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001-es BibID:	BIBFORM099948
035-os BibID:	(WOS)000500795500001 (Scopus)85075945416
Első szerző:	Lipécz Ágnes
Cím:	Microvascular contributions to age-related macular degeneration (AMD) : from mechanisms of choriocapillaris aging to novel interventions / Lipecz Agnes, Miller Lauren, Kovacs Illes, Czakó Cecília, Csipo Tamas, Baffi Judit, Csiszar Anna, Tarantini Stefano, Ungvari Zoltan, Yabluchanskiy Andriy, Conley Shannon
Dátum:	2019
ISSN:	2509-2715 2509-2723
Megjegyzések:	Aging of the microcirculatory network plays a central role in the pathogenesis of a wide range of age-related diseases, from heart failure to Alzheimer's disease. In the eye, changes in the choroid and choroidal microcirculation (choriocapillaris) also occur with age, and these changes can play a critical role in the pathogenesis of age-related macular degeneration (AMD). In order to develop novel treatments for amelioration of choriocapillaris aging and prevention of AMD, it is essential to understand the cellular and functional changes that occur in the choroid and choriocapillaris during aging. In this review, recent advances in in vivo analysis of choroidal structure and function in AMD patients and patients at risk for AMD are discussed. The pathophysiological roles of fundamental cellular and molecular mechanisms of aging including oxidative stress, mitochondrial dysfunction, and impaired resistance to molecular stressors in the choriocapillaris are also considered in terms of their contribution to the pathogenesis of AMD. The pathogenic roles of cardiovascular risk factors that exacerbate microvascular aging processes, such as smoking, hypertension, and obesity as they relate to AMD and choroid and choriocapillaris changes in patients with these cardiovascular risk factors, are also discussed. Finally, future directions and opportunities to develop novel interventions to prevent/delay AMD by targeting fundamental cellular and molecular aging processes are presented.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk Cardiovascular risk factors Choroidal thickness Hypertension OCTA Retina SD-OCT Smoking
Megjelenés:	GeroScience. - 41 : 6 (2019), p. 813-845. -
További szerzők:	Miller, Lauren Kovács Illés Czakó Cecília Csípő Tamás (1990-) Baffi Judit Csiszár Anna Tarantini, Stefano Ungvári Zoltán Yabluchanskiy, Andriy Conley, Shannon M.
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM117425
035-os BibID:	(Scopus)85179338215 (WoS)001115572500001
Első szerző:	Ungvári Zoltán
Cím:	The Semmelweis Study : a longitudinal occupational cohort study within the framework of the Semmelweis Caring University Model Program for supporting healthy aging / Zoltan Ungvari, Adam G. Tabák, Roza Adany, György Purebl, Csilla Kaposvári, Vince Fazekas-Pongor, Tamás Csípő, Zsófa Szarvas, Krisztián Horváth, Peter Mukli, Piroska Balog, Robert Bodizs, Peter Ujma, Adrienne Stauder, Daniel W. Belsky, Illés Kovács, Andriy Yabluchanskiy, Andrea B. Maier, Mariann Moizs, Piroska Östlin, Yongjie Yon, Péter Varga, Zoltán Vokó, Magor Papp, István Takács, Barna Vásárhelyi, Péter Torzsa, Péter Ferdinandy, Anna Csiszar, Zoltán Benyó, Attila J. Szabó, Gabriella Dörnyei, Mika Kivimäki, Miklos Kellermayer, Bela Merkely
Dátum:	2024
ISSN:	2509-2715 2509-2723
Megjegyzések:	The Semmelweis Study is a prospective occupational cohort study that seeks to enroll all employees of Semmelweis University (Budapest, Hungary) aged 25 years and older, with a population of 8866 people, 70.5% of whom are women. The study builds on the successful experiences of the Whitehall II study and aims to investigate the complex relationships between lifestyle, environmental, and occupational risk factors, and the development and progression of chronic age-associated diseases. An important goal of the Semmelweis Study is to identify groups of people who are aging unsuccessfully and therefore have an increased risk of developing age-associated diseases. To achieve this, the study takes a multidisciplinary approach, collecting economic, social, psychological, cognitive, health, and biological data. The Semmelweis Study comprises a baseline data collection with open healthcare data linkage, followed by repeated data collection waves every 5 years. Data are collected through computer-assisted self-completed questionnaires, followed by a physical health examination, physiological measurements, and the assessment of biomarkers. This article provides a comprehensive overview of the Semmelweis Study, including its origin, context, objectives, design, relevance, and expected contributions.
Tárgyszavak:	Orvostudományok Egészségtudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk Age-associated diseases Biological age Central Europe Epidemiology Health Promoting University Healthy aging Workplace cohort
Megjelenés:	GeroScience. - 46 : 1 (2024), p. 191-218. -
További szerzők:	Tabák Ádám G. Ádány Róza (1952-) (megelőző orvostan és népegészségtan szakorvos) Purebl György Kaposvári Csilla Fazekas-Pongor Vince Csípő Tamás (1990-) Szarvas Zsófia Horváth Krisztián Mukli Péter Balog Róbert Bódizs Róbert Ujma Péter Stauder Adrienne Belsky, Daniel W. Kovács Illés Yabluchanskiy, Andriy Maier, Andrea B. Moizs Marianna (1964-) (orvos) Östlin Piroska Yon, Yongjie Varga Péter Vokó Zoltán (1968-) (epidemiológus) Papp Magor Csongor (1978-) (háziorvostan szakorvos) Takács István Vásárhelyi Barna Torzsa Péter Ferdinándy Péter Csiszár Anna Benyó Zoltán Szabó Attila (gyermekgyógyász Budapest) Dörnyei Gabriella Kivimäki, Mika Kellermayer Miklós Merkely Béla (1965-) (orvos)
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