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1.

001-es BibID:BIBFORM065356
Első szerző:Kalina Ákos
Cím:The association of serum lipoprotein(a) levels, apolipoprotein(a) size and (TTTTA)n polymorphism with coronary heart disease / Akos Kalina, Albert Csaszar, George Fust, Balint Nagy, Csaba Szalai, Istvan Karadi, Jeno Duba, Zoltan Prohaszka, Laura Horvath, Hans Dieplinger
Dátum:2001
ISSN:0009-8981
Megjegyzések:Background: The association between lipoprotein(a) levels, apolipoprotein(a) size and the (TTTTA)n polymorphism which is located in the 5· non-coding region of the apo(a) gene was studied in 263 patients with severe coronary heart disease and 97 healthy subjects. Methods: Lp(a) levels were measured by ELISA, apo(a) isoform size was determined by SDS?agarose gel electrophoresis, and analysis of the (TTTTA)n was carried out by PCR. For statistical calculation, both groups were divided into low (at least one apo(a) isoform with ?22 Kringle IV) and high (both isoforms with >22 KIV) apo(a) isoform sizes, and into low number (<10 in both alleles) and high number of (?10 at least one allele) TTTTA repeats. Results: Lp(a) levels were higher (P=0.007), apo(a) isoforms size ?22 KIV and TTTTA repeats ?10 were more frequent (P=0.007 and 0.01) in cases than in controls. Lp(a) levels were found to be increased with low apo(a) weight in both groups (both P<0.0001). In multivariate logistic regression analysis, only the Lp(a) levels (P=0.005) and (TTTTA)n polymorphism (P=0.002) were found to be significantly associated with CHD. Conclusion: Nevertheless, these results indicate that in CHD patients the (TTTTA)n polymorphism has an effect on Lp(a) levels which is independent of the apo(a) size.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
apolipoprotein(a)
(TTTTA)n
Polymorphism
serum
association
coronary
heart
diseases
Megjelenés:Clinica Chimica Acta. - 309 : 1 (2001), p. 45-51. -
További szerzők:Császár Albert Füst György (Budapest) Nagy Bálint (1956-) (molekuláris genetikus) Szalai Csaba Karádi István (1952-) (belgyógyász, kardiológus) Duba Jenő Prohászka Zoltán Horváth Laura Dieplinger, Hans
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2.

001-es BibID:BIBFORM065236
Első szerző:Lázár Levente (szülész-nőgyógyász)
Cím:Relationship of circulating cell-free DNA levels to cell-free fetal DNA levels, clinical characteristics and laboratory parameters in preeclampsia / Levente Lazar, János Rigó Jr., Bálint Nagy, Krisztián Balogh, Veronika Makó, László Cervenak, Miklós Mézes, Zoltán Prohászka, Attila Molvarec
Dátum:2009
ISSN:1471-2350
Megjegyzések:Background:The aim of our study was to examine whether increased circulating total cell-freeDNA levels are related to the clinical characteristics and standard laboratory parameters ofpreeclamptic patients, to markers of inflammation, endothelial activation or injury, oxidative stressand to cell-free fetal DNA levels.Methods:Circulating total cell-free DNA was measured by real-time quantitative PCR in plasmasamples obtained from 67 preeclamptic and 70 normotensive pregnant women. Standardlaboratory parameters, C-reactive protein, plasma von Willebrand factor antigen, plasmafibronectin, plasma malondialdehyde and cell-free fetal DNA levels were also determined.Results and Conclusion:Circulating total cell-free and fetal deoxyribonucleic acid levels weresignificantly elevated in pregnancies complicated by preeclampsia (median: 11.395 vs. 32.460 and0.001 vs. 0.086 pg/?l; P < .001). The quantity of plasma total cell-free DNA did not correlate with most of the laboratory parameters, except for serum aspartate aminotransferase and alanineaminotransferase activities (correlation coefficient: 0.31; P = 0.012 and 0.46; P < .001). There was no correlation with clinical characteristics, including body mass index. The releases of both free fetal and total cell-free deoxyribonucleic acid were found to be affected in preeclampsia.Hepatocellular necrosis seems to be responsible - at least partly - for increased circulating total DNA levels in preeclampsia, as suggested by the significant correlation with liver enzyme activities
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
cell free
DNA
Preeclampsia
clinical
Characteristics
Megjelenés:BMC Medical Genetics. - 10 (2009), p. 1-6. -
További szerzők:Rigó János (1958-) (szülész-nőgyógyász) Nagy Bálint (1956-) (molekuláris genetikus) Balogh Krisztián Makó Veronika Cervenak László Mézes Miklós Prohászka Zoltán Molvarec Attila (szülész-nőgyógyász)
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3.

