Találati lista | Tudóstér

001-es BibID:	BIBFORM074807
Első szerző:	Nagy Bálint (molekuláris genetikus)
Cím:	Apolipoprotein E alleles in women with severe pre-eclampsia / B. Nagy, J. Rigó Jr., L. Fintor, I. Karádi, T. Tóth
Dátum:	1998
ISSN:	0021-9746
Megjegyzések:	This study investigated the frequency of apolipoprotein E (apoE) alleles among women with severe pre-eclampsia. The presence of the three most common apoE alleles (epsilon 2, epsilon 3, epsilon 4) was determined by polymerase chain reaction-restriction fragment length polymorphism in three groups of white women: non-pregnant healthy (n = 101), pregnant healthy (n = 52), and pregnant with a diagnosis of severe pre-eclampsia (n = 54). The frequency of apo epsilon 2 was highest among women with severe pre-eclampsia (16.6%) followed by non-pregnant women (12.9%), and those experiencing a healthy pregnancy (10.6%). The higher frequency of the apo epsilon 2 allele detected among women with severe pre-eclampsia suggests that apoE may play a role in the development of pre-eclampsia.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban apolipoprotein E pre-eclampsia alleles
Megjelenés:	Journal of Clinical Pathology. - 51 : 4 (1998), p. 324-325. -
További szerzők:	Rigó János (1958-) (szülész-nőgyógyász) Fintor, Lou Karádi István (1952-) (belgyógyász, kardiológus) Tóth T.
Internet cím:	Szerző által megadott URL Intézményi repozitóriumban (DEA) tárolt változat DOI
Borító:
Saját polcon:

001-es BibID:	BIBFORM073613
Első szerző:	Nagy Bálint (molekuláris genetikus)
Cím:	Apolipoprotein E Allele Distribution in Trisomy 13, 18, and 21 Conceptuses in a Hungarian Population / Bálint Nagy, Zoltán Bán, Ernö Tóth-Pál, Csaba Papp, Lou Fintor, Zoltán Papp
Dátum:	2000
ISSN:	0002-9173
Megjegyzések:	Reports documented a higher frequency of apolipoprotein E (apoE) allele epsilon 4 among mothers of children diagnosed with Down syndrome. We studied the prevalence of apoE alleles among 56 conceptuses with trisomy 13, trisomy 18, or trisomy 21. The presence of the 3 most common apoE alleles (epsilon 2, epsilon 3, epsilon 4) was determined by polymerase chain reaction-restriction fragment length polymorphism, and trisomy status was detected by fluorescent polymerase chain reaction followed by DNA fragment analysis and by conventional cytologic methods. We found no significant difference in the distribution of apoE alleles in the group of trisomy 21 fetuses compared with samples from healthy blood donors. The odds of having trisomy 18 for the apoE epsilon 4 group was 3-fold as high as for apoE epsilon 3 allele compared with the healthy control group. Furthermore, a statistically significant association was found for those with trisomy 18 and apoE epsilon 4, while for those with trisomy 13 and apoE epsilon 4, the test showed no significant association. The observed apoE allele epsilon 3 frequencies among patients with Down syndrome and healthy control subjects may help explain and support previous work that did not find high rates of atherosclerosis among these persons. The role of apoE alleles in the development of trisomies needs further study.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban apolopoprotein E preeclampsia alleles
Megjelenés:	American Journal of Clinical Pathology. - 113 : 4 (2000), p. 535-538. -
További szerzők:	Bán Zoltán (nőgyógyász) Tóth-Pál Ernő (nőgyógyász) Papp Csaba (1966-) (aneszteziológus és intenzív terápiás szakorvos) Fintor, Lou Papp Zoltán (1942-) (szülész-nőgyógyász, genetikus)
Internet cím:	Szerző által megadott URL DOI
Borító:
Saját polcon: