico, Courtney Donald L., Dasari Tarun W., Sorond Farzaneh, Sonntag William E., Csiszar Anna, Ungvari Zoltan, Yabluchanskiy Andriy
Dátum:
2019
ISSN:
2509-2715 2509-2723
Megjegyzések:
Preclinical studies demonstrate that generalized endothelial cell dysfunction and microvascular impairment are potentially reversible causes of age-related vascular cognitive impairment and dementia (VCID). The present study was designed to test the hypothesis that severity of age-related macro- and microvascular dysfunction measured in the peripheral circulation is an independent predictor of cognitive performance in older adults. In this study, we enrolled 63 healthy individuals into young (< 45 years old) and aged (> 65 years old) groups. We used principal component analysis (PCA) to construct a comprehensive peripheral vascular health index (VHI) encompassing peripheral microvascular reactivity, arterial endothelial function, and vascular stiffness, as a marker of aging-induced generalized vascular dysfunction. Peripheral macrovascular and microvascular endothelial function were assessed using flow-mediated dilation (FMD) and laser speckle contrast imaging tests. Pulse waveform analysis was used to evaluate the augmentation index (AIx), a measure of arterial stiffness. Cognitive function was measured using a panel of CANTAB cognitive tests, and PCA was then applied to generate a cognitive impairment index (CII) for each participant. Aged subjects exhibited significantly impaired macrovascular endothelial function (FMD, 5.6 ? 0.7% vs. 8.3 ? 0.6% in young, p = 0.0061), increased arterial stiffness (AIx 29.3 ? 1.8% vs 4.5 ? 2.6% in young, p < 0.0001), and microvascular dysfunction (2.8 ? 0.2 vs 3.4 ? 0.1-fold change of perfusion in young, p = 0.032). VHI showed a significant negative correlation with age (r = - 0.54, p < 0.0001) and CII significantly correlated with age (r = 0.79, p < 0.0001). VHI significantly correlated with the CII (r = - 0.46, p = 0.0003). A decline in peripheral vascular health may reflect generalized vascular dysfunction and predict cognitive impairment in older adults.
Tárgyszavak:
Orvostudományok
Elméleti orvostudományok
idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Aging
Endothelial function
Cognitive impairment
Microvascular dysfunction
VCID
Megjelenés:
GeroScience. - 41 : 2 (2019), p. 125-136. -
További szerzők:
Lipécz Ágnes
Fülöp Gábor Áron (1988-) (általános orvos)
Hand, Rachel A.
Ngo, Bich-Thy N.
Dzialendzik, Mikita
Tarantini, Stefano
Balasubramanian, Priya
Kiss Tamás (1950-) (vegyész)
Yabluchanska, Valeriya
Silva-Palacios, Federico
Courtney, Donald L.
Dasari, Tarun W.
Sorond, Farzaneh A.
Sonntag, William E.
Csiszár Anna
Ungvári Zoltán
Yabluchanskiy, Andriy
Internet cím:
Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
Borító:
Saját polcon:
4.
001-es BibID:
BIBFORM076737
035-os BibID:
(WOS)000440106900010 (Scopus)85048661448
Első szerző:
Csípő Tamás
Cím:
Short-term weight loss reverses obesity-induced microvascular endothelial dysfunction / Tamas Csipo, Gabor A. Fulop, Agnes Lipecz, Stefano Tarantini, Tamas Kiss, Priya Balasubramanian, Anna Csiszar, Zoltan Ungvari, Andriy Yabluchanskiy
Dátum:
2018
ISSN:
2509-2715 2509-2723
Megjegyzések:
Obesity is one of the major risk factors for cardiovascular diseases and its prevalence is increasing in all age groups, with the biggest impact observed in middle-aged and older adults. A critical mechanism by which obesity promotes vascular pathologies in these patients involves impairment of endothelial function. While endothelial dysfunction in large vessels promotes atherogenesis, obesity-induced microvascular endothelial dysfunction impairs organ perfusion and thereby is causally related to the pathogenesis of ischemic heart disease, chronic kidney disease, intermittent claudication, exercise intolerance, and exacerbates cognitive decline in aging. Reduction of weight via calorie-based diet and exercise in animal models of obesity results in significant improvement of endothelial function both in large vessels and in the microcirculation, primarily due to attenuation of oxidative stress and inflammation. Clinical data on the protective effects of weight loss on endothelial function is limited to studies of flow-mediated dilation assessed in brachial arteries. Currently, there is no guideline on testing the effects of different weight management strategies on microvascular endothelial function in obese patients. Here, we provide proof-of-concept that weight loss-induced improvement of microvascular endothelial function can be reliably assessed in the setting of a geriatric outpatient clinic using a fast, reproducible, non-invasive method: laser speckle contrast imaging-based measurement of endothelium-dependent microvascular responses during post-occlusive reactive hyperemia tests. Our study also provides initial evidence that short-term weight loss induced by consumption of a low-carbohydrate low-calorie diet can reverse microvascular endothelial dysfunction associated with obesity.
