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001-es BibID:	BIBFORM099924
035-os BibID:	(cikkazonosító)20994 (WOS)000711121600052 (Scopus)85108282219
Első szerző:	Csípő Tamás
Cím:	Sleep deprivation impairs cognitive performance, alters task-associated cerebral blood flow and decreases cortical neurovascular coupling-related hemodynamic responses / Csipo Tamas, Lipecz Agnes, Owens Cameron, Mukli Peter, Perry Jonathan W., Tarantini Stefano, Balasubramanian Priya, Nyúl-Tóth Ádám, Yabluchanska Valeriya, Sorond Farzaneh A., Kellawan J. Mikhail, Purebl György, Sonntag William E., Csiszar Anna, Ungvari Zoltan, Yabluchanskiy Andriy
Dátum:	2021
ISSN:	2045-2322
Megjegyzések:	Sleep deprivation (SD) is a common condition and an important health concern. In addition to metabolic and cardiovascular risks, SD associates with decreases in cognitive performance. Neurovascular coupling (NVC, "functional hyperemia") is a critical homeostatic mechanism, which maintains adequate blood supply to the brain during periods of intensive neuronal activity. To determine whether SD alters NVC responses and cognitive performance, cognitive and hemodynamic NVC assessments were conducted prior to and 24 h post-SD in healthy young male individuals (n?=?10, 27???3 years old). Cognition was evaluated with a battery of tests from the Cambridge Neuropsychological Test Automated Battery (CANTAB). Hemodynamic components of NVC were measured by transcranial Doppler sonography (TCD) during cognitive stimulation, dynamic retinal vessel analysis (DVA) during flicker light stimulation, and functional near infrared spectroscopy (fNIRS) during finger tapping motor task. Cognitive assessments revealed impairments in reaction time and sustained attention after 24 h of SD. Functional NIRS analysis revealed that SD significantly altered hemodynamic responses in the prefrontal cortex and somatosensory cortex during a motor task. NVC-related vascular responses measured by DVA and TCD did not change significantly. Interestingly, TCD detected decreased task-associated cerebral blood flow (CBF) in the right middle cerebral artery in sleep deprived participants. Our results demonstrate that 24 h of SD lead to impairments in cognitive performance together with altered CBF and hemodynamic components of cortical NVC responses.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk Cognitive neuroscience Neurological disorders Translational research
Megjelenés:	Scientific Reports. - 11 : 1 (2021), p. 1-13. -
További szerzők:	Lipécz Ágnes Owens, Cameron D. Mukli Péter Perry, Jonathan W. Tarantini, Stefano Balasubramanian, Priya Nyúl-Tóth Ádám Yabluchanska, Valeriya Sorond, Farzaneh A. Kellawan, J. Mikhail Purebl György Sonntag, William E. Csiszár Anna Ungvári Zoltán Yabluchanskiy, Andriy
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001-es BibID:	BIBFORM099921
035-os BibID:	(cikkazonosító)e02135
Első szerző:	Mukli Péter
Cím:	Sleep deprivation alters task-related changes in functional connectivity of the frontal cortex : a near-infrared spectroscopy study / Mukli Peter, Csipo Tamas, Lipecz Agnes, Stylianou Orestis, Racz Frigyes Samuel, Owens Cameron D., Perry Jonathan W., Tarantini Stefano, Sorond Farzaneh A., Kellawan Jeremy M., Purebl György, Yang Yuan, Sonntag William E., Csiszar Anna, Ungvari Zoltan I., Yabluchanskiy Andriy
Dátum:	2021
ISSN:	2162-3279
Megjegyzések:	Sleep deprivation (SD) is known to be associated with decreased cognitive performance; however, the underlying mechanisms are poorly understood. As interactions between distinct brain regions depend on mental state, functional brain networks established by these connections typically show a reorganization during task. Hence, analysis of functional connectivity (FC) could reveal the task-related change in the examined frontal brain networks. Our objective was to assess the impact of SD on static FC in the prefrontal and motor cortices and find whether changes in FC correlate with changes in neuropsychological scores. Healthy young male individuals (n = 10, 27.6 ? 