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001-es BibID:BIBFORM074862
Első szerző:Nagy Bálint (molekuláris genetikus)
Cím:Distribution of apolipoprotein(a) isoforms in normotensive and severe preeclamptic women / Bálint Nagy, János Rigó Jr., Lou Fintor, László Romics, Zoltán Papp, István Karádi
Dátum:1999
ISSN:1057-0802
Megjegyzések:OBJECTIVE:Preeclampsia is a pregnancy-related disorder constituting one of the primary causes of worldwide maternal and fetal mortality, but despite intensive research its pathogenesis remains unclear. Lipids have been implicated in the development of preeclampsia, although this possible association remains controversial and not yet fully investigated. This study set out to examine the potential association between lipoprotein(a) and the development of severe preeclampsia. The focus of this study was to investigate the potential utility of apolipoprotein(a) isoforms as possible diagnostic markers for identifying women at risk for developing preeclampsia.METHODS:Study participants included a control group of nonpregnant female volunteers (n = 59), a group of healthy pregnant (normotensive) female volunteers (n = 51), and a group of severe preeclamptic female volunteers (n = 59). Serum lipoprotein(a) concentrations were measured using double-antibody ELISA methods and were found to be 17.0+/-23.6 mg/dl among nonpregnant controls (n = 51), 15.9+/-15.8 mg/dl among healthy pregnant normotensives (n = 51), and 16.2+/-16.7 mg/dl in the preeclamptic group (n = 59). In addition, apolipoprotein (a) isoforms were identified using high-resolution SDS-agarose electrophoresis followed by immunoblotting.RESULTS:We detected no significant differences between the groups studied in the distribution of isoforms (Chi-square = 1.21, df = 4, P = 0.89); however, in a 1-week interval we detected a 42.2% rise in Lp(a) levels as well as a 67.1% rise in C-reactive protein concentrations among 10 volunteers in the preeclamptic group (median = 9.6; P < 0.05).CONCLUSIONS:Although the exact mechanism of pathogenesis continues to elude investigators, our results suggest that lipoprotein(a) may act as an acute-phase reactant during preeclampsia. Although our results are preliminary, they are consistent with growing evidence implicating lipids as among those factors involved in the etiology of preeclampsia. Changes in apolipoprotein(a) may be among those important biochemical markers that are found to be useful in the early identification of high-risk women and warrant further study.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
apolipoprotein a
isoforms
preeclampsia
Megjelenés:Journal of Maternal-Fetal Medicine. - 8 : 6 (1999), p. 270-274. -
További szerzők:Rigó János (1958-) (szülész-nőgyógyász) Fintor, Lou Romics László Papp Zoltán (1942-) (szülész-nőgyógyász, genetikus) Karádi István (1952-) (belgyógyász, kardiológus)
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2.

001-es BibID:BIBFORM065360
Első szerző:Nagy Bálint (molekuláris genetikus)
Cím:Apolipoprotein E gene polymorphism frequencies in a sample of healthy Hungarians / Balint Nagy, Istvan Karadi, Lou Fintor, Janos Rigo Jr., Laszlo Romics, Zoltan Papp
Dátum:1999
ISSN:0009-8981
Megjegyzések:Apolipoprotein E (apo E) has been found to play an important role in lipid metabolism and has been associated with cardiovascular and neurodegenerative conditions. Hungarians have some of the highest rates of cardiovascular morbidity and mortality in the world. This study examines the distribution of apo E alleles and genotypes in a population of healthy ethnic Hungarian blood donors (n = 302). Male (n = 152) and female (n = 150) subjects ranging from 18 to 62 years of age (mean 37.0) were involved. To determine the frequency of apo E alleles, polymerase chain reaction followed by restriction length polymorphism was applied. The analyses of data showed that apo E allele epsilon3 had the greatest frequency in this group (0.807), followed by apo epsilon2 (0.104) and apo epsilon4 (0.087). The highest genotype frequency was found to be epsilon3/3 at 65.2% (n = 197) followed by genotype epsilon3/4 at 15.9% (n = 48), genotype epsilon2/3 at 15.2% (n = 46), genotype epsilon2/2 at 2.3% (n = 7), genotype epsilon2/4 at 1.0% (n = 3) and genotype epsilon4/4 at 0.4% (n = 1). The apo E frequencies found in this study appear to differ from an earlier study of blood donors, where the results are based on apo E phenotyping.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
apolipoprotein
E
gene
polymorphism
Hungarians
Megjelenés:Clinica Chimica Acta. - 282 (1999), p. 147-150. -
További szerzők:Karádi István (1952-) (belgyógyász, kardiológus) Fintor, Lou Rigó János (1958-) (szülész-nőgyógyász) Romics László Papp Zoltán (1942-) (szülész-nőgyógyász, genetikus)
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3.

