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001-es BibID:	BIBFORM065219
Első szerző:	Molvarec Attila (szülész-nőgyógyász)
Cím:	Comparison of placental growth factor and fetal flow Doppler ultrasonography to identify fetal adverse outcomes in women with hypertensive disorders of pregnancy : an observational study / Attila Molvarec, Nóra Gullai, Balázs Stenczer, Gergely Fügedi, Bálint Nagy, János Rigó Jr.
Dátum:	2013
Megjegyzések:	Background:Hypertensive disorders of pregnancy and intrauterine growth restriction (IUGR) are leading causes ofmaternal and perinatal morbidity and mortality. Failure to detect intrauterine growth restriction in women at highrisk has been highlighted as a significant avoidable cause of serious fetal outcome. In this observational study wecompare fetal flow using Doppler ultrasonography with a new test for placental growth factor (PlGF) to predictfetal adverse events.Methods:Eighty-nine women with hypertensive disorders of pregnancy (24 with chronic hypertension, 17 withgestational hypertension, 12 with HELLP syndrome, 19 with preeclampsia and 17 with superimposed preeclampsia)were enrolled. A single maternal blood sample to measure free PlGF (Alere Triage) taken before 35 weeks ofpregnancy was compared to the last Doppler ultrasound measurement of fetal flow before delivery. PlGF wasclassified as normal (PlGF?100 pg/ml), low (12<PlGF<100) or very low (PlGF?12 pg/ml). A positive test for abnormalfetal flow was defined as either signs of centralisation of the fetal circulation or diastolic block or reverse flow in theumbilical artery or descending aorta; this was a criterion for delivery. Fetal outcomes were intrauterine growthrestriction and birth before 37 weeks of pregnancy.Results:In total 61/89 women had a preterm birth and 22 infants had IUGR. Of those who delivered preterm,20/20 women with abnormal fetal flow and 36/41 (87.8%) women with normal fetal flow had low or very low PlGF.Of those infants with IUGR, 22/22 had low or very low maternal PlGF and 10/22 had abnormal fetal flow.Conclusions:PlGF may provide useful information before 35th gestational week to identify fetuses requiring urgentdelivery, and those at risk of later adverse outcomes not identified by fetal flow Doppler ultrasonography.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban hypertension placental growth factor PlGF IUGR preeclampsia
Megjelenés:	BMC Pregnancy and Child Birth 13 (2013), p. 1-7. -
További szerzők:	Gullai Nóra Stenczer Balázs Fügedi Gergely Nagy Bálint (1956-) (molekuláris genetikus) Rigó János (1958-) (szülész-nőgyógyász)
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