Tárgyszavak:
Orvostudományok
Klinikai orvostudományok
idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Weight loss
Obesity
Endothelial function
Aging
Megjelenés:
GeroScience. - 40 : 3 (2018), p. 337-346. -
További szerzők:
Fülöp Gábor Áron (1988-) (általános orvos)
Lipécz Ágnes
Tarantini, Stefano
Kiss Tamás
Balasubramanian, Priya
Csiszár Anna
Ungvári Zoltán
Yabluchanskiy, Andriy
Internet cím:
Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
Borító:
Saját polcon:
5.
001-es BibID:
BIBFORM082128
035-os BibID:
(WOS)000494370900001 (Scopus)85074926339
Első szerző:
Fülöp Gábor Áron (általános orvos)
Cím:
Cerebral venous congestion promotes blood-brain barrier disruption and neuroinflammation, impairing cognitive function in mice / Gabor A. Fulop, Chetan Ahire, Tamas Csipo, Stefano Tarantini, Tamas Kiss, Priya Balasubramanian, Andriy Yabluchanskiy, Eszter Farkas, Attila Toth, Ádám Nyúl-Tóth, Peter Toth, Anna Csiszar, Zoltan Ungvari
Dátum:
2019
ISSN:
2509-2715 2509-2723
Tárgyszavak:
Orvostudományok
Klinikai orvostudományok
idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:
GeroScience. - 41 : 5 (2019), p. 575-589. -
További szerzők:
Ahire, Chetan
Csípő Tamás (1990-)
Tarantini, Stefano
Kiss Tamás
Balasubramanian, Priya
Yabluchanskiy, Andriy
Farkas Eszter
Tóth Attila (1971-) (biológus)
Nyúl-Tóth Ádám
Tóth Péter
Csiszár Anna
Ungvári Zoltán
Pályázati támogatás:
EFOP-3.6.1-16-2016-00008, 20765-3/2018/FEKUTSTRAT
EFOP
EFOP-3.6.2.-16-2017-00008
EFOP
GINOP-2.3.2-15-2016-00048
GINOP
GINOP-2.3.3-15-2016-00032
GINOP
NKFI-FK123798
NKFIH
Internet cím:
Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
Borító:
Saját polcon:
6.
