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001-es BibID:BIBFORM099943
035-os BibID:(WOS)000469877700003 (Scopus)85066471327
Első szerző:Csípő Tamás
Cím:Age-related decline in peripheral vascular health predicts cognitive impairment / Csipo Tamas, Lipecz Agnes, Fulop Gabor A., Hand Rachel A., Ngo Bich-Thy N., Dzialendzik Mikita, Tarantini Stefano, Balasubramanian Priya, Kiss Tamas, Yabluchanska Valeriya, Silva-Palacios Federico, Courtney Donald L., Dasari Tarun W., Sorond Farzaneh, Sonntag William E., Csiszar Anna, Ungvari Zoltan, Yabluchanskiy Andriy
Dátum:2019
ISSN:2509-2715 2509-2723
Megjegyzések:Preclinical studies demonstrate that generalized endothelial cell dysfunction and microvascular impairment are potentially reversible causes of age-related vascular cognitive impairment and dementia (VCID). The present study was designed to test the hypothesis that severity of age-related macro- and microvascular dysfunction measured in the peripheral circulation is an independent predictor of cognitive performance in older adults. In this study, we enrolled 63 healthy individuals into young (< 45 years old) and aged (> 65 years old) groups. We used principal component analysis (PCA) to construct a comprehensive peripheral vascular health index (VHI) encompassing peripheral microvascular reactivity, arterial endothelial function, and vascular stiffness, as a marker of aging-induced generalized vascular dysfunction. Peripheral macrovascular and microvascular endothelial function were assessed using flow-mediated dilation (FMD) and laser speckle contrast imaging tests. Pulse waveform analysis was used to evaluate the augmentation index (AIx), a measure of arterial stiffness. Cognitive function was measured using a panel of CANTAB cognitive tests, and PCA was then applied to generate a cognitive impairment index (CII) for each participant. Aged subjects exhibited significantly impaired macrovascular endothelial function (FMD, 5.6 ? 0.7% vs. 8.3 ? 0.6% in young, p = 0.0061), increased arterial stiffness (AIx 29.3 ? 1.8% vs 4.5 ? 2.6% in young, p < 0.0001), and microvascular dysfunction (2.8 ? 0.2 vs 3.4 ? 0.1-fold change of perfusion in young, p = 0.032). VHI showed a significant negative correlation with age (r = - 0.54, p < 0.0001) and CII significantly correlated with age (r = 0.79, p < 0.0001). VHI significantly correlated with the CII (r = - 0.46, p = 0.0003). A decline in peripheral vascular health may reflect generalized vascular dysfunction and predict cognitive impairment in older adults.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Aging
Endothelial function
Cognitive impairment
Microvascular dysfunction
VCID
Megjelenés:GeroScience. - 41 : 2 (2019), p. 125-136. -
További szerzők:Lipécz Ágnes Fülöp Gábor Áron (1988-) (általános orvos) Hand, Rachel A. Ngo, Bich-Thy N. Dzialendzik, Mikita Tarantini, Stefano Balasubramanian, Priya Kiss Tamás (1950-) (vegyész) Yabluchanska, Valeriya Silva-Palacios, Federico Courtney, Donald L. Dasari, Tarun W. Sorond, Farzaneh A. Sonntag, William E. Csiszár Anna Ungvári Zoltán Yabluchanskiy, Andriy
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2.

001-es BibID:BIBFORM099924
035-os BibID:(cikkazonosító)20994 (WOS)000711121600052 (Scopus)85108282219
Első szerző:Csípő Tamás
Cím:Sleep deprivation impairs cognitive performance, alters task-associated cerebral blood flow and decreases cortical neurovascular coupling-related hemodynamic responses / Csipo Tamas, Lipecz Agnes, Owens Cameron, Mukli Peter, Perry Jonathan W., Tarantini Stefano, Balasubramanian Priya, Nyúl-Tóth Ádám, Yabluchanska Valeriya, Sorond Farzaneh A., Kellawan J. Mikhail, Purebl György, Sonntag William E., Csiszar Anna, Ungvari Zoltan, Yabluchanskiy Andriy
Dátum:2021
ISSN:2045-2322
Megjegyzések:Sleep deprivation (SD) is a common condition and an important health concern. In addition to metabolic and cardiovascular risks, SD associates with decreases in cognitive performance. Neurovascular coupling (NVC, "functional hyperemia") is a critical homeostatic mechanism, which maintains adequate blood supply to the brain during periods of intensive neuronal activity. To determine whether SD alters NVC responses and cognitive performance, cognitive and hemodynamic NVC assessments were conducted prior to and 24 h post-SD in healthy young male individuals (n?=?10, 27???3 years old). Cognition was evaluated with a battery of tests from the Cambridge Neuropsychological Test Automated Battery (CANTAB). Hemodynamic components of NVC were measured by transcranial Doppler sonography (TCD) during cognitive stimulation, dynamic retinal vessel analysis (DVA) during flicker light stimulation, and functional near infrared spectroscopy (fNIRS) during finger tapping motor task. Cognitive assessments revealed impairments in reaction time and sustained attention after 24 h of SD. Functional NIRS analysis revealed that SD significantly altered hemodynamic responses in the prefrontal cortex and somatosensory cortex during a motor task. NVC-related vascular responses measured by DVA and TCD did not change significantly. Interestingly, TCD detected decreased task-associated cerebral blood flow (CBF) in the right middle cerebral artery in sleep deprived participants. Our results demonstrate that 24 h of SD lead to impairments in cognitive performance together with altered CBF and hemodynamic components of cortical NVC responses.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Cognitive neuroscience
Neurological disorders
Translational research
Megjelenés:Scientific Reports. - 11 : 1 (2021), p. 1-13. -
További szerzők:Lipécz Ágnes Owens, Cameron D. Mukli Péter Perry, Jonathan W. Tarantini, Stefano Balasubramanian, Priya Nyúl-Tóth Ádám Yabluchanska, Valeriya Sorond, Farzaneh A. Kellawan, J. Mikhail Purebl György Sonntag, William E. Csiszár Anna Ungvári Zoltán Yabluchanskiy, Andriy
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3.