001-es BibID:BIBFORM065298
Első szerző:Madách Krisztina
Cím:Elevated serum 70 kDa heat shock protein level reflects tissue damage and disease severity in the syndrome of hemolysis, elevated liver enzymes, and low platelet count / Krisztina Madách, Attila Molvarec, János Rigó Jr., Bálint Nagy, István Pénzes, István Karádi, Zoltán Prohászka
Dátum:2008
ISSN:0301-2115
Megjegyzések:We have recently demonstrated that serum 70 kDa heat shock protein (Hsp70) levels are increased in the syndrome of hemolysis, elevated liver enzymes, and low platelet count (HELLP syndrome). The aim of the present study was to investigate in an independent, larger cohort of patients whether serum Hsp70 levels are related to laboratory markers of HELLP syndrome.STUDY DESIGN:The study population included 14 patients with HELLP syndrome. Serum Hsp70 levels were measured by enzyme-linked immunosorbent assay. The relationship between serum Hsp70 levels and laboratory markers of hemolysis, hepatocellular damage, renal insufficiency, inflammation or disseminated intravascular coagulation (DIC), as well as platelet count was investigated by calculating correlation coefficients, standardized regression coefficients and by principal component analysis.RESULTS:Serum Hsp70 levels showed a very strong correlation to the markers of hemolysis (plasma free hemoglobin level, serum lactate dehydrogenase activity, and total bilirubin level) and of hepatocellular injury (serum aminotransferase activities), supported also by principal component analysis. Furthermore, circulating Hsp70 concentration reflected the severity of HELLP syndrome as expressed by the significant inverse correlation to the lowest platelet count. By contrast, there was no relationship between serum Hsp70 levels and markers of inflammation, coagulation, fibrinolysis or renal insufficiency.CONCLUSION:Elevated serum 70 kDa heat shock protein level seems to reflect tissue damage (hemolysis and hepatocellular injury) and disease severity in patients with HELLP syndrome. However, further investigations are needed to determine the clinical relevance of these findings.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
heat shock
elevated
HELLP syndrome
Megjelenés:European Journal Of Obstetrics Gynecology And Reproductive Biology 139 : 2 (2008), p. 133-138. -
További szerzők:Molvarec Attila (szülész-nőgyógyász) Rigó János (1958-) (szülész-nőgyógyász) Nagy Bálint (1956-) (molekuláris genetikus) Pénzes István Karádi István (1952-) (belgyógyász, kardiológus) Prohászka Zoltán
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4.

001-es BibID:BIBFORM065241
Első szerző:Molvarec Attila (szülész-nőgyógyász)
Cím:Circulating anti-heat-shock-protein antibodies in normal pregnancy and preeclampsia / Attila Molvarec, Zoltán Derzsy, Judit Kocsis, Tamás Bőze, Bálint Nagy, Krisztián Balogh, Veronika Makó, László Cervenak, Miklós Mézes, István Karádi, Zoltán Prohászka, János Rigó Jr.
Dátum:2009
ISSN:1355-8145
Megjegyzések:It has been previously reported that circulating anti-heat-shock-protein (Hsp) antibody levels are elevated in cardiovascular disorders. The aim of the present study was to determine circulating antihuman Hsp60, antimycobacterial Hsp65, and antihuman Hsp70 antibody levels in healthy pregnant women and preeclamptic patients and to investigate their relationship to the clinical characteristics of the study subjects, as well as to the markers of inflammation (C-reactive protein (CRP)), endothelial activation (von Willebrand factor antigen), or endothelial injury (fibronectin), oxidative stress (malondialdehyde) and to serum Hsp70 levels. Ninety-three preeclamptic patients and 127 normotensive healthy pregnant women were involved in this case control study. Serum anti-Hsp60, anti-Hsp65, anti-Hsp70, and Hsp70 levels were measured with enzyme-linked immunosorbent assay (ELISA). Serum CRP levels were determined by an autoanalyzer using the manufacturer's kit. Plasma von Willebrand factor antigen levels were quantified by ELISA, while plasma fibronectin concentration by nephelometry. Plasma malondialdehyde levels were measured by the thiobarbituric-acid-based colorimetric assay. For statistical analyses, nonparametric methods were applied. Anti-Hsp60, anti-Hsp65, and anti-Hsp70 antibodies were detected in all of our serum samples. There were no significant differences in serum anti-Hsp60, anti-Hsp65, and anti-Hsp70 antibody levels between the control and preeclamptic groups. Serum levels of Hsp70 and CRP, as well as plasma levels of VWF antigen, fibronectin, and malondialdehyde, were significantly higher in preeclamptic patients than in normotensive healthy pregnant women. Serum anti-Hsp60 antibody levels showed significant correlations with serum anti-Hsp65 antibody levels both in the control and the preeclamptic groups (Spearman R?=?0.55 and 0.59; p?<?0.001, respectively). However, no other relationship was found between clinical features (maternal age, smoking status, parity, body mass index, gestational age at blood draw, systolic and diastolic blood pressure, gestational age at delivery, and fetal birth weight) and measured laboratory parameters of the study subjects and serum anti-Hsp antibody levels in either study group. In conclusion, anti-Hsp60 and anti-Hsp70 antibodies as naturally occurring autoantibodies are present in the peripheral circulation of healthy pregnant women. Nevertheless, humoral immunity against heat shock proteins was not associated with preeclampsia. Further studies are warranted to explore the role of heat shock proteins and immune reactivity to them in the immunobiology of normal pregnancy and preeclampsia.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
circulating
anti heatschock
protein
preeclampsia
Megjelenés:Cell Stress & Chaperones. - 14 : 5 (2009), p. 491-498. -
További szerzők:Derzsy Zoltán Kocsis Judit (1967-) (onkológus) Bőze Tamás Nagy Bálint (1956-) (molekuláris genetikus) Balogh Krisztián Makó Veronika Cervenak László Mézes Miklós Karádi István (1952-) (belgyógyász, kardiológus) Prohászka Zoltán Rigó János (1958-) (szülész-nőgyógyász)
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5.

