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001-es BibID:BIBFORM099947
035-os BibID:(WOS)000493706100001 (Scopus)85074834329
Első szerző:Csípő Tamás
Cím:Assessment of age-related decline of neurovascular coupling responses by functional near-infrared spectroscopy (fNIRS) in humans / Csipo Tamas, Mukli Peter, Lipecz Agnes, Tarantini Stefano, Bahadli Dhay, Abdulhussein Osamah, Owens Cameron, Kiss Tamas, Balasubramanian Priya, Nyúl-Tóth Ádám, Hand Rachel A., Yabluchanska Valeriya, Sorond Farzaneh A., Csiszar Anna, Ungvari Zoltan, Yabluchanskiy Andriy
Dátum:2019
ISSN:2509-2715 2509-2723
Megjegyzések:Preclinical studies provide strong evidence that age-related impairment of neurovascular coupling (NVC) plays a causal role in the pathogenesis of vascular cognitive impairment (VCI). NVC is a critical homeostatic mechanism in the brain, responsible for adjustment of local cerebral blood flow to the energetic needs of the active neuronal tissue. Recent progress in geroscience has led to the identification of critical cellular and molecular mechanisms involved in neurovascular aging, identifying these pathways as targets for intervention. In order to translate the preclinical findings to humans, there is a need to assess NVC in geriatric patients as an endpoint in clinical studies. Functional near-infrared spectroscopy (fNIRS) is a non-invasive neuroimaging technique that enables the investigation of local changes in cerebral blood flow, quantifying task-related changes in oxygenated and deoxygenated hemoglobin concentrations. In the present overview, the basic principles of fNIRS are introduced and the application of this technique to assess NVC in older adults with implications for the design of studies on the mechanistic underpinnings of VCI is discussed.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Aging
Cognitive aging
Functional near-infrared spectroscopy
Neurovascular coupling
VCI
VCID
Vascular cognitive impairment and dementia
fNIRS
Megjelenés:GeroScience. - 41 : 5 (2019), p. 495-509. -
További szerzők:Mukli Péter Lipécz Ágnes Tarantini, Stefano Bahadli, Dhay Abdulhussein, Osamah Owens, Cameron D. Kiss Tamás (1950-) (vegyész) Balasubramanian, Priya Nyúl-Tóth Ádám Hand, Rachel A. Yabluchanska, Valeriya Sorond, Farzaneh A. Csiszár Anna Ungvári Zoltán Yabluchanskiy, Andriy
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2.

001-es BibID:BIBFORM099943
035-os BibID:(WOS)000469877700003 (Scopus)85066471327
Első szerző:Csípő Tamás
Cím:Age-related decline in peripheral vascular health predicts cognitive impairment / Csipo Tamas, Lipecz Agnes, Fulop Gabor A., Hand Rachel A., Ngo Bich-Thy N., Dzialendzik Mikita, Tarantini Stefano, Balasubramanian Priya, Kiss Tamas, Yabluchanska Valeriya, Silva-Palacios Federico, Courtney Donald L., Dasari Tarun W., Sorond Farzaneh, Sonntag William E., Csiszar Anna, Ungvari Zoltan, Yabluchanskiy Andriy
Dátum:2019
ISSN:2509-2715 2509-2723
Megjegyzések:Preclinical studies demonstrate that generalized endothelial cell dysfunction and microvascular impairment are potentially reversible causes of age-related vascular cognitive impairment and dementia (VCID). The present study was designed to test the hypothesis that severity of age-related macro- and microvascular dysfunction measured in the peripheral circulation is an independent predictor of cognitive performance in older adults. In this study, we enrolled 63 healthy individuals into young (< 45 years old) and aged (> 65 years old) groups. We used principal component analysis (PCA) to construct a comprehensive peripheral vascular health index (VHI) encompassing peripheral microvascular reactivity, arterial endothelial function, and vascular stiffness, as a marker of aging-induced generalized vascular dysfunction. Peripheral macrovascular and microvascular endothelial function were assessed using flow-mediated dilation (FMD) and laser speckle contrast imaging tests. Pulse waveform analysis was used to evaluate the augmentation index (AIx), a measure of arterial stiffness. Cognitive function was measured using a panel of CANTAB cognitive tests, and PCA was then applied to generate a cognitive impairment index (CII) for each participant. Aged subjects exhibited significantly impaired macrovascular endothelial function (FMD, 5.6 ? 