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1.

001-es BibID:BIBFORM065213
Első szerző:Lasabova, Zora
Cím:Association of specific diplotypes defined by common rs1800682 and rare rs34995925 single nucleotide polymorphisms within the STAT1 transcription binding site of the FAS gene promoter with preeclampsia / Zora Lasabova, Imrich Zigo, Iveta Svecova, Gabor Szabo, Andrea Stanclova, Maria Skerenova, Pavol Zubor, Kristina Biskupska-Bodova, Janos Rigo, Balint Nagy, Jan Danko
Dátum:2014
ISSN:1338-4325
Megjegyzések:The tolerance of fetal antigens by intradecidual T-cell involving the Fas-mediated apoptosis plays an important role in the physiological course of pregnancy. Objective of this study is to determine the association of diplotypes of common rs1800682 G and rare rs34995925 C alleles within the STAT1 transcription binding site of the FAS promoter region with preeclampsia. There were 116 preeclamptic women and 123 healthy control subjects from Hungary and Slovakia enrolled in the study. The presence of the GG or GA genotypes on rs1800682 was confirmed in 91 patients and 85 controls (OR = 1.628, 95% CI 0.907?2.92). The rare rs34995925 C allele laying 7 bp further from rs1800682 within STAT1 transcription binding site was detected in 3 preeclamptic cases and none healthy subjects. Haplotypes GT and AC were defined by common rs1800682 G and rare rs34995925C alleles, respectively, and were considered as "low" FAS-producing. The combinationsof GT or AC with normal FAS-producing haplotypes AT were considered as "low" FAS-producing diplotypes in dominant model. The "low"FAS-producing diplotype group of GT/GT, GT/AT, and AC/AT compared to the normal FAS-producing diplotype group of AT/AT showed OR = 1.91 (95% CI 1.04?3.48) and p= 0.03 for the association with preeclampsia.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Preeclampsia
FAS promoter region
dyplotypes
Megjelenés:General physiology and biophysics. - 33 : 02 (2014), p. 199-204. -
További szerzők:Zigo, Imrich Svecova, Iveta Szabó Gábor (budapesti orvos) Stanclova, Andrea Skerenova, Maria Zubor, Pavol Biskupska-Bodova, Kristina Rigó János (1958-) (szülész-nőgyógyász) Nagy Bálint (1956-) (molekuláris genetikus) Danko, Jan
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2.

001-es BibID:BIBFORM075327
Első szerző:Szabó Gábor (budapesti orvos)
Cím:Increased B-type natriuretic peptide levels in early-onset versus late-onset preeclampsia / Szabó Gábor, Molvarec Attila, Nagy Bálint, Rigó János Jr.
Dátum:2013
ISSN:1434-6621
Megjegyzések:Background: We compared B-type natriuretic peptide (BNP) levels, clinical and laboratory findings in early-onset preeclampsia (EOP), late-onset preeclampsia (LOP) and healthy pregnant groups. Methods: We studied 40 healthy pregnant and 40 preeclamptic patients. Preeclamptics were divided in two groups, the EOP group (n=20) and LOP group (n=20), according to gestational age at the onset of disease. The distinction criterion for early- vs. late-onset was set as week 34 of gestation. The concentration of the BNP levels was measured by a sandwich fluorescence immunoassay. For statistical analysis of the clinical and laboratory findings non-parametric methods were applied. Results: BNP levels were higher in EOP [61.35 (36.95?93.25) pg/mL] and LOP patients [32.4 (19.15?39.2) pg/mL] than in healthy pregnant women [10.05 (6.08?16.03) pg/mL] (both p<0.001). Furthermore, EOPs had significantly higher BNP levels as compared to LOP patients (p<0.001). A BNP cut-off <24.5 pg/mL had a negative-predictive value of 85.1% excluding preeclampsia. There was a significant inverse correlation between plasma BNP levels of EOP patients and sodium (p<0.05) and total protein concentrations (p<0.05). In the EOP group, a significant positive correlation was observed between plasma levels of BNP and hematocrit (p<0.05), serum potassium (p<0.05), urea (p<0.05) and 24-h proteinuria (p<0.05). Conclusions: BNP levels were significantly higher in EOP than in LOP patients. The cut-off value <24.5 pg/mL seems to be a powerful discriminative indicator excluding preeclampsia. The amount of proteinuria and total protein levels correlate with the elevation of the BNP levels. In EOP the extent of proteinuria is higher than in the LOP.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
natriuretic peptide
preeclampsia
B-type
increased
Megjelenés:Clinical Chemistry And Laboratory Medicine. - 52 : 2 (2013), p. 1-8. -
További szerzők:Molvarec Attila (szülész-nőgyógyász) Nagy Bálint (1956-) (molekuláris genetikus) Rigó János (1958-) (szülész-nőgyógyász)
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3.

