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1.

001-es BibID:BIBFORM065207
Első szerző:Fazakas Ádám
Cím:Genetic predisposition in patients with hypertension and normal ejection fraction to oxidative stress / Fazakas Ádám, Szelényi Zsuzsanna, Szénási Gábor, Nyírő Gábor, Szabó Péter M., Patócs Attila, Tegze Narcis, Fekete Bertalan C., Molvarec Attila, Nagy Bálint, Jakus Judit, Örsi Ferenc, Karádi István, Vereckei András
Dátum:2016
ISSN:1933-1711 1878-7436
Megjegyzések:The role of oxidative stress (OXS) due to myocardial nitric oxide synthase (NOS) uncoupling related to oxidative depletion of its cofactor tetrahydrobiopterin (BH4) emerged in the pathogenesis of heart failure with preserved ejection fraction. We determined the prevalence of six single nucleotide polymorphisms (SNPs) of genes encoding enzymes related to OXS, BH4 metabolism, and NOS function in ?60-year-old 94 patients with hypertension and 18 age-matched controls with normal ejection fraction. Using echocardiography, 56/94 (60%) patients with hypertension had left ventricular (LV) diastolic dysfunction (HTDD+ group) and 38/94 (40%) patients had normal LV diastolic function (HTDD? group). Four SNPs (rs841, rs3783641, rs10483639, and rs807267) of guanosine triphosphate cyclohydrolase-1, the rate-limiting enzyme in BH4 synthesis, one (rs4880) of manganese superoxide dismutase, and one (rs1799983) of endothelial NOS genes were genotyped using real-time polymerase chain reaction method and Taqman probes. Protein carbonylation, BH4, and total biopterin levels were measured from plasma samples. No between-groups difference in minor allele frequency of SNPs was found. We calculated a genetic score indicating risk for OXS based on the minor allele frequencies of the SNPs. A high genetic risk for OXS was significantly associated with HTDD+ even after adjustment for confounding variables (odds ratio [95% confidence interval]:4.79 [1.12?20.54]; P = .035). In both patient groups protein carbonylation (P < .05 for both), plasma BH4 (P < .01 for both) and in the HTDD+ group total biopterin (P < .05) increased versus controls. In conclusion, in patients with hypertension and normal ejection fraction, a potential precursor of heart failure with preserved ejection fraction, a partly genetically determin
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
heart failure
Hypertension
oxidative stress
Megjelenés:Journal of the American Society of Hypertension 10 : 2 (2016), p. 124-132. -
További szerzők:Szelényi Zsuzsanna Szénási Gábor Nyírő Gábor (molekuláris biológus) Szabó Péter M. Patócs Attila Tegze, Narcis Fekete Bertalan C. Molvarec Attila (szülész-nőgyógyász) Nagy Bálint (1956-) (molekuláris genetikus) Jakus Judit Örsi Ferenc Karádi István (1952-) (belgyógyász, kardiológus) Vereckei András
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2.

001-es BibID:BIBFORM065356
Első szerző:Kalina Ákos
Cím:The association of serum lipoprotein(a) levels, apolipoprotein(a) size and (TTTTA)n polymorphism with coronary heart disease / Akos Kalina, Albert Csaszar, George Fust, Balint Nagy, Csaba Szalai, Istvan Karadi, Jeno Duba, Zoltan Prohaszka, Laura Horvath, Hans Dieplinger
Dátum:2001
ISSN:0009-8981
Megjegyzések:Background: The association between lipoprotein(a) levels, apolipoprotein(a) size and the (TTTTA)n polymorphism which is located in the 5· non-coding region of the apo(a) gene was studied in 263 patients with severe coronary heart disease and 97 healthy subjects. Methods: Lp(a) levels were measured by ELISA, apo(a) isoform size was determined by SDS?agarose gel electrophoresis, and analysis of the (TTTTA)n was carried out by PCR. For statistical calculation, both groups were divided into low (at least one apo(a) isoform with ?22 Kringle IV) and high (both isoforms with >22 KIV) apo(a) isoform sizes, and into low number (<10 in both alleles) and high number of (?10 at least one allele) TTTTA repeats. Results: Lp(a) levels were higher (P=0.007), apo(a) isoforms size ?22 KIV and TTTTA repeats ?10 were more frequent (P=0.007 and 0.01) in cases than in controls. Lp(a) levels were found to be increased with low apo(a) weight in both groups (both P<0.0001). In multivariate logistic regression analysis, only the Lp(a) levels (P=0.005) and (TTTTA)n polymorphism (P=0.002) were found to be significantly associated with CHD. Conclusion: Nevertheless, these results indicate that in CHD patients the (TTTTA)n polymorphism has an effect on Lp(a) levels which is independent of the apo(a) size.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
apolipoprotein(a)
(TTTTA)n
Polymorphism
serum
association
coronary
heart
diseases
Megjelenés:Clinica Chimica Acta. - 309 : 1 (2001), p. 45-51. -
További szerzők:Császár Albert Füst György (Budapest) Nagy Bálint (1956-) (molekuláris genetikus) Szalai Csaba Karádi István (1952-) (belgyógyász, kardiológus) Duba Jenő Prohászka Zoltán Horváth Laura Dieplinger, Hans
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3.

