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001-es BibID:	BIBFORM065313
Első szerző:	Iffy, Leslie
Cím:	The risk of shoulder dystocia related permanent fetal injury in relation to birth weight / Leslie Iffy, Michael Brimacombe, Joseph J. Apuzzio, Valeria Varadi, Nuris Portuondo, Balint Nagy
Dátum:	2008
ISSN:	0301-2115
Megjegyzések:	OBJECTIVE:To examine birth weight related risks of fetal injury in connection with shoulder dystocia.STUDY DESIGN:The investigation was based on a retrospective analysis of 316 fetal neurological injuries associated with deliveries complicated by arrest of the shoulders that occurred across the United States.RESULTS:The study revealed that the distribution of birthweights for the high risk shoulder dystocia population differs from the standard birthweight distribution. The relative difference per birthweight interval is used to adjust an assumed 1:1000 baseline risk of injury due to shoulder dystocia following vaginal deliveries. These adjusted risks show a need to consider new thresholds for elective cesarean delivery.CONCLUSIONS:Current North American and British guidelines, that set 5000 g as minimum estimated fetal weight limit for elective cesarean section in non-diabetic and 4500 g for diabetic gravidas, may expose some macrosomic fetuses to a high risk of permanent neurological damage. The authors present the opinion that the mother, having been informed of the risks of vaginal versus abdominal delivery, should be allowed to play an active role in the critical management decisions.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban shoulder dystocia birth weight risk
Megjelenés:	European Journal Of Obstetrics Gynecology And Reproductive Biology 136 : 1 (2008), p. 53-60. -
További szerzők:	Brimacombe, Michael Apuzzio, Joseph J. Váradi Valéria Portuondo, Nuris Nagy Bálint (1956-) (molekuláris genetikus)
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001-es BibID:	BIBFORM065298
Első szerző:	Madách Krisztina
Cím:	Elevated serum 70 kDa heat shock protein level reflects tissue damage and disease severity in the syndrome of hemolysis, elevated liver enzymes, and low platelet count / Krisztina Madách, Attila Molvarec, János Rigó Jr., Bálint Nagy, István Pénzes, István Karádi, Zoltán Prohászka
Dátum:	2008
ISSN:	0301-2115
Megjegyzések:	We have recently demonstrated that serum 70 kDa heat shock protein (Hsp70) levels are increased in the syndrome of hemolysis, elevated liver enzymes, and low platelet count (HELLP syndrome). The aim of the present study was to investigate in an independent, larger cohort of patients whether serum Hsp70 levels are related to laboratory markers of HELLP syndrome.STUDY DESIGN:The study population included 14 patients with HELLP syndrome. Serum Hsp70 levels were measured by enzyme-linked immunosorbent assay. The relationship between serum Hsp70 levels and laboratory markers of hemolysis, hepatocellular damage, renal insufficiency, inflammation or disseminated intravascular coagulation (DIC), as well as platelet count was investigated by calculating correlation coefficients, standardized regression coefficients and by principal component analysis.RESULTS:Serum Hsp70 levels showed a very strong correlation to the markers of hemolysis (plasma free hemoglobin level, serum lactate dehydrogenase activity, and total bilirubin level) and of hepatocellular injury (serum aminotransferase activities), supported also by principal component analysis. Furthermore, circulating Hsp70 concentration reflected the severity of HELLP syndrome as expressed by the significant inverse correlation to the lowest platelet count. By contrast, there was no relationship between serum Hsp70 levels and markers of inflammation, coagulation, fibrinolysis or renal insufficiency.CONCLUSION:Elevated serum 70 kDa heat shock protein level seems to reflect tissue damage (hemolysis and hepatocellular injury) and disease severity in patients with HELLP syndrome. However, further investigations are needed to determine the clinical relevance of these findings.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban heat shock elevated HELLP syndrome
Megjelenés:	European Journal Of Obstetrics Gynecology And Reproductive Biology 139 : 2 (2008), p. 133-138. -
További szerzők:	Molvarec Attila (szülész-nőgyógyász) Rigó János (1958-) (szülész-nőgyógyász) Nagy Bálint (1956-) (molekuláris genetikus) Pénzes István Karádi István (1952-) (belgyógyász, kardiológus) Prohászka Zoltán
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001-es BibID:	BIBFORM065214
Első szerző:	Rigó János (szülész-nőgyógyász)
Cím:	Trends in maternal mortality in Hungary between 1978 and 2010 / János Rigó Jr., György Csákány, Marcella Laky, Bálint Nagy, Endre Horváth, József Gábor Joó