3.7 years of age) participated in the study. A battery of tests from the Cambridge Neuropsychological Test Automated Battery (CANTAB) and 48 channel functional near-infrared spectroscopy (fNIRS) measurements were performed before and after 24 hr of SD. Network metrics were obtained by graph theoretical analysis using the fNIRS records in resting state and during finger-tapping sessions. During task, SD resulted in a significantly smaller decrease in the number and strength of functional connections (characterizing FC) in the frontal cortex. Changes in the global connection strengths correlated with decreased performance in the paired association learning test. These results indicate a global impact of SD on functional brain networks in the frontal lobes.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk functional connectivity near-infrared neuropsychological tests sleep deprivation spectroscopy
Megjelenés:	Brain and Behavior. - 11 : 8 (2021), p. 1-14. -
További szerzők:	Csípő Tamás (1990-) Lipécz Ágnes Stylianou, Orestis Rácz Frigyes Sámuel Owens, Cameron D. Perry, Jonathan W. Tarantini, Stefano Sorond, Farzaneh A. Kellawan, Jeremy M. Purebl György Yang, Yuan Sonntag, William E. Csiszár Anna Ungvári Zoltán Yabluchanskiy, Andriy
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001-es BibID:	BIBFORM117425
035-os BibID:	(Scopus)85179338215 (WoS)001115572500001
Első szerző:	Ungvári Zoltán
Cím:	The Semmelweis Study : a longitudinal occupational cohort study within the framework of the Semmelweis Caring University Model Program for supporting healthy aging / Zoltan Ungvari, Adam G. Tabák, Roza Adany, György Purebl, Csilla Kaposvári, Vince Fazekas-Pongor, Tamás Csípő, Zsófa Szarvas, Krisztián Horváth, Peter Mukli, Piroska Balog, Robert Bodizs, Peter Ujma, Adrienne Stauder, Daniel W. Belsky, Illés Kovács, Andriy Yabluchanskiy, Andrea B. Maier, Mariann Moizs, Piroska Östlin, Yongjie Yon, Péter Varga, Zoltán Vokó, Magor Papp, István Takács, Barna Vásárhelyi, Péter Torzsa, Péter Ferdinandy, Anna Csiszar, Zoltán Benyó, Attila J. Szabó, Gabriella Dörnyei, Mika Kivimäki, Miklos Kellermayer, Bela Merkely
Dátum:	2024
ISSN:	2509-2715 2509-2723
Megjegyzések:	The Semmelweis Study is a prospective occupational cohort study that seeks to enroll all employees of Semmelweis University (Budapest, Hungary) aged 25 years and older, with a population of 8866 people, 70.5% of whom are women. The study builds on the successful experiences of the Whitehall II study and aims to investigate the complex relationships between lifestyle, environmental, and occupational risk factors, and the development and progression of chronic age-associated diseases. An important goal of the Semmelweis Study is to identify groups of people who are aging unsuccessfully and therefore have an increased risk of developing age-associated diseases. To achieve this, the study takes a multidisciplinary approach, collecting economic, social, psychological, cognitive, health, and biological data. The Semmelweis Study comprises a baseline data collection with open healthcare data linkage, followed by repeated data collection waves every 5 years. Data are collected through computer-assisted self-completed questionnaires, followed by a physical health examination, physiological measurements, and the assessment of biomarkers. This article provides a comprehensive overview of the Semmelweis Study, including its origin, context, objectives, design, relevance, and expected contributions.
Tárgyszavak:	Orvostudományok Egészségtudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk Age-associated diseases Biological age Central Europe Epidemiology Health Promoting University Healthy aging Workplace cohort
Megjelenés:	GeroScience. - 46 : 1 (2024), p. 191-218. -
További szerzők:	Tabák Ádám G. Ádány Róza (1952-) (megelőző orvostan és népegészségtan szakorvos) Purebl György Kaposvári Csilla Fazekas-Pongor Vince Csípő Tamás (1990-) Szarvas Zsófia Horváth Krisztián Mukli Péter Balog Róbert Bódizs Róbert Ujma Péter Stauder Adrienne Belsky, Daniel W. Kovács Illés Yabluchanskiy, Andriy Maier, Andrea B. Moizs Marianna (1964-) (orvos) Östlin Piroska Yon, Yongjie Varga Péter Vokó Zoltán (1968-) (epidemiológus) Papp Magor Csongor (1978-) (háziorvostan szakorvos) Takács István Vásárhelyi Barna Torzsa Péter Ferdinándy Péter Csiszár Anna Benyó Zoltán Szabó Attila (gyermekgyógyász Budapest) Dörnyei Gabriella Kivimäki, Mika Kellermayer Miklós Merkely Béla (1965-) (orvos)
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