001-es BibID:BIBFORM065298
Első szerző:Madách Krisztina
Cím:Elevated serum 70 kDa heat shock protein level reflects tissue damage and disease severity in the syndrome of hemolysis, elevated liver enzymes, and low platelet count / Krisztina Madách, Attila Molvarec, János Rigó Jr., Bálint Nagy, István Pénzes, István Karádi, Zoltán Prohászka
Dátum:2008
ISSN:0301-2115
Megjegyzések:We have recently demonstrated that serum 70 kDa heat shock protein (Hsp70) levels are increased in the syndrome of hemolysis, elevated liver enzymes, and low platelet count (HELLP syndrome). The aim of the present study was to investigate in an independent, larger cohort of patients whether serum Hsp70 levels are related to laboratory markers of HELLP syndrome.STUDY DESIGN:The study population included 14 patients with HELLP syndrome. Serum Hsp70 levels were measured by enzyme-linked immunosorbent assay. The relationship between serum Hsp70 levels and laboratory markers of hemolysis, hepatocellular damage, renal insufficiency, inflammation or disseminated intravascular coagulation (DIC), as well as platelet count was investigated by calculating correlation coefficients, standardized regression coefficients and by principal component analysis.RESULTS:Serum Hsp70 levels showed a very strong correlation to the markers of hemolysis (plasma free hemoglobin level, serum lactate dehydrogenase activity, and total bilirubin level) and of hepatocellular injury (serum aminotransferase activities), supported also by principal component analysis. Furthermore, circulating Hsp70 concentration reflected the severity of HELLP syndrome as expressed by the significant inverse correlation to the lowest platelet count. By contrast, there was no relationship between serum Hsp70 levels and markers of inflammation, coagulation, fibrinolysis or renal insufficiency.CONCLUSION:Elevated serum 70 kDa heat shock protein level seems to reflect tissue damage (hemolysis and hepatocellular injury) and disease severity in patients with HELLP syndrome. However, further investigations are needed to determine the clinical relevance of these findings.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
heat shock
elevated
HELLP syndrome
Megjelenés:European Journal Of Obstetrics Gynecology And Reproductive Biology 139 : 2 (2008), p. 133-138. -
További szerzők:Molvarec Attila (szülész-nőgyógyász) Rigó János (1958-) (szülész-nőgyógyász) Nagy Bálint (1956-) (molekuláris genetikus) Pénzes István Karádi István (1952-) (belgyógyász, kardiológus) Prohászka Zoltán
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4.

001-es BibID:BIBFORM065241
Első szerző:Molvarec Attila (szülész-nőgyógyász)
Cím:Circulating anti-heat-shock-protein antibodies in normal pregnancy and preeclampsia / Attila Molvarec, Zoltán Derzsy, Judit Kocsis, Tamás Bőze, Bálint Nagy, Krisztián Balogh, Veronika Makó, László Cervenak, Miklós Mézes, István Karádi, Zoltán Prohászka, János Rigó Jr.
