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001-es BibID:	BIBFORM065297
Első szerző:	Molvarec Attila (szülész-nőgyógyász)
Cím:	Association between tumor necrosis factor (TNF)-α G-308A gene polymorphism and preeclampsia complicated by severe fetal growth restriction / Attila Molvarec, Ágnes Jermendy, Bálint Nagy, Margit Kovács, Tibor Várkonyi, Petronella Hupuczi, Zoltán Prohászka, János Rigó Jr.
Dátum:	2008
ISSN:	0009-8981
Megjegyzések:	Preeclampsia and HELLP (hemolysis, elevated liver enzymes, and low platelet count) syndrome are multifactorial disorders with genetic and environmental components. Given that the tumor necrosis factor (TNF)-alpha G-308A single nucleotide polymorphism (SNP) affects TNF-alpha gene transcription and that preeclampsia and HELLP syndrome are characterized by a shift towards a Th1-type maternal immune response with increased TNF-alpha production, the aim of the current study was to investigate whether this SNP is associated with preeclampsia and HELLP syndrome in a Caucasian population from Hungary. Additionally, we aimed to examine whether TNF-alpha G-308A polymorphism can influence the risk for fetal growth restriction in preeclamptic patients, which issue none of the earlier studies dealt with.METHODS:In a case-control study, we analyzed blood samples from 140 preeclamptic patients, 69 patients with HELLP syndrome and 144 normotensive, healthy pregnant women using the polymerase chain reaction (PCR)-restriction fragment length polymorphism (RFLP) method. We performed also a meta-analysis with our results and those of 8 previously published studies.RESULTS:There were no significant differences in the genotype and allele frequencies of the TNF-alpha G-308A polymorphism between preeclamptic patients and normotensive, healthy pregnant women. However, the mutant (TNF2 or A) allele occurred significantly more frequently in preeclamptic patients with IUGR than in those without IUGR (18.5% versus 7.1%, p=0.003). In addition, the frequency of the mutant allele carriers was significantly higher among preeclamptic patients with IUGR compared to those without IUGR (30.6% versus 12.8%, p=0.010). The mutant allele carriers were found to have an increased risk of severe IUGR-complicated preeclampsia, which was independent of maternal age, prepregnancy BMI and primiparity (odds ratio (OR): 2.89, 95% confidence interval (CI): 1.16-7.22, p=0.023; adjusted OR: 2.78, 95% CI: 1.04-7.45, p=0.042). Nevertheless, no significant differences were detected in the genotype and allele frequencies of the TNF-alpha G-308A polymorphism between patients with HELLP syndrome and control subjects. In the meta-analysis, no association was observed between this SNP and preeclampsia (summary OR: 0.956, 95% CI: 0.693-1.319).CONCLUSIONS:Although the meta-analysis demonstrated a lack of an overall association between TNF-alpha G-308A polymorphism and preeclampsia, our results suggest a role of this SNP in the risk of severe IUGR-complicated preeclampsia. However, further studies are required with a larger sample size to confirm our findings.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban Preeclampsia Gene Polymorphism TNF
Megjelenés:	Clinica Chimica Acta. - 392 : 1-2 (2008), p. 52-57. -
További szerzők:	Jermendy Ágnes Nagy Bálint (1956-) (molekuláris genetikus) Kovács Margit (belgyógyász, Budapest) Várkonyi Tibor Hupuczi Petronella (anaesthesiológus) Prohászka Zoltán Rigó János (1958-) (szülész-nőgyógyász)
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001-es BibID:	BIBFORM065315
Első szerző:	Molvarec Attila (szülész-nőgyógyász)
Cím:	Lipid, haemostatic and inflammatory variables in relation to the estrogen receptor [alfa] (ESR1) PvuII and XbaI gene polymorphisms / Molvarec Attila, Nagy Bálint, Kovács Margit, Walentin Szilvia, Imreh Éva, Rigó János Jr., Szalay János, Füst George, Prohászka Zoltán, Karádi István
Dátum:	2007
ISSN:	0009-8981
Megjegyzések:	Estrogen is known to affect lipoprotein metabolism, the haemostatic system and inflammatory markers. Our aim was to determine whether estrogen receptor alpha (ESR1) PvuII and XbaI gene polymorphisms can influence lipid, haemostatic and inflammatory variables in healthy Caucasian women and men of reproductive age.METHODS:58 healthy women (aged between 18 and 45 years) and 55 healthy men (aged between 21 and 45 years) of reproductive age were enrolled in our study. FSH levels, lipid (total cholesterol, triglyceride, HDL cholesterol, lipoprotein(a), apo A-I, apo B), haemostatic (prothrombin time, activated partial thromboplastin time (aPTT), thrombin time, fibrinogen, factor V, VII, VIII, protein C, protein S, antithrombin III) and inflammatory (CRP) variables were measured on autoanalyzers using commercially available kits. Serum VLDL and LDL cholesterol concentrations were calculated with the equation of Friedewald. The ESR1 PvuII and XbaI genotypes were determined with PCR-RFLP method.RESULTS:In the total group, the ESR1 XbaI GG genotype carriers had significantly higher serum lipoprotein(a) concentrations than the AA or AG genotype carriers. Serum total cholesterol concentrations were significantly higher in healthy women with the PvuII CC genotype than in those with the TT or TC genotypes, whereas healthy women with the GG genotype of the ESR1 XbaI polymorphism had significantly higher serum total cholesterol and LDL cholesterol levels compared to those with the AA or AG genotypes. No other effects of the ESR1 PvuII and XbaI polymorphisms were found on the investigated lipid, haemostatic and inflammatory variables either in the total group or in women and men separately.CONCLUSIONS:The ESR1 PvuII and XbaI gene polymorphisms seem to affect lipoprotein metabolism in healthy subjects of peak reproductive age. However, further studies are needed to determine the molecular mechanisms by which the two polymorphisms could influence serum lipid levels.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban lipid estrogen receptor inflammatory gene polymorphism
Megjelenés:	Clinica Chimica Acta. - 380 : 1-2 (2007), p. 157-164. -
További szerzők:	Nagy Bálint (1956-) (molekuláris genetikus) Kovács Margit (belgyógyász, Budapest) Walentin Szilvia Imreh Éva Rigó János (1958-) (szülész-nőgyógyász) Szalay János Füst György (Budapest) Prohászka Zoltán Karádi István (1952-) (belgyógyász, kardiológus)
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