001-es BibID:
BIBFORM099929
035-os BibID:
(WOS)000531041500024 (Scopus)85082710654
Első szerző:
Kiss Tamás (vegyész)
Cím:
Circulating anti-geronic factors from heterochonic parabionts promote vascular rejuvenation in aged mice : transcriptional footprint of mitochondrial protection, attenuation of oxidative stress, and rescue of endothelial function by young blood / Kiss Tamas, Tarantini Stefano, Csipo Tamas, Balasubramanian Priya, Nyúl-Tóth Ádám, Yabluchanskiy Andriy, Wren Jonathan D., Garman Lori, Huffman Derek M., Csiszar Anna, Ungvari Zoltan
Dátum:
2020
ISSN:
2509-2715 2509-2723
Megjegyzések:
Aging-induced functional and phenotypic alterations of the vasculature (e.g., endothelial dysfunction, oxidative stress) have a central role in morbidity and mortality of older adults. It has become apparent in recent years that cell autonomous mechanisms alone are inadequate to explain all aspects of vascular aging. The present study was designed to test the hypothesis that age-related changes in circulating anti-geronic factors contribute to the regulation of vascular aging processes in a non-cell autonomous manner. To test this hypothesis, through heterochronic parabiosis we determined the extent, if any, to which endothelial function, vascular production of ROS, and shifts in the vascular transcriptome (RNA-seq) are modulated by the systemic environment. We found that in aortas isolated from isochronic parabiont aged (20-month-old) C57BL/6 mice [A-(A); parabiosis for 8 weeks] acetylcholine-induced endothelium-dependent relaxation was impaired and ROS production (dihydroethidium fluorescence) was increased as compared with those in aortas from young isochronic parabiont (6-month-old) mice [Y-(Y)]. The presence of young blood derived from young parabionts significantly improved endothelium-dependent vasorelaxation and attenuated ROS production in vessels of heterochronic parabiont aged [A-(Y)] mice. In aortas derived from heterochronic parabiont young [Y-(A)] mice, acetylcholine-induced relaxation and ROS production were comparable with those in aortas derived from Y-(Y) mice. Using RNA-seq we assessed transcriptomic changes in the aortic arch associated with aging and heterochronic parabiosis. We identified 347 differentially expressed genes in A-(A) animals compared with Y-(Y) controls. We have identified 212 discordant genes, whose expression levels differed in the aged phenotype, but have shifted back toward the young phenotype by the presence of young blood in aged A-(Y) animals. Pathway analysis shows that vascular protective effects mediated by young blood-regulated genes include mitochondrial rejuvenation. In conclusion, a relatively short-term exposure to young blood can rescue vascular aging phenotypes, including attenuation of oxidative stress, mitochondrial rejuvenation, and improved endothelial function. Our findings provide additional evidence supporting the significant plasticity of vascular aging and evidence for the existence of anti-geronic factors capable of exerting rejuvenating effects on the aging vasculature.
Tárgyszavak:
Orvostudományok
Elméleti orvostudományok
idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:
GeroScience. - 42 : 2 (2020), p. 727-748. -
További szerzők:
Tarantini, Stefano
Csípő Tamás (1990-)
Balasubramanian, Priya
Nyúl-Tóth Ádám
Yabluchanskiy, Andriy
Wren, Jonathan D.
Garman, Lori
Huffman, Derek M.
Csiszár Anna
Ungvári Zoltán
Internet cím:
Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
Borító:
Saját polcon:
7.
001-es BibID:
BIBFORM099926
035-os BibID:
(WOS)000522703800001 (Scopus)85083217977
Első szerző:
Kiss Tamás (vegyész)
Cím:
Single-cell RNA sequencing identifies senescent cerebromicrovascular endothelial cells in the aged mouse brain / Kiss Tamas, Nyúl-Tóth Ádám, Balasubramanian Priya, Tarantini Stefano, Ahire Chetan, DelFavero Jordan, Yabluchanskiy Andriy, Csipo Tamas, Farkas Eszter, Wiley Graham, Garman Lori, Csiszar Anna, Ungvari Zoltan
Dátum:
2020
ISSN:
2509-2715 2509-2723
Megjegyzések:
Age-related phenotypic changes of cerebromicrovascular endothelial cells lead to dysregulation of cerebral blood flow and blood-brain barrier disruption, promoting the pathogenesis of vascular cognitive impairment (VCI). In recent years, endothelial cell senescence has emerged as a potential mechanism contributing to microvascular pathologies opening the avenue to the therapeutic exploitation of senolytic drugs in preclinical studies. However, difficulties with the detection of senescent endothelial cells in wild type mouse models of aging hinder the assessment of the efficiency of senolytic treatments. To detect senescent endothelial cells in the aging mouse brain, we analyzed 4233 cells in fractions enriched for cerebromicrovascular endothelial cells and other cells associated with the neurovascular unit obtained from young (3-month-old) and aged (28-month-old) C57BL/6 mice. We define 13 transcriptomic cell types by deep, single-cell RNA sequencing. We match transcriptomic signatures of cellular senescence to endothelial cells identified on the basis of their gene expression profile. Our study demonstrates that with advanced aging, there is an increased ratio of senescent endothelial cells (~ 10%) in the mouse cerebral microcirculation. We propose that our single-cell RNA sequencing-based method can be adapted to study the effect of aging on senescence in various brain cell types as well as to evaluate the efficiency of various senolytic regimens in multiple tissues.