Dátum:2009
ISSN:1355-8145
Megjegyzések:It has been previously reported that circulating anti-heat-shock-protein (Hsp) antibody levels are elevated in cardiovascular disorders. The aim of the present study was to determine circulating antihuman Hsp60, antimycobacterial Hsp65, and antihuman Hsp70 antibody levels in healthy pregnant women and preeclamptic patients and to investigate their relationship to the clinical characteristics of the study subjects, as well as to the markers of inflammation (C-reactive protein (CRP)), endothelial activation (von Willebrand factor antigen), or endothelial injury (fibronectin), oxidative stress (malondialdehyde) and to serum Hsp70 levels. Ninety-three preeclamptic patients and 127 normotensive healthy pregnant women were involved in this case control study. Serum anti-Hsp60, anti-Hsp65, anti-Hsp70, and Hsp70 levels were measured with enzyme-linked immunosorbent assay (ELISA). Serum CRP levels were determined by an autoanalyzer using the manufacturer's kit. Plasma von Willebrand factor antigen levels were quantified by ELISA, while plasma fibronectin concentration by nephelometry. Plasma malondialdehyde levels were measured by the thiobarbituric-acid-based colorimetric assay. For statistical analyses, nonparametric methods were applied. Anti-Hsp60, anti-Hsp65, and anti-Hsp70 antibodies were detected in all of our serum samples. There were no significant differences in serum anti-Hsp60, anti-Hsp65, and anti-Hsp70 antibody levels between the control and preeclamptic groups. Serum levels of Hsp70 and CRP, as well as plasma levels of VWF antigen, fibronectin, and malondialdehyde, were significantly higher in preeclamptic patients than in normotensive healthy pregnant women. Serum anti-Hsp60 antibody levels showed significant correlations with serum anti-Hsp65 antibody levels both in the control and the preeclamptic groups (Spearman R?=?0.55 and 0.59; p?<?0.001, respectively). However, no other relationship was found between clinical features (maternal age, smoking status, parity, body mass index, gestational age at blood draw, systolic and diastolic blood pressure, gestational age at delivery, and fetal birth weight) and measured laboratory parameters of the study subjects and serum anti-Hsp antibody levels in either study group. In conclusion, anti-Hsp60 and anti-Hsp70 antibodies as naturally occurring autoantibodies are present in the peripheral circulation of healthy pregnant women. Nevertheless, humoral immunity against heat shock proteins was not associated with preeclampsia. Further studies are warranted to explore the role of heat shock proteins and immune reactivity to them in the immunobiology of normal pregnancy and preeclampsia.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
circulating
anti heatschock
protein
preeclampsia
Megjelenés:Cell Stress & Chaperones. - 14 : 5 (2009), p. 491-498. -
További szerzők:Derzsy Zoltán Kocsis Judit (1967-) (onkológus) Bőze Tamás Nagy Bálint (1956-) (molekuláris genetikus) Balogh Krisztián Makó Veronika Cervenak László Mézes Miklós Karádi István (1952-) (belgyógyász, kardiológus) Prohászka Zoltán Rigó János (1958-) (szülész-nőgyógyász)
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5.

001-es BibID:BIBFORM065315
Első szerző:Molvarec Attila (szülész-nőgyógyász)
Cím:Lipid, haemostatic and inflammatory variables in relation to the estrogen receptor [alfa] (ESR1) PvuII and XbaI gene polymorphisms / Molvarec Attila, Nagy Bálint, Kovács Margit, Walentin Szilvia, Imreh Éva, Rigó János Jr., Szalay János, Füst George, Prohászka Zoltán, Karádi István
Dátum:2007
ISSN:0009-8981
Megjegyzések:Estrogen is known to affect lipoprotein metabolism, the haemostatic system and inflammatory markers. Our aim was to determine whether estrogen receptor alpha (ESR1) PvuII and XbaI gene polymorphisms can influence lipid, haemostatic and inflammatory variables in healthy Caucasian women and men of reproductive age.METHODS:58 healthy women (aged between 18 and 45 years) and 55 healthy men (aged between 21 and 45 years) of reproductive age were enrolled in our study. FSH levels, lipid (total cholesterol, triglyceride, HDL cholesterol, lipoprotein(a), apo A-I, apo B), haemostatic (prothrombin time, activated partial thromboplastin time (aPTT), thrombin time, fibrinogen, factor V, VII, VIII, protein C, protein S, antithrombin III) and inflammatory (CRP) variables were measured on autoanalyzers using commercially available kits. Serum VLDL and LDL cholesterol concentrations were calculated with the equation of Friedewald. The ESR1 PvuII and XbaI genotypes were determined with PCR-RFLP method.RESULTS:In the total group, the ESR1 XbaI GG genotype carriers had significantly higher serum lipoprotein(a) concentrations than the AA or AG genotype carriers. Serum total cholesterol concentrations were significantly higher in healthy women with the PvuII CC genotype than in those with the TT or TC genotypes, whereas healthy women with the GG genotype of the ESR1 XbaI polymorphism had significantly higher serum total cholesterol and LDL cholesterol levels compared to those with the AA or AG genotypes. No other effects of the ESR1 PvuII and XbaI polymorphisms were found on the investigated lipid, haemostatic and inflammatory variables either in the total group or in women and men separately.CONCLUSIONS:The ESR1 PvuII and XbaI gene polymorphisms seem to affect lipoprotein metabolism in healthy subjects of peak reproductive age. However, further studies are needed to determine the molecular mechanisms by which the two polymorphisms could influence serum lipid levels.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
lipid
estrogen receptor
inflammatory
gene
polymorphism
Megjelenés:Clinica Chimica Acta. - 380 : 1-2 (2007), p. 157-164. -
További szerzők:Nagy Bálint (1956-) (molekuláris genetikus) Kovács Margit (belgyógyász, Budapest) Walentin Szilvia Imreh Éva Rigó János (1958-) (szülész-nőgyógyász) Szalay János Füst György (Budapest) Prohászka Zoltán Karádi István (1952-) (belgyógyász, kardiológus)
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6.

