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001-es BibID:BIBFORM073617
Első szerző:Gullai Nóra
Cím:Evaluation of a rapid and simple placental growth factor test in hypertensive disorders of pregnancy / Nóra Gullai, Balázs Stenczer, Attila Molvarec, Gergely Fügedi, Zoltán Veresh, Bálint Nagy, János Rigó Jr.
Dátum:2013
ISSN:0916-9636
Megjegyzések:The aim of this study was to investigate the diagnostic accuracy of the Triage placental growth factor (PlGF) assay, together with its prognostic efficiency in determining the need for preterm delivery in all forms of hypertensive disorders of pregnancy. A total of 130 pregnant women with a diagnosis of preeclampsia (PE: 23), HELLP syndrome (20), superimposed preeclampsia (SIPE: 17), chronic hypertension (CHT: 25), gestational hypertension (GHT: 18) and 27 normotensive pregnant controls were enrolled in this case-control study. A single blood sample was taken between 22 and 34 weeks of gestation, and the plasma was analyzed for PlGF using the Alere Triage PlGF assay. The PlGF levels found in all hypertensive disorder groups differed significantly from those observed in controls. There was a highly significant difference in PlGF concentrations between women with a pregnancy duration <35 weeks and controls. Using a gestational age-dependent threshold of 5% of normal, a positive PlGF test predicted delivery before 35 weeks in 93.7% of hypertensive women and delivery before 37 weeks in 90.5% of hypertensive women. A positive PlGF test identified the following proportions of hypertensive patients: 95.7% (PE), 95.0% (HELLP syndrome), 82.4% (SIPE), 60.0% (CHT) and 44.4% (GHT). A positive PlGF test was associated with a significantly shorter duration of pregnancy (hazard ratio of 3.43 adjusted for the gestational age at the time of sample collection and hypertension with proteinuria). In conclusion, PlGF concentrations are significantly lower in all hypertensive disorders. A positive test using the Triage PlGF assay at 22-34 weeks of gestation predicts delivery before 37 weeks in women with both proteinuric and non-proteinuric hypertensive disorders of pregnancy.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
hypertension
pregnancy
placental
growth
Megjelenés:Hypertension Research 36 : 5 (2013), p. 457-462. -
További szerzők:Stenczer Balázs Molvarec Attila (szülész-nőgyógyász) Fügedi Gergely Veresh Zoltán Nagy Bálint (1956-) (molekuláris genetikus) Rigó János (1958-) (szülész-nőgyógyász)
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001-es BibID:BIBFORM065232
Első szerző:Molvarec Attila (szülész-nőgyógyász)
Cím:Circulating angiogenic factors determined by electrochemiluminescence immunoassay in relation to the clinical features and laboratory parameters in women with pre-eclampsia / Attila Molvarec, András Szarka, Szilvia Walentin, Endre Szűcs, Bálint Nagy, János Rigó Jr.
Dátum:2010
ISSN:0916-9636
Megjegyzések:The purpose of this study was to determine whether increased serum soluble fms-like tyrosine kinase-1 (sFlt-1) and decreasedplacental growth factor (PlGF) levels in pre-eclampsia are related to the clinical features and laboratory parameters of thepatients, including markers of inflammation, endothelial activation and injury, oxidative stress and trophoblast debris. A total of54 pre-eclamptic patients, 58 healthy pregnant and 52 healthy non-pregnant women were involved in this case?control study.Serum sFlt-1 and PlGF levels were measured by electrochemiluminescence immunoassay. Serum levels of sFlt-1 and PlGF weresignificantly higher in pre-eclamptic patients and healthy pregnant women than in healthy non-pregnant women. In addition,pre-eclamptic patients had significantly higher sFlt-1 levels and significantly lower PlGF concentrations compared with healthy pregnant women. According to the subgroup analyses, sFlt-1 levels were significantly higher in severely pre-eclamptic patients than in those with mild pre-eclampsia, whereas pre-eclamptic patients with fetal growth restriction or preterm onset of the disease had significantly lower PlGF concentrations compared with those without intrauterine growth restriction or with a diseaseonset at term. In the pre-eclamptic group, there were significant positive correlations between serum sFlt-1 levels and systolic and diastolic blood pressure, serum levels of blood urea nitrogen and creatinine, as well as plasma levels of von Willebrand factor antigen, fibronectin and cell-free fetal DNA. Furthermore, serum PlGF concentrations of pre-eclamptic patients showedsignificant positive correlations with gestational age at disease onset and delivery, as well as with fetal birth weight, and significant inverse correlations with levels of blood urea nitrogen, creatinine and fibronectin. In conclusion, increased serum sFlt-1 and decreased PlGF levels are associated with blood pressure, renal and endothelial dysfunction, trophoblast deportation, as well as with a shorter duration of pregnancy, fetal growth restriction, the severity and preterm onset of the disease in pre-eclampsia. These findings indicate the central role of an angiogenic imbalance in the pathogenesis of this pregnancy-specific disorde
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
circulating
Angiogenic
preeclampsia
factors
Megjelenés:Hypertension Research 33 : 9 (2010), p. 892-898. -
További szerzők:Szarka András Walentin Szilvia Szűcs Endre Nagy Bálint (1956-) (molekuláris genetikus) Rigó János (1958-) (szülész-nőgyógyász)
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DOI
Intézményi repozitóriumban (DEA) tárolt változat
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