001-es BibID:BIBFORM117772
035-os BibID:(cikkazonosító)2303516 (Scopus)85180713903 (WoS)001133874100001
Első szerző:Mukli Péter
Cím:Impaired Neurovascular Coupling and Increased Functional Connectivity in the Frontal Cortex Predict Age-Related Cognitive Dysfunction / Mukli Peter, Pinto Camila B., Owens Cameron D., Csipo Tamas, Lipecz Agnes, Szarvas Zsofia, Peterfi Anna, Langley Ana Clara da Costa Pinaffi, Hoffmeister Jordan, Racz Frigyes Samuel, Perry Jonathan W., Tarantini Stefano, Nyúl-Tóth Ádám, Sorond Farzaneh A., Yang Yuan, James Judith A., Kirkpatrick Angelia C., Prodan Calin I., Toth Peter, Galindo Juliette, Gardner Andrew W., Sonntag William E., Csiszar Anna, Ungvari Zoltan, Yabluchanskiy Andriy
Dátum:2023
ISSN:2198-3844
Megjegyzések:Impaired cerebrovascular function contributes to the genesis of age-related cognitive decline. In this study, the hypothesis is tested that impairments in neurovascular coupling (NVC) responses and brain network function predict cognitive dysfunction in older adults. Cerebromicrovascular and working memory function of healthy young (n = 21, 33.2?7.0 years) and aged (n = 30, 75.9?6.9 years) participants are assessed. To determine NVC responses and functional connectivity (FC) during a working memory (n-back) paradigm, oxy- and deoxyhemoglobin concentration changes from the frontal cortex using functional near-infrared spectroscopy are recorded. NVC responses are significantly impaired during the 2-back task in aged participants, while the frontal networks are characterized by higher local and global connection strength, and dynamic FC (p < 0.05). Both impaired NVC and increased FC correlate with age-related decline in accuracy during the 2-back task. These findings suggest that task-related brain states in older adults require stronger functional connections to compensate for the attenuated NVC responses associated with working memory load. ? 2023 The Authors. Advanced Science published by Wiley-VCH GmbH.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
aging
cognitive decline
functional connectivity
functional near-infrared spectroscopy
neurovascular coupling
Megjelenés:Advanced Science. - 2023 (2023), p. 1-18. -
További szerzők:Pinto, Camila B. Owens, Cameron D. Csípő Tamás (1990-) Lipécz Ágnes Szarvas Zsófia Péterfi Anna Langley, Ana Clara da Costa Pinaffi Hoffmeister, Jordan Rácz Frigyes Sámuel Perry, Jonathan W. Tarantini, Stefano Nyúl-Tóth Ádám Sorond, Farzaneh A. Yang, Yuan James, Judith A. Kirkpatrick, Angelia C. Prodan, Calin I. Tóth Péter Galindo, Juliette Gardner, Andrew W. Sonntag, William E. Csiszár Anna Ungvári Zoltán Yabluchanskiy, Andriy
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4.