001-es BibID:BIBFORM065317
Első szerző:Molvarec Attila (szülész-nőgyógyász)
Cím:Serum heat shock protein 70 levels are decreased in normal human pregnancy / Molvarec Attila, Rigó János, Nagy Bálint, Walentin Szilvia, Szalay János, Füst George, Karádi István, Prohászka Zoltán
Dátum:2007
ISSN:0165-0378
Megjegyzések:Heat shock proteins (Hsps) are primarily known to be intracellular proteins with molecular chaperone and cytoprotective functions. However, Hsp60 and Hsp70 have been found in the serum and plasma of healthy non-pregnant individuals. We aimed to compare serum Hsp70 concentrations in healthy pregnant women with those of healthy non-pregnant women and to determine factors influencing serum Hsp70 levels in normal pregnancy. One hundred and seventy six healthy pregnant women with uncomplicated pregnancies (age, 17-44 years; gestational age, 20-41 weeks) and 81 healthy, age-matched non-pregnant women (age, 22-40 years) were enrolled in this cross-sectional study. Serum Hsp70 concentrations were measured using an enzyme-linked immunosorbent assay, and were significantly lower in healthy pregnant women than in healthy non-pregnant women (median (25-75 percentile): 0.29 (0.20-0.35)ng/ml versus 1.27 (0.86-1.72)ng/ml; p<0.001). In healthy pregnant women, there was a statistically significant negative correlation between maternal age and serum Hsp70 concentration (Spearman R=-0.35; p<0.001) and a significant positive correlation between gestational age and serum Hsp70 level (Spearman R=0.35; p<0.001). The capacity of extracellular Hsp70 to elicit innate and adaptive proinflammatory immune responses might be harmful in pregnancy and lead to immune rejection of the fetal semi-allograft. We hypothesize that decreased circulating Hsp70 levels are due to unknown regulatory mechanisms aimed at maintaining immune tolerance in pregnancy. In conclusion, serum Hsp70 concentrations are decreased in normal human pregnancy; however, further studies are needed to explain the observed differences between pregnant and non-pregnant women.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
serum
heat
schock
protein-70
decreased
Megjelenés:Journal Of Reproductive Immunology. - 74 : 1-2 (2007), p. 163-169. -
További szerzők:Rigó János (1958-) (szülész-nőgyógyász) Nagy Bálint (1956-) (molekuláris genetikus) Walentin Szilvia Szalay János Füst György (Budapest) Karádi István (1952-) (belgyógyász, kardiológus) Prohászka Zoltán
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7.