001-es BibID:BIBFORM065228
Első szerző:Szabó Gábor (budapesti orvos)
Cím:Natriuretic peptide precursor B gene (TTTC)n microsatellite polymorphism in pre-eclampsia / Gábor Szabó, Attila Molvarec, Balázs Stenczer, János Rigó Jr., Bálint Nagy
Dátum:2011
ISSN:0009-8981
Megjegyzések:There is a variable tandem repeat polymorphism in the 5·-flanking region of the natriuretic peptide precursor B gene (NPPB). A previous study showed association of the (TTTC) small tandem repeat (STR) variants of this gene and essential hypertension. Our aim was to identify this polymorphism in samples of pre-eclamptic patients and healthy controls. We also compared the natriuretic peptide B (BNP) concentrations.MethodsBlood samples were collected from healthy pregnant normotensive women (n = 235) and women with pre-eclampsia (n = 220). DNA was isolated and fluorescent PCR and DNA fragment analysis was performed for the detection of (TTTC) repeats. The plasma BNP concentration was measured by fluorescence immunoassay method.ResultsWe detected 12 different (TTTC) repeats on the NPPB gene in the studied population. The overall distribution of alleles and genotypes was significantly different between the control and pre-eclamptic groups. The number of 10-repeat genotype carriers showed significantly lower frequency in pre-eclamptics than in the healthy pregnant controls (p = 0.032). After adjustment for confounding factors pre-pregnancy BMI, maternal age, primiparity and smoking, the calculated odds ratio (OR) was 0.19 (95% CI: 0.04?0.87). Similarly, the 12-repeat genotype carriers showed significantly lower frequency in pre-eclamptics than in the healthy pregnants (p = 0.037; adjusted OR: 0.53 (95% CI: 0.29?0.96)). In contrast the 11-repeat genotype carrier frequency was significantly higher in the pre-eclamptic than in the healthy pregnant group (p < 0.001; adjusted OR 2.91 (95% CI: 1.75?4.84)).The concentration of the BNP was 9.75 pg/ml in the healthy controls and 32.40 pg/ml in the pre-eclamptic group (p < 0.0001). The 11/11 genotype carriers had significantly higher BNP levels in both groups.ConclusionsThe NPPB gene (TTTC) microsatellite polymorphism in the 5·-flanking region showed significant difference in the distribution of alleles and genotypes between healthy pregnant controls and pre-eclamptic patients in an ethnically homogeneous population. The concentration of the BNP was higher in pre-eclamptic women, and it showed association with the (TTTC) genotypes. We introduced an F-PCR and DNA fragment analysis method for the fast and reliable detection of this STR.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Natriuretikus
Peptide
B type
Polymorphism
Megjelenés:Clinica Chimica Acta 412 (2011), p. 1371-1375. -
További szerzők:Molvarec Attila (szülész-nőgyógyász) Stenczer Balázs Rigó János (1958-) (szülész-nőgyógyász) Nagy Bálint (1956-) (molekuláris genetikus)
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Intézményi repozitóriumban (DEA) tárolt változat
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4.

001-es BibID:BIBFORM065227
Első szerző:Szabó Gábor (budapesti orvos)
Cím:Letter to the Editor : corrections to the natriuretic peptide article in Journal of Cardiology / Szabó Gabor, Nagy Balint
Dátum:2012
ISSN:0914-5087
Megjegyzések:We read the article of Nishikimi et al. with great interest [1] on "Current biochemistry, molecular biology, and clinical relevance of natriuretic peptides." The content of the article is very interesting and nicely collected, but we found a few mistakes and we would like to call your attention to these.1. Page 132. BNP section, line 14. "Exon 3 encodes the terminal tyrosine and the 3· untranslated region," correctly it is histidine as the authors show correctly in Fig. 1.2. Page 133. Fig. 2. It says corin cuts the proANP 26?151 (proANP 1?126) to Nt proANP and ?ANP. This takes place at Arg?Arg bond (98?99). If we use what the authors state (26?124 and 125?151) this Arg?Arg is located at 99?100, so the ?ANP has only 27 amino acids. While the correct numbering is 26?123 and 124?151 so the ?ANP has the correct 28 amino acids with the cutting place at 98?99 [2].3. Page 134. Fig. 4. According to the figure by cutting the proCNP to CNP (cleaving enzymes PC2 and/or PC1/3) we are receiving the active CNP which consists of 22 amino acids, while based on the figure we are having the molecule which consists only of 21 amino acids, so the correct numbers are not 106?126 (21), rather 105?126 (22).These are small details but we should use the correct data to give exact information to the readers.
Tárgyszavak:Orvostudományok Klinikai orvostudományok levél
natriuretec peptid
B type
Megjelenés:Journal of Cardiology 59 : 1 (2012), p. 97-97. -
További szerzők:Nagy Bálint (1956-) (molekuláris genetikus)
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5.

