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001-es BibID:	BIBFORM099947
035-os BibID:	(WOS)000493706100001 (Scopus)85074834329
Első szerző:	Csípő Tamás
Cím:	Assessment of age-related decline of neurovascular coupling responses by functional near-infrared spectroscopy (fNIRS) in humans / Csipo Tamas, Mukli Peter, Lipecz Agnes, Tarantini Stefano, Bahadli Dhay, Abdulhussein Osamah, Owens Cameron, Kiss Tamas, Balasubramanian Priya, Nyúl-Tóth Ádám, Hand Rachel A., Yabluchanska Valeriya, Sorond Farzaneh A., Csiszar Anna, Ungvari Zoltan, Yabluchanskiy Andriy
Dátum:	2019
ISSN:	2509-2715 2509-2723
Megjegyzések:	Preclinical studies provide strong evidence that age-related impairment of neurovascular coupling (NVC) plays a causal role in the pathogenesis of vascular cognitive impairment (VCI). NVC is a critical homeostatic mechanism in the brain, responsible for adjustment of local cerebral blood flow to the energetic needs of the active neuronal tissue. Recent progress in geroscience has led to the identification of critical cellular and molecular mechanisms involved in neurovascular aging, identifying these pathways as targets for intervention. In order to translate the preclinical findings to humans, there is a need to assess NVC in geriatric patients as an endpoint in clinical studies. Functional near-infrared spectroscopy (fNIRS) is a non-invasive neuroimaging technique that enables the investigation of local changes in cerebral blood flow, quantifying task-related changes in oxygenated and deoxygenated hemoglobin concentrations. In the present overview, the basic principles of fNIRS are introduced and the application of this technique to assess NVC in older adults with implications for the design of studies on the mechanistic underpinnings of VCI is discussed.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk Aging Cognitive aging Functional near-infrared spectroscopy Neurovascular coupling VCI VCID Vascular cognitive impairment and dementia fNIRS
Megjelenés:	GeroScience. - 41 : 5 (2019), p. 495-509. -
További szerzők:	Mukli Péter Lipécz Ágnes Tarantini, Stefano Bahadli, Dhay Abdulhussein, Osamah Owens, Cameron D. Kiss Tamás (1950-) (vegyész) Balasubramanian, Priya Nyúl-Tóth Ádám Hand, Rachel A. Yabluchanska, Valeriya Sorond, Farzaneh A. Csiszár Anna Ungvári Zoltán Yabluchanskiy, Andriy
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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