001-es BibID:BIBFORM099921
035-os BibID:(cikkazonosító)e02135
Első szerző:Mukli Péter
Cím:Sleep deprivation alters task-related changes in functional connectivity of the frontal cortex : a near-infrared spectroscopy study / Mukli Peter, Csipo Tamas, Lipecz Agnes, Stylianou Orestis, Racz Frigyes Samuel, Owens Cameron D., Perry Jonathan W., Tarantini Stefano, Sorond Farzaneh A., Kellawan Jeremy M., Purebl György, Yang Yuan, Sonntag William E., Csiszar Anna, Ungvari Zoltan I., Yabluchanskiy Andriy
Dátum:2021
ISSN:2162-3279
Megjegyzések:Sleep deprivation (SD) is known to be associated with decreased cognitive performance; however, the underlying mechanisms are poorly understood. As interactions between distinct brain regions depend on mental state, functional brain networks established by these connections typically show a reorganization during task. Hence, analysis of functional connectivity (FC) could reveal the task-related change in the examined frontal brain networks. Our objective was to assess the impact of SD on static FC in the prefrontal and motor cortices and find whether changes in FC correlate with changes in neuropsychological scores. Healthy young male individuals (n = 10, 27.6 ? 3.7 years of age) participated in the study. A battery of tests from the Cambridge Neuropsychological Test Automated Battery (CANTAB) and 48 channel functional near-infrared spectroscopy (fNIRS) measurements were performed before and after 24 hr of SD. Network metrics were obtained by graph theoretical analysis using the fNIRS records in resting state and during finger-tapping sessions. During task, SD resulted in a significantly smaller decrease in the number and strength of functional connections (characterizing FC) in the frontal cortex. Changes in the global connection strengths correlated with decreased performance in the paired association learning test. These results indicate a global impact of SD on functional brain networks in the frontal lobes.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
functional connectivity
near-infrared
neuropsychological tests
sleep deprivation
spectroscopy
Megjelenés:Brain and Behavior. - 11 : 8 (2021), p. 1-14. -
További szerzők:Csípő Tamás (1990-) Lipécz Ágnes Stylianou, Orestis Rácz Frigyes Sámuel Owens, Cameron D. Perry, Jonathan W. Tarantini, Stefano Sorond, Farzaneh A. Kellawan, Jeremy M. Purebl György Yang, Yuan Sonntag, William E. Csiszár Anna Ungvári Zoltán Yabluchanskiy, Andriy
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5.

001-es BibID:BIBFORM099928
035-os BibID:(WOS)000516499100001 (Scopus)85078289607
Első szerző:Yabluchanskiy, Andriy
Cím:Pharmacological or genetic depletion of senescent astrocytes prevents whole brain irradiation-induced impairment of neurovascular coupling responses protecting cognitive function in mice / Yabluchanskiy Andriy, Tarantini Stefano, Balasubramanian Priya, Kiss Tamas, Csipo Tamas, Fülöp Gábor A., Lipecz Agnes, Ahire Chetan, DelFavero Jordan, Nyul-Toth Adam, Sonntag William E., Schwartzman Michal L., Campisi Judith, Csiszar Anna, Ungvari Zoltan
Dátum:2020
ISSN:2509-2715 2509-2723
Megjegyzések:Whole brain irradiation (WBI, also known as whole brain radiation therapy or WBRT) is a mainstream therapy for patients with identifiable brain metastases and as a prophylaxis for microscopic malignancies. WBI accelerates brain aging, causing progressive cognitive dysfunction in ~ 50% of surviving patients, thus compromising quality of life. The mechanisms responsible for this WBI side effect remain obscure, and there are no effective treatments or prevention strategies. Here, we test the hypothesis that WBI induces astrocyte senescence, which contributes to impaired astrocytic neurovascular coupling (NVC) responses and the genesis of cognitive decline. To achieve this goal, we used transgenic p16-3MR mice, which allows the detection and selective elimination of senescent cells. We subjected these mice to a clinically relevant protocol of fractionated WBI (5 Gy twice weekly for 4 weeks). WBI-treated and control mice were tested for spatial memory performance (radial arm water maze), astrocyte-dependent NVC responses (whisker-stimulation-induced increases in cerebral blood flow, assessed by laser speckle contrast imaging), NVC-related gene expression, astrocytic release of eicosanoid gliotransmitters and the presence of senescent astrocytes (by flow cytometry, immunohistochemistry and gene expression profiling) at 6 months post-irradiation. WBI induced senescence in astrocytes, which associated with NVC dysfunction and impaired performance on cognitive tasks. To establish a causal relationship between WBI-induced senescence and NVC dysfunction, senescent cells were depleted from WBI-treated animals (at 3 months post-WBI) by genetic (ganciclovir treatment) or pharmacological (treatment with the BCL-2/BCL-xL inhibitor ABT263/Navitoclax, a known senolytic drug) means. In WBI-treated mice, both treatments effectively eliminated senescent astrocytes, rescued NVC responses, and improved cognitive performance. Our findings suggest that the use of senolytic drugs can be a promising strategy for preventing the cognitive impairment associated with WBI.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Aging
Dementia
Functional hyperemia
Radiation
Senescence
Vascular cognitive impairment
WBI
WBRT
Whole brain radiation therapy
Megjelenés:GeroScience. - 42 : 2 (2020), p. 409-428. -
További szerzők:Tarantini, Stefano Balasubramanian, Priya Kiss Tamás (1950-) (vegyész) Csípő Tamás (1990-) Fülöp Gábor Áron (1988-) (általános orvos) Lipécz Ágnes Ahire, Chetan DelFavero, Jordan Nyúl-Tóth Ádám Sonntag, William E. Schwartzman, Michal L. Campisi, Judith Csiszár Anna Ungvári Zoltán
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