001-es BibID:BIBFORM065316
Első szerző:Sziller István (szülész-nőgyógyász szakorvos)
Cím:Mannose-binding lectin (MBL) codon 54 gene polymorphism protects against development of pre-eclampsia, HELLP syndrome and pre-eclampsia-associated intrauterine growth restriction / Sziller I., Babula O., Hupuczi P., Nagy B., Rigo B., Szabo G., Papp Z., Linhares I.M., Witkin S. S.
Dátum:2007
ISSN:1360-9947
Megjegyzések:Insufficient invasion of the spiral arteries by trophoblast cells is associated with the etiology of pre-eclampsia, the syndrome of hemolysis, elevated liver enzymes and low platelet counts (HELLP) and pre-eclampsia-associated intrauterine growth restriction (IUGR). Mannose-binding lectin (MBL) is a component of the innate immune system. MBL-mediated activation of the complement cascade is an important event in the destruction of invading trophoblasts. The gene coding for MBL is polymorphic, and variant alleles result in greatly reduced circulating MBL levels. The aim of this study was to test the association between an MBL polymorphism and pre-eclampsia, HELLP syndrome and IUGR. DNA was extracted from buccal swabs of 51 women with pre-eclampsia, 81 women with HELLP syndrome and 184 healthy pregnant controls. Aliquots were tested for a single nucleotide MBL gene polymorphism at codon 54 by PCR and endonuclease digestion. Homozygosity for the wild-type allele was more frequent in patients with pre-eclampsia (P = 0.04) and HELLP syndrome (P = 0.02) when compared with controls. The presence of the variant allele was more prevalent among controls than in women with pre-eclampsia (P = 0.02) or HELLP syndrome (P = 0.028). Twenty-two (55%) patients with pre-eclampsia and 43 (53%) women with HELLP syndrome delivered an IUGR neonate. MBL-54 heterozygosity was more frequent in controls (27.2%) than in pre-eclamptic women (4.5%, P = 0.025) and those with HELLP syndrome (11.7%, P = 0.05) who delivered an IUGR neonate. Genotype frequencies of neonates born to mothers in all study groups were similar. Carriage of the MBL codon 54 polymorphism protects against pre-eclampsia, HELLP syndrome and IUGR and implies that an MBL-mediated event might be involved in the pathogenesis of these disorders.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
mannose-binding
lectin
codon54
gene
polymorphism
Megjelenés:Molecular Human Reproduction. - 13 : 4 (2007), p. 281-285. -
További szerzők:Babula, Oksana Hupuczi Petronella (anaesthesiológus) Nagy Bálint (1956-) (molekuláris genetikus) Rigó Barbara (szülész-nőgyógyász) Szabó Gábor (budapesti orvos) Papp Zoltán (1942-) (szülész-nőgyógyász, genetikus) Linhares, Iara Moreno Witkin, Steven Sol
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Intézményi repozitóriumban (DEA) tárolt változat
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6.

001-es BibID:BIBFORM065310
Első szerző:Than Nándor Gábor (szülész-nőgyógyász)
Cím:Placental Protein 13 (galectin-13) has decreased placental expression but increased shedding and maternal serum concentrations in patients presenting with preterm preeclampsia and HELLP syndrome / Nandor Gabor Than, Omar Abdul-Rahman, Rita Magenheim, Balint Nagy, Tibor Fule, Beata Hargitai, Marei Sammar, Petronella Hupuczi, Adi L. Tarca, Gabor Szabo, Ilona Kovalszky, Hamutal Meiri, Istvan Sziller, Janos Rigo Jr., Roberto Romero, Zoltan Papp
Dátum:2008
ISSN:0945-6317
Megjegyzések:Placental Protein 13 (PP13) is a galectin expressed by the syncytiotrophoblast. Women whosubsequently develop preterm preeclampsia have low first trimester maternal serum PP13concentrations. This study revealed that third trimester maternal serum PP13 concentration increasedwith gestational age in normal pregnancies (p<0.0001), and it was significantly higher in womenpresenting with preterm preeclampsia (p=0.02) and HELLP syndrome (p=0.01) than in pretermcontrols. Conversely, placental PP13 mRNA (p=0.03) and protein, as well as cytoplasmic PP13staining of the syncytiotrophoblast (p<0.05) was decreased in these pathological pregnanciescompared to controls. No differences in placental expression and serum concentrations of PP13 werefound at term between patients with preeclampsia and control women. In contrast, theimmunoreactivity of the syncytiotrophoblast microvillous membrane was stronger in both term andpreterm preeclampsia and HELLP syndrome than in controls. Moreover, large syncytial cytoplasmprotrusions, membrane blebs and shed microparticles strongly stained for PP13 in preeclampsia andHELLP syndrome. In conclusion, parallel to its decreased placental expression, an augmentedmembrane shedding of PP13 contributes to the increased third trimester maternal serum PP13concentrations in women with preterm preeclampsia and HELLP syndrome
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
placental
protein 13
galectin-13
expression
Megjelenés:Virchows Archiv. - 453 : 4 (2008), p. 387-400. -
További szerzők:Abdul-Rahman, Omar Magenheim Rita Nagy Bálint (1956-) (molekuláris genetikus) Füle Tibor Hargitai Beáta Sammar, Marei Hupuczi Petronella (anaesthesiológus) Tarca, Adi Laurentiu Szabó Gábor (budapesti orvos) Kovalszky Ilona Meiri, Hamutal Sziller István (szülész-nőgyógyász szakorvos) Rigó János (1958-) (szülész-nőgyógyász) Romero, Roberto Papp Zoltán (1942-) (szülész-nőgyógyász, genetikus)
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