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001-es BibID:	BIBFORM099924
035-os BibID:	(cikkazonosító)20994 (WOS)000711121600052 (Scopus)85108282219
Első szerző:	Csípő Tamás
Cím:	Sleep deprivation impairs cognitive performance, alters task-associated cerebral blood flow and decreases cortical neurovascular coupling-related hemodynamic responses / Csipo Tamas, Lipecz Agnes, Owens Cameron, Mukli Peter, Perry Jonathan W., Tarantini Stefano, Balasubramanian Priya, Nyúl-Tóth Ádám, Yabluchanska Valeriya, Sorond Farzaneh A., Kellawan J. Mikhail, Purebl György, Sonntag William E., Csiszar Anna, Ungvari Zoltan, Yabluchanskiy Andriy
Dátum:	2021
ISSN:	2045-2322
Megjegyzések:	Sleep deprivation (SD) is a common condition and an important health concern. In addition to metabolic and cardiovascular risks, SD associates with decreases in cognitive performance. Neurovascular coupling (NVC, "functional hyperemia") is a critical homeostatic mechanism, which maintains adequate blood supply to the brain during periods of intensive neuronal activity. To determine whether SD alters NVC responses and cognitive performance, cognitive and hemodynamic NVC assessments were conducted prior to and 24 h post-SD in healthy young male individuals (n?=?10, 27???3 years old). Cognition was evaluated with a battery of tests from the Cambridge Neuropsychological Test Automated Battery (CANTAB). Hemodynamic components of NVC were measured by transcranial Doppler sonography (TCD) during cognitive stimulation, dynamic retinal vessel analysis (DVA) during flicker light stimulation, and functional near infrared spectroscopy (fNIRS) during finger tapping motor task. Cognitive assessments revealed impairments in reaction time and sustained attention after 24 h of SD. Functional NIRS analysis revealed that SD significantly altered hemodynamic responses in the prefrontal cortex and somatosensory cortex during a motor task. NVC-related vascular responses measured by DVA and TCD did not change significantly. Interestingly, TCD detected decreased task-associated cerebral blood flow (CBF) in the right middle cerebral artery in sleep deprived participants. Our results demonstrate that 24 h of SD lead to impairments in cognitive performance together with altered CBF and hemodynamic components of cortical NVC responses.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk Cognitive neuroscience Neurological disorders Translational research
Megjelenés:	Scientific Reports. - 11 : 1 (2021), p. 1-13. -
További szerzők:	Lipécz Ágnes Owens, Cameron D. Mukli Péter Perry, Jonathan W. Tarantini, Stefano Balasubramanian, Priya Nyúl-Tóth Ádám Yabluchanska, Valeriya Sorond, Farzaneh A. Kellawan, J. Mikhail Purebl György Sonntag, William E. Csiszár Anna Ungvári Zoltán Yabluchanskiy, Andriy
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001-es BibID:	BIBFORM117772
035-os BibID:	(cikkazonosító)2303516 (Scopus)85180713903 (WoS)001133874100001
Első szerző:	Mukli Péter
Cím:	Impaired Neurovascular Coupling and Increased Functional Connectivity in the Frontal Cortex Predict Age-Related Cognitive Dysfunction / Mukli Peter, Pinto Camila B., Owens Cameron D., Csipo Tamas, Lipecz Agnes, Szarvas Zsofia, Peterfi Anna, Langley Ana Clara da Costa Pinaffi, Hoffmeister Jordan, Racz Frigyes Samuel, Perry Jonathan W., Tarantini Stefano, Nyúl-Tóth Ádám, Sorond Farzaneh A., Yang Yuan, James Judith A., Kirkpatrick Angelia C., Prodan Calin I., Toth Peter, Galindo Juliette, Gardner Andrew W., Sonntag William E., Csiszar Anna, Ungvari Zoltan, Yabluchanskiy Andriy
Dátum:	2023
ISSN:	2198-3844