0.7% vs. 8.3 ? 0.6% in young, p = 0.0061), increased arterial stiffness (AIx 29.3 ? 1.8% vs 4.5 ? 2.6% in young, p < 0.0001), and microvascular dysfunction (2.8 ? 0.2 vs 3.4 ? 0.1-fold change of perfusion in young, p = 0.032). VHI showed a significant negative correlation with age (r = - 0.54, p < 0.0001) and CII significantly correlated with age (r = 0.79, p < 0.0001). VHI significantly correlated with the CII (r = - 0.46, p = 0.0003). A decline in peripheral vascular health may reflect generalized vascular dysfunction and predict cognitive impairment in older adults.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Aging
Endothelial function
Cognitive impairment
Microvascular dysfunction
VCID
Megjelenés:GeroScience. - 41 : 2 (2019), p. 125-136. -
További szerzők:Lipécz Ágnes Fülöp Gábor Áron (1988-) (általános orvos) Hand, Rachel A. Ngo, Bich-Thy N. Dzialendzik, Mikita Tarantini, Stefano Balasubramanian, Priya Kiss Tamás (1950-) (vegyész) Yabluchanska, Valeriya Silva-Palacios, Federico Courtney, Donald L. Dasari, Tarun W. Sorond, Farzaneh A. Sonntag, William E. Csiszár Anna Ungvári Zoltán Yabluchanskiy, Andriy
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Intézményi repozitóriumban (DEA) tárolt változat
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3.

001-es BibID:BIBFORM099924
035-os BibID:(cikkazonosító)20994 (WOS)000711121600052 (Scopus)85108282219
Első szerző:Csípő Tamás
Cím:Sleep deprivation impairs cognitive performance, alters task-associated cerebral blood flow and decreases cortical neurovascular coupling-related hemodynamic responses / Csipo Tamas, Lipecz Agnes, Owens Cameron, Mukli Peter, Perry Jonathan W., Tarantini Stefano, Balasubramanian Priya, Nyúl-Tóth Ádám, Yabluchanska Valeriya, Sorond Farzaneh A., Kellawan J. Mikhail, Purebl György, Sonntag William E., Csiszar Anna, Ungvari Zoltan, Yabluchanskiy Andriy
Dátum:2021
ISSN:2045-2322
Megjegyzések:Sleep deprivation (SD) is a common condition and an important health concern. In addition to metabolic and cardiovascular risks, SD associates with decreases in cognitive performance. Neurovascular coupling (NVC, "functional hyperemia") is a critical homeostatic mechanism, which maintains adequate blood supply to the brain during periods of intensive neuronal activity. To determine whether SD alters NVC responses and cognitive performance, cognitive and hemodynamic NVC assessments were conducted prior to and 24 h post-SD in healthy young male individuals (n?=?10, 27???3 years old). Cognition was evaluated with a battery of tests from the Cambridge Neuropsychological Test Automated Battery (CANTAB). Hemodynamic components of NVC were measured by transcranial Doppler sonography (TCD) during cognitive stimulation, dynamic retinal vessel analysis (DVA) during flicker light stimulation, and functional near infrared spectroscopy (fNIRS) during finger tapping motor task. Cognitive assessments revealed impairments in reaction time and sustained attention after 24 h of SD. Functional NIRS analysis revealed that SD significantly altered hemodynamic responses in the prefrontal cortex and somatosensory cortex during a motor task. NVC-related vascular responses measured by DVA and TCD did not change significantly. Interestingly, TCD detected decreased task-associated cerebral blood flow (CBF) in the right middle cerebral artery in sleep deprived participants. Our results demonstrate that 24 h of SD lead to impairments in cognitive performance together with altered CBF and hemodynamic components of cortical NVC responses.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Cognitive neuroscience
Neurological disorders
Translational research
Megjelenés:Scientific Reports. - 11 : 1 (2021), p. 1-13. -
További szerzők:Lipécz Ágnes Owens, Cameron D. Mukli Péter Perry, Jonathan W. Tarantini, Stefano Balasubramanian, Priya Nyúl-Tóth Ádám Yabluchanska, Valeriya Sorond, Farzaneh A. Kellawan, J. Mikhail Purebl György Sonntag, William E. Csiszár Anna Ungvári Zoltán Yabluchanskiy, Andriy
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Intézményi repozitóriumban (DEA) tárolt változat
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4.