Dátum:	2014
ISSN:	0301-2115
Megjegyzések:	OBJECTIVE:We evaluated the trends of the last decades in maternal mortality in Hungary and compared Hungarian results with those of other European countries.STUDY DESIGN:Cases of maternal death in Hungary during the study period from calendar year 1978 to 2010 were analyzed in a retrospective manner to characterize mortality distribution and to identify potential clinical or demographic predictors. Data in all cases were extracted both from the national Obstetric Registry operated by the National Institute of Gynecology and Obstetrics, from the Hungarian Central Bureau of Statistics and from the National Public Health and Medical Officer Service. Detailed clinical data were obtained based on obligatory reporting by individual clinical institutions.RESULTS:The annual maternal mortality rate (MMR) was 26.7 per 100,000 live births in the period 1978-1987 and declined significantly to 10.9 per 100,000 live births in the period 1997-2010. In the period 1988-1996 (with missing associated clinical and demographic data) the MMR was 16.4 per 100,000 live births. The proportion of delivery-associated causes of death increased significantly between the two study periods from 49.4% to 62.9% (p<0.05). Among obstetric causes of death, the rate of thromboembolism showed a significant increase, while there was a trend toward a decline in rate of maternal deaths attributable to hemorrhagic shock. Among medical causes of death not directly attributable to obstetric complications, the rate of renal and gastrointestinal etiologies declined significantly throughout the study periods.CONCLUSIONS:We observed a marked decline in maternal mortality during the last few decades in Hungary. Recent changes in mortality distribution highlight current characteristics of pregnancy care in Hungary and may help identify strategies for future improvement.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban Maternal mortality Hungary Obstetric
Megjelenés:	European Journal Of Obstetrics Gynecology And Reproductive Biology 173 (2014), p. 29-33. -
További szerzők:	Csákány György Laky Marcella Nagy Bálint (1956-) (molekuláris genetikus) Horváth Endre Joó József Gábor (1965-) (szülész-nőgyógyász)
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001-es BibID:	BIBFORM065305
Első szerző:	Rosta Klára
Cím:	Association of extracellular superoxide dismutase (SOD3) Ala40Thr gene polymorphism with pre-eclampsia complicated by severe fetal growth restriction / Klára Rosta, Attila Molvarec, Anna Enzsöly, Bálint Nagy, Zsolt Rónai, Andrea Fekete, Mária Sasvári-Székely, János Rigó Jr., Ágota Vér
Dátum:	2009
ISSN:	0301-2115
Megjegyzések:	Placental and systemic oxidative stress with an imbalance in the oxidant/antioxidant activity seems to play a central role in the pathogenesis of pre-eclampsia. The aim of our study was to examine whether two missense polymorphisms of the extracellular superoxide dismutase (SOD3) gene (Arg213Gly and Ala40Thr) are associated with pre-eclampsia in a Caucasian population from Hungary.Study designOne hundred and fifty-nine pre-eclamptic patients and 114 normotensive, healthy pregnant women were involved in this case-control study. The SOD3 Arg213Gly and Ala40Thr genotypes were determined using the polymerase chain reaction-restriction length polymorphism (PCR-RFLP) and allele-specific amplification methods.ResultsThe Arg213Gly variant was not detected in our population. There were no significant differences in the genotype and allele frequencies of the SOD3 Ala40Thr polymorphism between pre-eclamptic patients and control subjects. However, the mutant allele carriers of this polymorphism showed an increased risk for severe fetal growth restriction-complicated pre-eclampsia, which was independent of maternal age, prepregnancy BMI, primiparity and smoking status (OR: 6.07, 95% CI: 1.33?27.8, p = 0.020; adjusted OR: 4.89, 95% CI: 1.03?23.2, p = 0.046).ConclusionOur results suggest a role of SOD3 Ala40Thr single nucleotide polymorphism in the risk of severe fetal growth restriction-complicated pre-eclampsia. However, further studies are needed with a larger sample size to confirm our findings and to explore the exact molecular basis of this observation.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban superoxide dismutase Ala40Ther gene polymorphism
Megjelenés:	European Journal Of Obstetrics Gynecology And Reproductive Biology. - 142 : 2 (2009), p. 134-138. -
További szerzők:	Molvarec Attila (szülész-nőgyógyász) Enzsöly Anna Nagy Bálint (1956-) (molekuláris genetikus) Rónai Zsolt Fekete Andrea Sasvári-Székely Mária Rigó János (1958-) (szülész-nőgyógyász) Vér Ágota
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