001-es BibID:BIBFORM065320
Első szerző:Molvarec Attila (szülész-nőgyógyász)
Cím:Association of increased serum heat shock protein 70 and C-reactive protein concentrations and decreased serum [alfa]2-HS glycoprotein concentration with the syndrome of hemolysis, elevated liver enzymes, and low platelet count / Molvarec Attila, Prohászka Zoltán, Nagy Bálint, Kalabay László, Szalay János, Füst Georg, Karádi István, Rigó János
Dátum:2007
ISSN:0165-0378
Megjegyzések:The primary aim of this study was to determine serum Hsp70 concentrations in HELLP syndrome. We measured also the serum concentrations of three acute phase proteins: C-reactive protein (CRP), alpha(2)-macroglobulin (AMG) and alpha(2)-HS glycoprotein (AHSG). Ten severe preeclamptic patients with HELLP syndrome, 20 severe preeclamptic patients without HELLP syndrome and 20 normotensive, healthy pregnant women were included in this case-control study. Serum concentrations of Hsp70, CRP, AMG and AHSG were measured using an enzyme-linked immunosorbent assay (Hsp70), particle-enhanced immunoturbidimetric assay (CRP) and radial immunodiffusion (AMG, AHSG). The serum Hsp70 and CRP concentrations were significantly higher, whereas the serum AHSG concentration was significantly lower in the HELLP group (H) than the severe preeclamptic (P) and control (C) groups (median (25-75 percentile); Hsp70: 2.02 ng/ml (0.76-2.23) (H) versus 0.54 ng/ml (0.47-0.79) (P), p<0.01, and 0.30 ng/ml (0.27-0.33) (C), p<0.001; CRP: 43.9 mg/l (27.1-84.5) (H) versus 6.5 mg/l (2.7-10.7) (P), p<0.001, and 2.5 mg/l (1.1-6.7) (C), p<0.001; AHSG: 588 microg/ml (492-660) (H) versus 654 microg/ml (576-768) (P), p<0.05, and 738 microg/ml (666-804) (C), p<0.01, respectively). The serum AMG concentration did not differ between the study groups. In the HELLP group, there was a statistically significant negative correlation between serum Hsp70 concentration and platelet count (Spearman R=-0.69, p=0.026). In conclusion, serum Hsp70 and CRP concentrations are increased, whereas serum AHSG concentration is decreased, in HELLP syndrome. The maternal systemic inflammation seems to be more pronounced in HELLP syndrome than preeclampsia without HELLP syndrome, as suggested by the alterations in serum CRP and AHSG levels. However, it requires further investigation to determine whether these changes are causes or consequences of the disease.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
serum
heat
schock
protein-70
C-reactive
Megjelenés:Journal Of Reproductive Immunology. - 73 : 2 (2007), p. 172-179. -
További szerzők:Prohászka Zoltán Nagy Bálint (1956-) (molekuláris genetikus) Kalabay László Szalay János Füst György (Budapest) Karádi István (1952-) (belgyógyász, kardiológus) Rigó János (1928-) (sebész, ortopéd traumatológus)
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Intézményi repozitóriumban (DEA) tárolt változat
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8.

001-es BibID:BIBFORM065322
Első szerző:Molvarec Attila (szülész-nőgyógyász)
Cím:Association of elevated serum heat-shock protein 70 concentration with transient hypertension of pregnancy, preeclampsia and superimposed preeclampsia : a case-control study / A. Molvarec, Z. Prohászka, B. Nagy, J. Szalay, G. Füst, I. Karádi, J. Rigó Jr.
Dátum:2006
ISSN:0950-9240
Megjegyzések:Our aim was to investigate the association between serum heat-shock protein (Hsp) 70 concentration and hypertensive disorders of pregnancy. One hundred and forty-two pregnant women with hypertensive disorders (93 with preeclampsia, 29 with transient hypertension of pregnancy and 20 with superimposed preeclampsia) and 127 normotensive, healthy pregnant women were included in the study. Serum Hsp70 concentration was measured using enzyme-linked immunosorbent assay. The serum Hsp70 concentration was significantly higher in patients with transient hypertension of pregnancy, in preeclamptic patients and in patients with superimposed preeclampsia than in the control group (median (25-75 percentile): 0.66 (0.52-0.84), 0.55 (0.42-0.80), 0.61 (0.42-0.91) ng/ml vs 0.31 (0.27-0.39) ng/ml, respectively; P<0.001). Multivariate logistic regression analysis showed independent association of elevated serum Hsp70 level with transient hypertension of pregnancy, preeclampsia and superimposed preeclampsia. The difference in serum Hsp70 concentration between preeclamptic patients and the control group was statistically significant in each gestational age category. In the groups of preeclamptic and superimposed preeclamptic patients, there was no significant difference in serum Hsp70 concentration between mild and severe preeclamptic patients, between patients with late and early onset of the disease, as well as between preeclamptic patients without and with foetal growth restriction. In conclusion, serum Hsp70 concentration is elevated in transient hypertension of pregnancy, in preeclampsia and in superimposed preeclampsia. Circulating Hsp70 may not only be a marker for these conditions, but might also play a role in their pathogenesis. However, further studies are needed to explore its role in the pathogenesis of hypertensive disorders of pregnancy.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
serum
heat schock
protein-70
pregnancy
Megjelenés:Journal Of Human Hypertension. - 20 : 10 (2006), p. 780-786. -
További szerzők:Prohászka Zoltán Nagy Bálint (1956-) (molekuláris genetikus) Szalay Judit Füst György (Budapest) Karádi István (1952-) (belgyógyász, kardiológus) Rigó János (1958-) (szülész-nőgyógyász)
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Intézményi repozitóriumban (DEA) tárolt változat
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9.