Tárgyszavak:
Orvostudományok
Elméleti orvostudományok
idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Aging
Blood-brain barrier
Geroscience
Senescence
Vascular cognitive impairment
Megjelenés:
GeroScience. - 42 : 2 (2020), p. 429-444. -
További szerzők:
Nyúl-Tóth Ádám
Balasubramanian, Priya
Tarantini, Stefano
Ahire, Chetan
DelFavero, Jordan
Yabluchanskiy, Andriy
Csípő Tamás (1990-)
Farkas Eszter
Wiley, Graham
Garman, Lori
Csiszár Anna
Ungvári Zoltán
Internet cím:
Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
Borító:
Saját polcon:
8.
001-es BibID:
BIBFORM099925
035-os BibID:
(WOS)000516267700001 (Scopus)85079528822
Első szerző:
Kiss Tamás (vegyész)
Cím:
Nicotinamide mononucleotide (NMN) supplementation promotes neurovascular rejuvenation in aged mice : transcriptional footprint of SIRT1 activation, mitochondrial protection, anti-inflammatory, and anti-apoptotic effects / Kiss Tamas, Nyúl-Tóth Ádám, Balasubramanian Priya, Tarantini Stefano, Ahire Chetan, Yabluchanskiy Andriy, Csipo Tamas, Farkas Eszter, Wren Jonathan D., Garman Lori, Csiszar Anna, Ungvari Zoltan
Dátum:
2020
ISSN:
2509-2715 2509-2723
Megjegyzések:
Aging-induced structural and functional alterations of the neurovascular unit lead to impairment of neurovascular coupling responses, dysregulation of cerebral blood flow, and increased neuroinflammation, all of which contribute importantly to the pathogenesis of age-related vascular cognitive impairment (VCI). There is increasing evidence showing that a decrease in NAD+ availability with age plays a critical role in age-related neurovascular and cerebromicrovascular dysfunction. Our recent studies demonstrate that restoring cellular NAD+ levels in aged mice rescues neurovascular function, increases cerebral blood flow, and improves performance on cognitive tasks. To determine the effects of restoring cellular NAD+ levels on neurovascular gene expression profiles, 24-month-old C57BL/6 mice were treated with nicotinamide mononucleotide (NMN), a key NAD+ intermediate, for 2 weeks. Transcriptome analysis of preparations enriched for cells of the neurovascular unit was performed by RNA-seq. Neurovascular gene expression signatures in NMN-treated aged mice were compared with those in untreated young and aged control mice. We identified 590 genes differentially expressed in the aged neurovascular unit, 204 of which are restored toward youthful expression levels by NMN treatment. The transcriptional footprint of NMN treatment indicates that increased NAD+ levels promote SIRT1 activation in the neurovascular unit, as demonstrated by analysis of upstream regulators of differentially expressed genes as well as analysis of the expression of known SIRT1-dependent genes. Pathway analysis predicts that neurovascular protective effects of NMN are mediated by the induction of genes involved in mitochondrial rejuvenation, anti-inflammatory, and anti-apoptotic pathways. In conclusion, the recently demonstrated protective effects of NMN treatment on neurovascular function can be attributed to multifaceted sirtuin-mediated anti-aging changes in the neurovascular transcriptome. Our present findings taken together with the results of recent studies using mitochondria-targeted interventions suggest that mitochondrial rejuvenation is a critical mechanism to restore neurovascular health and improve cerebral blood flow in aging.
Tárgyszavak:
Orvostudományok
Elméleti orvostudományok
idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Aging
Geroscience
Mitochondria dysfunction
Transcriptomics
Vascular cognitive impairment
Megjelenés:
GeroScience. - 42 : 2 (2020), p. 527-546. -
További szerzők:
Nyúl-Tóth Ádám
Balasubramanian, Priya
Tarantini, Stefano
Ahire, Chetan
Yabluchanskiy, Andriy
Csípő Tamás (1990-)
Farkas Eszter
Wren, Jonathan D.
Garman, Lori
Csiszár Anna
Ungvári Zoltán
Internet cím:
Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
Borító:
Saját polcon:
9.
