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001-es BibID:	BIBFORM099948
035-os BibID:	(WOS)000500795500001 (Scopus)85075945416
Első szerző:	Lipécz Ágnes
Cím:	Microvascular contributions to age-related macular degeneration (AMD) : from mechanisms of choriocapillaris aging to novel interventions / Lipecz Agnes, Miller Lauren, Kovacs Illes, Czakó Cecília, Csipo Tamas, Baffi Judit, Csiszar Anna, Tarantini Stefano, Ungvari Zoltan, Yabluchanskiy Andriy, Conley Shannon
Dátum:	2019
ISSN:	2509-2715 2509-2723
Megjegyzések:	Aging of the microcirculatory network plays a central role in the pathogenesis of a wide range of age-related diseases, from heart failure to Alzheimer's disease. In the eye, changes in the choroid and choroidal microcirculation (choriocapillaris) also occur with age, and these changes can play a critical role in the pathogenesis of age-related macular degeneration (AMD). In order to develop novel treatments for amelioration of choriocapillaris aging and prevention of AMD, it is essential to understand the cellular and functional changes that occur in the choroid and choriocapillaris during aging. In this review, recent advances in in vivo analysis of choroidal structure and function in AMD patients and patients at risk for AMD are discussed. The pathophysiological roles of fundamental cellular and molecular mechanisms of aging including oxidative stress, mitochondrial dysfunction, and impaired resistance to molecular stressors in the choriocapillaris are also considered in terms of their contribution to the pathogenesis of AMD. The pathogenic roles of cardiovascular risk factors that exacerbate microvascular aging processes, such as smoking, hypertension, and obesity as they relate to AMD and choroid and choriocapillaris changes in patients with these cardiovascular risk factors, are also discussed. Finally, future directions and opportunities to develop novel interventions to prevent/delay AMD by targeting fundamental cellular and molecular aging processes are presented.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk Cardiovascular risk factors Choroidal thickness Hypertension OCTA Retina SD-OCT Smoking
Megjelenés:	GeroScience. - 41 : 6 (2019), p. 813-845. -
További szerzők:	Miller, Lauren Kovács Illés Czakó Cecília Csípő Tamás (1990-) Baffi Judit Csiszár Anna Tarantini, Stefano Ungvári Zoltán Yabluchanskiy, Andriy Conley, Shannon M.
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM099944
035-os BibID:	(WOS)000481790700008 (Scopus)85070755106
Első szerző:	Lipécz Ágnes
Cím:	Age-related impairment of neurovascular coupling responses : a dynamic vessel analysis (DVA)-based approach to measure decreased flicker light stimulus-induced retinal arteriolar dilation in healthy older adults / Lipecz Agnes, Csipo Tamas, Tarantini Stefano, Hand Rachel A., Ngo Bich-Thy N., Conley Shannon, Nemeth Gabor, Tsorbatzoglou Alexis, Courtney Donald L., Yabluchanska Valeriya, Csiszar Anna, Ungvari Zoltan I., Yabluchanskiy Andriy
Dátum:	2019
ISSN:	2509-2715 2509-2723
Megjegyzések:	Aging is a major risk factor for vascular cognitive impairment and dementia (VCID). Recent studies demonstrate that cerebromicrovascular dysfunction plays a causal role in the development of age-related cognitive impairment, in part via disruption of neurovascular coupling (NVC) responses. NVC (functional hyperemia) is responsible for adjusting cerebral blood flow to the increased energetic demands of activated neurons, and in preclinical animal models of aging, pharmacological restoration of NVC is associated with improved cognitive performance. To translate these findings, there is an increasing need to develop novel and sensitive tools to assess cerebromicrovascular function and NVC to assess risk for VCID and evaluate treatment efficacy. Due to shared developmental origins, anatomical features, and physiology, assessment of retinal vessel function may serve as an important surrogate outcome measure to study neurovascular dysfunction. The present study was designed to compare NVC responses in young (< 45 years of age; n = 18) and aged (> 65 years of age; n = 11) healthy human subjects by assessing flicker light-induced changes in the diameter of retinal arterioles using a dynamic vessel analyzer (DVA)-based approach. We found that NVC responses in retinal arterioles were significantly decreased in older adults as compared with younger subjects. We propose that the DVA-based approach can be used to assess NVC, as a surrogate cerebromicrovascular outcome measure, to evaluate the effects of therapeutic interventions in older individuals.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk Aging Dynamic retinal vessel analysis Endothelial dysfunction Neurovascular coupling Vascular cognitive impairment and dementia
Megjelenés:	GeroScience. - 41 : 3 (2019), p. 341-349. -
További szerzők:	Csípő Tamás (1990-) Tarantini, Stefano Hand, Rachel A. Ngo, Bich-Thy N. Conley, Shannon M. Németh Gábor (1975-) (szemész) Tsorbatzoglou, Alexis (1970-) (szemész) Courtney, Donald L. Yabluchanska, Valeriya Csiszár Anna Ungvári Zoltán Yabluchanskiy, Andriy
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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