001-es BibID:BIBFORM074807
Első szerző:Nagy Bálint (molekuláris genetikus)
Cím:Apolipoprotein E alleles in women with severe pre-eclampsia / B. Nagy, J. Rigó Jr., L. Fintor, I. Karádi, T. Tóth
Dátum:1998
ISSN:0021-9746
Megjegyzések:This study investigated the frequency of apolipoprotein E (apoE) alleles among women with severe pre-eclampsia. The presence of the three most common apoE alleles (epsilon 2, epsilon 3, epsilon 4) was determined by polymerase chain reaction-restriction fragment length polymorphism in three groups of white women: non-pregnant healthy (n = 101), pregnant healthy (n = 52), and pregnant with a diagnosis of severe pre-eclampsia (n = 54). The frequency of apo epsilon 2 was highest among women with severe pre-eclampsia (16.6%) followed by non-pregnant women (12.9%), and those experiencing a healthy pregnancy (10.6%). The higher frequency of the apo epsilon 2 allele detected among women with severe pre-eclampsia suggests that apoE may play a role in the development of pre-eclampsia.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
apolipoprotein E
pre-eclampsia
alleles
Megjelenés:Journal of Clinical Pathology. - 51 : 4 (1998), p. 324-325. -
További szerzők:Rigó János (1958-) (szülész-nőgyógyász) Fintor, Lou Karádi István (1952-) (belgyógyász, kardiológus) Tóth T.
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10.

001-es BibID:BIBFORM074862
Első szerző:Nagy Bálint (molekuláris genetikus)
Cím:Distribution of apolipoprotein(a) isoforms in normotensive and severe preeclamptic women / Bálint Nagy, János Rigó Jr., Lou Fintor, László Romics, Zoltán Papp, István Karádi
Dátum:1999
ISSN:1057-0802
Megjegyzések:OBJECTIVE:Preeclampsia is a pregnancy-related disorder constituting one of the primary causes of worldwide maternal and fetal mortality, but despite intensive research its pathogenesis remains unclear. Lipids have been implicated in the development of preeclampsia, although this possible association remains controversial and not yet fully investigated. This study set out to examine the potential association between lipoprotein(a) and the development of severe preeclampsia. The focus of this study was to investigate the potential utility of apolipoprotein(a) isoforms as possible diagnostic markers for identifying women at risk for developing preeclampsia.METHODS:Study participants included a control group of nonpregnant female volunteers (n = 59), a group of healthy pregnant (normotensive) female volunteers (n = 51), and a group of severe preeclamptic female volunteers (n = 59). Serum lipoprotein(a) concentrations were measured using double-antibody ELISA methods and were found to be 17.0+/-23.6 mg/dl among nonpregnant controls (n = 51), 15.9+/-15.8 mg/dl among healthy pregnant normotensives (n = 51), and 16.2+/-16.7 mg/dl in the preeclamptic group (n = 59). In addition, apolipoprotein (a) isoforms were identified using high-resolution SDS-agarose electrophoresis followed by immunoblotting.RESULTS:We detected no significant differences between the groups studied in the distribution of isoforms (Chi-square = 1.21, df = 4, P = 0.89); however, in a 1-week interval we detected a 42.2% rise in Lp(a) levels as well as a 67.1% rise in C-reactive protein concentrations among 10 volunteers in the preeclamptic group (median = 9.6; P < 0.05).CONCLUSIONS:Although the exact mechanism of pathogenesis continues to elude investigators, our results suggest that lipoprotein(a) may act as an acute-phase reactant during preeclampsia. Although our results are preliminary, they are consistent with growing evidence implicating lipids as among those factors involved in the etiology of preeclampsia. Changes in apolipoprotein(a) may be among those important biochemical markers that are found to be useful in the early identification of high-risk women and warrant further study.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
apolipoprotein a
isoforms
preeclampsia
Megjelenés:Journal of Maternal-Fetal Medicine. - 8 : 6 (1999), p. 270-274. -
További szerzők:Rigó János (1958-) (szülész-nőgyógyász) Fintor, Lou Romics László Papp Zoltán (1942-) (szülész-nőgyógyász, genetikus) Karádi István (1952-) (belgyógyász, kardiológus)
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DOI
Intézményi repozitóriumban (DEA) tárolt változat
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11.