001-es BibID:
BIBFORM099948
035-os BibID:
(WOS)000500795500001 (Scopus)85075945416
Első szerző:
Lipécz Ágnes
Cím:
Microvascular contributions to age-related macular degeneration (AMD) : from mechanisms of choriocapillaris aging to novel interventions / Lipecz Agnes, Miller Lauren, Kovacs Illes, Czakó Cecília, Csipo Tamas, Baffi Judit, Csiszar Anna, Tarantini Stefano, Ungvari Zoltan, Yabluchanskiy Andriy, Conley Shannon
Dátum:
2019
ISSN:
2509-2715 2509-2723
Megjegyzések:
Aging of the microcirculatory network plays a central role in the pathogenesis of a wide range of age-related diseases, from heart failure to Alzheimer's disease. In the eye, changes in the choroid and choroidal microcirculation (choriocapillaris) also occur with age, and these changes can play a critical role in the pathogenesis of age-related macular degeneration (AMD). In order to develop novel treatments for amelioration of choriocapillaris aging and prevention of AMD, it is essential to understand the cellular and functional changes that occur in the choroid and choriocapillaris during aging. In this review, recent advances in in vivo analysis of choroidal structure and function in AMD patients and patients at risk for AMD are discussed. The pathophysiological roles of fundamental cellular and molecular mechanisms of aging including oxidative stress, mitochondrial dysfunction, and impaired resistance to molecular stressors in the choriocapillaris are also considered in terms of their contribution to the pathogenesis of AMD. The pathogenic roles of cardiovascular risk factors that exacerbate microvascular aging processes, such as smoking, hypertension, and obesity as they relate to AMD and choroid and choriocapillaris changes in patients with these cardiovascular risk factors, are also discussed. Finally, future directions and opportunities to develop novel interventions to prevent/delay AMD by targeting fundamental cellular and molecular aging processes are presented.
Tárgyszavak:
Orvostudományok
Elméleti orvostudományok
idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Cardiovascular risk factors
Choroidal thickness
Hypertension
OCTA
Retina
SD-OCT
Smoking
Megjelenés:
GeroScience. - 41 : 6 (2019), p. 813-845. -
További szerzők:
Miller, Lauren
Kovács Illés
Czakó Cecília
Csípő Tamás (1990-)
Baffi Judit
Csiszár Anna
Tarantini, Stefano
Ungvári Zoltán
Yabluchanskiy, Andriy
Conley, Shannon M.
Internet cím:
Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
Borító:
Saját polcon:
10.
001-es BibID:
BIBFORM099944
035-os BibID:
(WOS)000481790700008 (Scopus)85070755106
Első szerző:
Lipécz Ágnes
Cím:
Age-related impairment of neurovascular coupling responses : a dynamic vessel analysis (DVA)-based approach to measure decreased flicker light stimulus-induced retinal arteriolar dilation in healthy older adults / Lipecz Agnes, Csipo Tamas, Tarantini Stefano, Hand Rachel A., Ngo Bich-Thy N., Conley Shannon, Nemeth Gabor, Tsorbatzoglou Alexis, Courtney Donald L., Yabluchanska Valeriya, Csiszar Anna, Ungvari Zoltan I., Yabluchanskiy Andriy
Dátum:
2019
ISSN:
2509-2715 2509-2723
Megjegyzések:
Aging is a major risk factor for vascular cognitive impairment and dementia (VCID). Recent studies demonstrate that cerebromicrovascular dysfunction plays a causal role in the development of age-related cognitive impairment, in part via disruption of neurovascular coupling (NVC) responses. NVC (functional hyperemia) is responsible for adjusting cerebral blood flow to the increased energetic demands of activated neurons, and in preclinical animal models of aging, pharmacological restoration of NVC is associated with improved cognitive performance. To translate these findings, there is an increasing need to develop novel and sensitive tools to assess cerebromicrovascular function and NVC to assess risk for VCID and evaluate treatment efficacy. Due to shared developmental origins, anatomical features, and physiology, assessment of retinal vessel function may serve as an important surrogate outcome measure to study neurovascular dysfunction. The present study was designed to compare NVC responses in young (< 45 years of age; n = 18) and aged (> 65 years of age; n = 11) healthy human subjects by assessing flicker light-induced changes in the diameter of retinal arterioles using a dynamic vessel analyzer (DVA)-based approach. We found that NVC responses in retinal arterioles were significantly decreased in older adults as compared with younger subjects. We propose that the DVA-based approach can be used to assess NVC, as a surrogate cerebromicrovascular outcome measure, to evaluate the effects of therapeutic interventions in older individuals.