001-es BibID:BIBFORM065362
Első szerző:Nagy Bálint (molekuláris genetikus)
Cím:Detection of factor V Leiden mutation in severe pre-eclamptic Hungarian women / Balint Nagy, Tamas Tóth, Janos Rigó Jr., Istvan Karadi, Laszlo Romics, Zoltan Papp
Dátum:1998
ISSN:0009-9163
Megjegyzések:Pre-eclampsia is a pregnancy-related disorder that complicates approximately 5% of all pregnancies and is cited as the primary cause of worldwide maternal and fetal mortality. The factor V Leiden mutation has been implicated in the development of severe pre-eclampsia. In order to investigate this association, a sample of 198 Hungarian women was recruited and enrolled in one of the three groups based on reproductive and health status: those as classified as pregnant and healthy (n = 71), those diagnosed as pregnant and severe pre-eclamptic (n = 69), and those found to be healthy and non-pregnant (n = 58). The presence of factor V Leiden mutation was determined by using polymerase chain reaction (PCR) followed by restriction fragment length polymorphism analysis (RFLP). We identified three (5.2%) heterozygous among healthy non-pregnant participants, five (7.0%) heterozygous among healthy pregnant participants and 13 (18.8%) heterozygous among pre-eclamptic women (p < 0.05, 95% CI). Our result supports the previous observation that carriers of factor V Leiden mutation are at increased risk for developing severe pre-eclampsia.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
factor V
Leiden
mutation
pre-eclamptic
Hungarian
Megjelenés:Clinical Genetics. - 53 : 6 (1998), p. 478-481. -
További szerzők:Tóth Tamás (gyermekgyógyász) Rigó János (1958-) (szülész-nőgyógyász) Karádi István (1952-) (belgyógyász, kardiológus) Romics László Papp Zoltán (1942-) (szülész-nőgyógyász, genetikus)
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4.

001-es BibID:BIBFORM065319
Első szerző:Vallus Gábor (érsebész)
Cím:Factor V Leiden and apolipoprotein E genotypes in severe femoropopliteal atherosclerosis with restenosis / Gábor Vallus, Béla Dlustus, György Acsády, Zoltán Papp, Judit Skopál, Zoltán Nagy, Zoltán Prohászka, László Romics, István Karádi, Bálint Nagy
Dátum:2007
ISSN:0009-8981
Megjegyzések:BACKGROUND:The role of factor V (Leiden) mutation, thrombophilia, and apolipoprotein E (apoE) alleles in the pathogenesis of accelerated atherosclerosis and restenosis was studied in patients requiring reoperation within five years after femoropopliteal angioplasty with artificial grafts.METHODS:One hundred ninety-eight consecutive patients with femoropopliteal atherosclerotic disease, reoperated for restenosis were contacted by phone and 100 of them returned for laboratory and clinical work-up. In addition to clinical evaluation and routine laboratory investigations, parameters of lipoprotein metabolism, factor V (Leiden) mutation and apolipoprotein E (apoE) allele were studied by PCR amplification of DNA and endonuclease digestion techniques.RESULTS:A significantly higher incidence of factor V (Leiden) mutation was found in patients with atherosclerosis and restenosis, compared to 445 healthy blood donors (13/200, 6.5% vs. 34/890, 3.8%, p=0.0379). Distribution of the alleles of the apolipoprotein E (apoE) gene was different, when the patients were compared to 372 controls; however, the difference only approached the level of statistical significance (25/200, 12.5% vs. 56/744, 7.5%, p=0.0515). Comparing the two groups, the number of epsilon4 allele carriers was significantly higher among patients with restenosis (25/100, 25% vs. 53/272, 14%, p=0.0147).CONCLUSION:Factor V (Leiden) mutation may influence the progression of atherosclerosis and the development of restenosis after revascularization in patients with accelerated femoropopliteal atherosclerosis. Further investigation is needed whether long-term anticoagulation has an impact or not on the course of disease in such cases. ApoE epsilon4 allele should be screened in patients with femoropopliteal atherosclerosis, because it indicates a faster progression of atherosclerosis and may predict restenosis after revascularization procedure.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Factor V
Leiden mutation
apolipoprotein E
genotypes
femoropopliteal
atherosclerosis
Megjelenés:Clinica Chimica Acta. - 377 : 1-2 (2007), p. 256-260. -
További szerzők:Dlustus Béla (1945-) (érsebész) Acsády György Papp Zoltán (1942-) (szülész-nőgyógyász, genetikus) Skopál Judit Nagy Zoltán Prohászka Zoltán Romics László Karádi István (1952-) (belgyógyász, kardiológus) Nagy Bálint (1956-) (molekuláris genetikus)
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