Megjegyzések:	Impaired cerebrovascular function contributes to the genesis of age-related cognitive decline. In this study, the hypothesis is tested that impairments in neurovascular coupling (NVC) responses and brain network function predict cognitive dysfunction in older adults. Cerebromicrovascular and working memory function of healthy young (n = 21, 33.2?7.0 years) and aged (n = 30, 75.9?6.9 years) participants are assessed. To determine NVC responses and functional connectivity (FC) during a working memory (n-back) paradigm, oxy- and deoxyhemoglobin concentration changes from the frontal cortex using functional near-infrared spectroscopy are recorded. NVC responses are significantly impaired during the 2-back task in aged participants, while the frontal networks are characterized by higher local and global connection strength, and dynamic FC (p < 0.05). Both impaired NVC and increased FC correlate with age-related decline in accuracy during the 2-back task. These findings suggest that task-related brain states in older adults require stronger functional connections to compensate for the attenuated NVC responses associated with working memory load. ? 2023 The Authors. Advanced Science published by Wiley-VCH GmbH.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk aging cognitive decline functional connectivity functional near-infrared spectroscopy neurovascular coupling
Megjelenés:	Advanced Science. - 2023 (2023), p. 1-18. -
További szerzők:	Pinto, Camila B. Owens, Cameron D. Csípő Tamás (1990-) Lipécz Ágnes Szarvas Zsófia Péterfi Anna Langley, Ana Clara da Costa Pinaffi Hoffmeister, Jordan Rácz Frigyes Sámuel Perry, Jonathan W. Tarantini, Stefano Nyúl-Tóth Ádám Sorond, Farzaneh A. Yang, Yuan James, Judith A. Kirkpatrick, Angelia C. Prodan, Calin I. Tóth Péter Galindo, Juliette Gardner, Andrew W. Sonntag, William E. Csiszár Anna Ungvári Zoltán Yabluchanskiy, Andriy
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001-es BibID:	BIBFORM099921
035-os BibID:	(cikkazonosító)e02135
Első szerző:	Mukli Péter
Cím:	Sleep deprivation alters task-related changes in functional connectivity of the frontal cortex : a near-infrared spectroscopy study / Mukli Peter, Csipo Tamas, Lipecz Agnes, Stylianou Orestis, Racz Frigyes Samuel, Owens Cameron D., Perry Jonathan W., Tarantini Stefano, Sorond Farzaneh A., Kellawan Jeremy M., Purebl György, Yang Yuan, Sonntag William E., Csiszar Anna, Ungvari Zoltan I., Yabluchanskiy Andriy
Dátum:	2021
ISSN:	2162-3279
Megjegyzések:	Sleep deprivation (SD) is known to be associated with decreased cognitive performance; however, the underlying mechanisms are poorly understood. As interactions between distinct brain regions depend on mental state, functional brain networks established by these connections typically show a reorganization during task. Hence, analysis of functional connectivity (FC) could reveal the task-related change in the examined frontal brain networks. Our objective was to assess the impact of SD on static FC in the prefrontal and motor cortices and find whether changes in FC correlate with changes in neuropsychological scores. Healthy young male individuals (n = 10, 27.6 ? 3.7 years of age) participated in the study. A battery of tests from the Cambridge Neuropsychological Test Automated Battery (CANTAB) and 48 channel functional near-infrared spectroscopy (fNIRS) measurements were performed before and after 24 hr of SD. Network metrics were obtained by graph theoretical analysis using the fNIRS records in resting state and during finger-tapping sessions. During task, SD resulted in a significantly smaller decrease in the number and strength of functional connections (characterizing FC) in the frontal cortex. Changes in the global connection strengths correlated with decreased performance in the paired association learning test. These results indicate a global impact of SD on functional brain networks in the frontal lobes.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk functional connectivity near-infrared neuropsychological tests sleep deprivation spectroscopy
Megjelenés:	Brain and Behavior. - 11 : 8 (2021), p. 1-14. -
További szerzők:	Csípő Tamás (1990-) Lipécz Ágnes Stylianou, Orestis Rácz Frigyes Sámuel Owens, Cameron D. Perry, Jonathan W. Tarantini, Stefano Sorond, Farzaneh A. Kellawan, Jeremy M. Purebl György Yang, Yuan Sonntag, William E. Csiszár Anna Ungvári Zoltán Yabluchanskiy, Andriy
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