Tárgyszavak:
Orvostudományok
Elméleti orvostudományok
idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Aging
Dynamic retinal vessel analysis
Endothelial dysfunction
Neurovascular coupling
Vascular cognitive impairment and dementia
Megjelenés:
GeroScience. - 41 : 3 (2019), p. 341-349. -
További szerzők:
Csípő Tamás (1990-)
Tarantini, Stefano
Hand, Rachel A.
Ngo, Bich-Thy N.
Conley, Shannon M.
Németh Gábor (1975-) (szemész)
Tsorbatzoglou, Alexis (1970-) (szemész)
Courtney, Donald L.
Yabluchanska, Valeriya
Csiszár Anna
Ungvári Zoltán
Yabluchanskiy, Andriy
Internet cím:
Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
Borító:
Saját polcon:
11.
001-es BibID:
BIBFORM082129
035-os BibID:
(WOS)000493693900001 (Scopus)85074812973
Első szerző:
Tarantini, Stefano
Cím:
Treatment with the poly(ADP-ribose) polymerase inhibitor PJ-34 improves cerebromicrovascular endothelial function, neurovascular coupling responses and cognitive performance in aged mice, supporting the NAD+ depletion hypothesis of neurovascular aging / Tarantini Stefano, Yabluchanskiy Andriy, Csipo Tamas, Fulop Gabor, Kiss Tamas, Balasubramanian Priya, DelFavero Jordan, Ahire Chetan, Ungvari Anna, Nyúl-Tóth Ádám, Farkas Eszter, Benyo Zoltan, Tóth Attila, Csiszar Anna, Ungvari Zoltan
Dátum:
2019
ISSN:
2509-2715 2509-2723
Megjegyzések:
Adjustment of cerebral blood flow (CBF) to neuronal activity via neurovascular coupling (NVC) plays an important role in the maintenance of healthy cognitive function. Strong evidence demonstrates that age-related cerebromicrovascular endothelial dysfunction and consequential impairment of NVC responses contribute importantly to cognitive decline. Recent studies demonstrate that NAD(+) availability decreases with age in the vasculature and that supplemental NAD(+) precursors can ameliorate cerebrovascular dysfunction, rescuing NVC responses and improving cognitive performance in aged mice. The mechanisms underlying the age-related decline in [NAD(+)] in cells of the neurovascular unit are likely multifaceted and may include increased utilization of NAD(+) by activated poly (ADP-ribose) polymerase (PARP-1). The present study was designed to test the hypothesis that inhibition of PARP-1 activity may confer protective effects on neurovascular function in aging, similar to the recently demonstrated protective effects of treatment with the NAD+ precursor nicotinamide mononucleotide (NMN). To test this hypothesis, 24-month-old C57BL/6 mice were treated with PJ-34, a potent PARP inhibitor, for 2 weeks. NVC was assessed by measuring CBF responses (laser speckle contrast imaging) in the somatosensory whisker barrel cortex evoked by contralateral whisker stimulation. We found that NVC responses were significantly impaired in aged mice. Treatment with PJ-34 improved NVC responses by increasing endothelial NO-mediated vasodilation, which was associated with significantly improved spatial working memory. PJ-34 treatment also improved endothelium-dependent acetylcholine-induced relaxation of aorta rings. Thus, PARP-1 activation, likely by decreasing NAD(+) availability, contributes to age-related endothelial dysfunction and neurovascular uncoupling, exacerbating cognitive decline. The cerebromicrovascular protective effects of pharmacological inhibition of PARP-1 highlight the preventive and therapeutic potential of treatments that restore NAD+ homeostasis as effective interventions in patients at risk for vascular cognitive impairment (VCI).