001-es BibID:BIBFORM065360
Első szerző:Nagy Bálint (molekuláris genetikus)
Cím:Apolipoprotein E gene polymorphism frequencies in a sample of healthy Hungarians / Balint Nagy, Istvan Karadi, Lou Fintor, Janos Rigo Jr., Laszlo Romics, Zoltan Papp
Dátum:1999
ISSN:0009-8981
Megjegyzések:Apolipoprotein E (apo E) has been found to play an important role in lipid metabolism and has been associated with cardiovascular and neurodegenerative conditions. Hungarians have some of the highest rates of cardiovascular morbidity and mortality in the world. This study examines the distribution of apo E alleles and genotypes in a population of healthy ethnic Hungarian blood donors (n = 302). Male (n = 152) and female (n = 150) subjects ranging from 18 to 62 years of age (mean 37.0) were involved. To determine the frequency of apo E alleles, polymerase chain reaction followed by restriction length polymorphism was applied. The analyses of data showed that apo E allele epsilon3 had the greatest frequency in this group (0.807), followed by apo epsilon2 (0.104) and apo epsilon4 (0.087). The highest genotype frequency was found to be epsilon3/3 at 65.2% (n = 197) followed by genotype epsilon3/4 at 15.9% (n = 48), genotype epsilon2/3 at 15.2% (n = 46), genotype epsilon2/2 at 2.3% (n = 7), genotype epsilon2/4 at 1.0% (n = 3) and genotype epsilon4/4 at 0.4% (n = 1). The apo E frequencies found in this study appear to differ from an earlier study of blood donors, where the results are based on apo E phenotyping.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
apolipoprotein
E
gene
polymorphism
Hungarians
Megjelenés:Clinica Chimica Acta. - 282 (1999), p. 147-150. -
További szerzők:Karádi István (1952-) (belgyógyász, kardiológus) Fintor, Lou Rigó János (1958-) (szülész-nőgyógyász) Romics László Papp Zoltán (1942-) (szülész-nőgyógyász, genetikus)
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Intézményi repozitóriumban (DEA) tárolt változat
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12.

001-es BibID:BIBFORM065362
Első szerző:Nagy Bálint (molekuláris genetikus)
Cím:Detection of factor V Leiden mutation in severe pre-eclamptic Hungarian women / Balint Nagy, Tamas Tóth, Janos Rigó Jr., Istvan Karadi, Laszlo Romics, Zoltan Papp
Dátum:1998
ISSN:0009-9163
Megjegyzések:Pre-eclampsia is a pregnancy-related disorder that complicates approximately 5% of all pregnancies and is cited as the primary cause of worldwide maternal and fetal mortality. The factor V Leiden mutation has been implicated in the development of severe pre-eclampsia. In order to investigate this association, a sample of 198 Hungarian women was recruited and enrolled in one of the three groups based on reproductive and health status: those as classified as pregnant and healthy (n = 71), those diagnosed as pregnant and severe pre-eclamptic (n = 69), and those found to be healthy and non-pregnant (n = 58). The presence of factor V Leiden mutation was determined by using polymerase chain reaction (PCR) followed by restriction fragment length polymorphism analysis (RFLP). We identified three (5.2%) heterozygous among healthy non-pregnant participants, five (7.0%) heterozygous among healthy pregnant participants and 13 (18.8%) heterozygous among pre-eclamptic women (p < 0.05, 95% CI). Our result supports the previous observation that carriers of factor V Leiden mutation are at increased risk for developing severe pre-eclampsia.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
factor V
Leiden
mutation
pre-eclamptic
Hungarian
Megjelenés:Clinical Genetics. - 53 : 6 (1998), p. 478-481. -
További szerzők:Tóth Tamás (gyermekgyógyász) Rigó János (1958-) (szülész-nőgyógyász) Karádi István (1952-) (belgyógyász, kardiológus) Romics László Papp Zoltán (1942-) (szülész-nőgyógyász, genetikus)
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Intézményi repozitóriumban (DEA) tárolt változat
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