001-es BibID:BIBFORM108985
035-os BibID:(scopus)85065594719 (wos)000467562000011
Első szerző:Fülöp Gábor Áron (általános orvos)
Cím:Role of age-related alterations of the cerebral venous circulation in the pathogenesis of vascular cognitive impairment / Fulop Gabor A., Tarantini Stefano, Yabluchanskiy Andriy, Molnar Andrea, Prodan Calin I., Kiss Tamas, Csipo Tamas, Lipecz Agnes, Balasubramanian Priya, Farkas Eszter, Toth Peter, Sorond Farzaneh, Csiszar Anna, Ungvari Zoltan
Dátum:2019
ISSN:0363-6135
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:American Journal Of Physiology-Heart And Circulatory Physiology. - 316 : 5 (2019), p. H1124-H1140. -
További szerzők:Tarantini, Stefano Yabluchanskiy, Andriy Molnár Andrea (Budapest) Prodan, Calin I. Kiss Tamás Csípő Tamás (1990-) Lipécz Ágnes Balasubramanian, Priya Farkas Eszter Tóth Péter Sorond, Farzaneh A. Csiszár Anna Ungvári Zoltán
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Intézményi repozitóriumban (DEA) tárolt változat
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5.

001-es BibID:BIBFORM099921
035-os BibID:(cikkazonosító)e02135
Első szerző:Mukli Péter
Cím:Sleep deprivation alters task-related changes in functional connectivity of the frontal cortex : a near-infrared spectroscopy study / Mukli Peter, Csipo Tamas, Lipecz Agnes, Stylianou Orestis, Racz Frigyes Samuel, Owens Cameron D., Perry Jonathan W., Tarantini Stefano, Sorond Farzaneh A., Kellawan Jeremy M., Purebl György, Yang Yuan, Sonntag William E., Csiszar Anna, Ungvari Zoltan I., Yabluchanskiy Andriy
Dátum:2021
ISSN:2162-3279
Megjegyzések:Sleep deprivation (SD) is known to be associated with decreased cognitive performance; however, the underlying mechanisms are poorly understood. As interactions between distinct brain regions depend on mental state, functional brain networks established by these connections typically show a reorganization during task. Hence, analysis of functional connectivity (FC) could reveal the task-related change in the examined frontal brain networks. Our objective was to assess the impact of SD on static FC in the prefrontal and motor cortices and find whether changes in FC correlate with changes in neuropsychological scores. Healthy young male individuals (n = 10, 27.6 ? 3.7 years of age) participated in the study. A battery of tests from the Cambridge Neuropsychological Test Automated Battery (CANTAB) and 48 channel functional near-infrared spectroscopy (fNIRS) measurements were performed before and after 24 hr of SD. Network metrics were obtained by graph theoretical analysis using the fNIRS records in resting state and during finger-tapping sessions. During task, SD resulted in a significantly smaller decrease in the number and strength of functional connections (characterizing FC) in the frontal cortex. Changes in the global connection strengths correlated with decreased performance in the paired association learning test. These results indicate a global impact of SD on functional brain networks in the frontal lobes.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
functional connectivity
near-infrared
neuropsychological tests
sleep deprivation
spectroscopy
Megjelenés:Brain and Behavior. - 11 : 8 (2021), p. 1-14. -
További szerzők:Csípő Tamás (1990-) Lipécz Ágnes Stylianou, Orestis Rácz Frigyes Sámuel Owens, Cameron D. Perry, Jonathan W. Tarantini, Stefano Sorond, Farzaneh A. Kellawan, Jeremy M. Purebl György Yang, Yuan Sonntag, William E. Csiszár Anna Ungvári Zoltán Yabluchanskiy, Andriy
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Intézményi repozitóriumban (DEA) tárolt változat
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