Tárgyszavak:
Orvostudományok
Elméleti orvostudományok
idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Cellular energetics
Oxidative stress
ROS
Endothelial dysfunction
Functional hyperemia
Microcirculation
Senescence
Megjelenés:
GeroScience. - 41 : 5 (2019), p. 533-542. -
További szerzők:
Yabluchanskiy, Andriy
Csípő Tamás (1990-)
Fülöp Gábor Áron (1988-) (általános orvos)
Kiss Tamás
Balasubramanian, Priya
DelFavero, Jordan
Ahire, Chetan
Ungvári Anna
Nyúl-Tóth Ádám
Farkas Eszter
Benyó Zoltán
Tóth Attila (1971-) (biológus)
Csiszár Anna
Ungvári Zoltán
Internet cím:
Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
Borító:
Saját polcon:
12.
001-es BibID:
BIBFORM117425
035-os BibID:
(Scopus)85179338215 (WoS)001115572500001
Első szerző:
Ungvári Zoltán
Cím:
The Semmelweis Study : a longitudinal occupational cohort study within the framework of the Semmelweis Caring University Model Program for supporting healthy aging / Zoltan Ungvari, Adam G. Tabák, Roza Adany, György Purebl, Csilla Kaposvári, Vince Fazekas-Pongor, Tamás Csípő, Zsófa Szarvas, Krisztián Horváth, Peter Mukli, Piroska Balog, Robert Bodizs, Peter Ujma, Adrienne Stauder, Daniel W. Belsky, Illés Kovács, Andriy Yabluchanskiy, Andrea B. Maier, Mariann Moizs, Piroska Östlin, Yongjie Yon, Péter Varga, Zoltán Vokó, Magor Papp, István Takács, Barna Vásárhelyi, Péter Torzsa, Péter Ferdinandy, Anna Csiszar, Zoltán Benyó, Attila J. Szabó, Gabriella Dörnyei, Mika Kivimäki, Miklos Kellermayer, Bela Merkely
Dátum:
2024
ISSN:
2509-2715 2509-2723
Megjegyzések:
The Semmelweis Study is a prospective occupational cohort study that seeks to enroll all employees of Semmelweis University (Budapest, Hungary) aged 25 years and older, with a population of 8866 people, 70.5% of whom are women. The study builds on the successful experiences of the Whitehall II study and aims to investigate the complex relationships between lifestyle, environmental, and occupational risk factors, and the development and progression of chronic age-associated diseases. An important goal of the Semmelweis Study is to identify groups of people who are aging unsuccessfully and therefore have an increased risk of developing age-associated diseases. To achieve this, the study takes a multidisciplinary approach, collecting economic, social, psychological, cognitive, health, and biological data. The Semmelweis Study comprises a baseline data collection with open healthcare data linkage, followed by repeated data collection waves every 5 years. Data are collected through computer-assisted self-completed questionnaires, followed by a physical health examination, physiological measurements, and the assessment of biomarkers. This article provides a comprehensive overview of the Semmelweis Study, including its origin, context, objectives, design, relevance, and expected contributions.
Tárgyszavak:
Orvostudományok
Egészségtudományok
idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Age-associated diseases
Biological age
Central Europe
Epidemiology
Health Promoting University
Healthy aging
Workplace cohort
Megjelenés:
GeroScience. - 46 : 1 (2024), p. 191-218. -
További szerzők:
Tabák Ádám G.
Ádány Róza (1952-) (megelőző orvostan és népegészségtan szakorvos)
Purebl György
Kaposvári Csilla
Fazekas-Pongor Vince
Csípő Tamás (1990-)
Szarvas Zsófia
Horváth Krisztián
Mukli Péter
Balog Róbert
Bódizs Róbert
Ujma Péter
Stauder Adrienne
Belsky, Daniel W.
Kovács Illés
Yabluchanskiy, Andriy
Maier, Andrea B.
Moizs Marianna (1964-) (orvos)
Östlin Piroska
Yon, Yongjie
Varga Péter
Vokó Zoltán (1968-) (epidemiológus)
Papp Magor Csongor (1978-) (háziorvostan szakorvos)
Takács István
Vásárhelyi Barna
Torzsa Péter
Ferdinándy Péter
Csiszár Anna
Benyó Zoltán
Szabó Attila (gyermekgyógyász Budapest)
Dörnyei Gabriella
Kivimäki, Mika
Kellermayer Miklós
Merkely Béla (1965-) (orvos)
Internet cím:
Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
Borító:
Saját polcon:
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