001-es BibID:BIBFORM065297
Első szerző:Molvarec Attila (szülész-nőgyógyász)
Cím:Association between tumor necrosis factor (TNF)-α G-308A gene polymorphism and preeclampsia complicated by severe fetal growth restriction / Attila Molvarec, Ágnes Jermendy, Bálint Nagy, Margit Kovács, Tibor Várkonyi, Petronella Hupuczi, Zoltán Prohászka, János Rigó Jr.
Dátum:2008
ISSN:0009-8981
Megjegyzések:Preeclampsia and HELLP (hemolysis, elevated liver enzymes, and low platelet count) syndrome are multifactorial disorders with genetic and environmental components. Given that the tumor necrosis factor (TNF)-alpha G-308A single nucleotide polymorphism (SNP) affects TNF-alpha gene transcription and that preeclampsia and HELLP syndrome are characterized by a shift towards a Th1-type maternal immune response with increased TNF-alpha production, the aim of the current study was to investigate whether this SNP is associated with preeclampsia and HELLP syndrome in a Caucasian population from Hungary. Additionally, we aimed to examine whether TNF-alpha G-308A polymorphism can influence the risk for fetal growth restriction in preeclamptic patients, which issue none of the earlier studies dealt with.METHODS:In a case-control study, we analyzed blood samples from 140 preeclamptic patients, 69 patients with HELLP syndrome and 144 normotensive, healthy pregnant women using the polymerase chain reaction (PCR)-restriction fragment length polymorphism (RFLP) method. We performed also a meta-analysis with our results and those of 8 previously published studies.RESULTS:There were no significant differences in the genotype and allele frequencies of the TNF-alpha G-308A polymorphism between preeclamptic patients and normotensive, healthy pregnant women. However, the mutant (TNF2 or A) allele occurred significantly more frequently in preeclamptic patients with IUGR than in those without IUGR (18.5% versus 7.1%, p=0.003). In addition, the frequency of the mutant allele carriers was significantly higher among preeclamptic patients with IUGR compared to those without IUGR (30.6% versus 12.8%, p=0.010). The mutant allele carriers were found to have an increased risk of severe IUGR-complicated preeclampsia, which was independent of maternal age, prepregnancy BMI and primiparity (odds ratio (OR): 2.89, 95% confidence interval (CI): 1.16-7.22, p=0.023; adjusted OR: 2.78, 95% CI: 1.04-7.45, p=0.042). Nevertheless, no significant differences were detected in the genotype and allele frequencies of the TNF-alpha G-308A polymorphism between patients with HELLP syndrome and control subjects. In the meta-analysis, no association was observed between this SNP and preeclampsia (summary OR: 0.956, 95% CI: 0.693-1.319).CONCLUSIONS:Although the meta-analysis demonstrated a lack of an overall association between TNF-alpha G-308A polymorphism and preeclampsia, our results suggest a role of this SNP in the risk of severe IUGR-complicated preeclampsia. However, further studies are required with a larger sample size to confirm our findings.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Preeclampsia
Gene
Polymorphism
TNF
Megjelenés:Clinica Chimica Acta. - 392 : 1-2 (2008), p. 52-57. -
További szerzők:Jermendy Ágnes Nagy Bálint (1956-) (molekuláris genetikus) Kovács Margit (belgyógyász, Budapest) Várkonyi Tibor Hupuczi Petronella (anaesthesiológus) Prohászka Zoltán Rigó János (1958-) (szülész-nőgyógyász)
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6.

001-es BibID:BIBFORM065315
Első szerző:Molvarec Attila (szülész-nőgyógyász)
Cím:Lipid, haemostatic and inflammatory variables in relation to the estrogen receptor [alfa] (ESR1) PvuII and XbaI gene polymorphisms / Molvarec Attila, Nagy Bálint, Kovács Margit, Walentin Szilvia, Imreh Éva, Rigó János Jr., Szalay János, Füst George, Prohászka Zoltán, Karádi István
Dátum:2007
ISSN:0009-8981
Megjegyzések:Estrogen is known to affect lipoprotein metabolism, the haemostatic system and inflammatory markers. Our aim was to determine whether estrogen receptor alpha (ESR1) PvuII and XbaI gene polymorphisms can influence lipid, haemostatic and inflammatory variables in healthy Caucasian women and men of reproductive age.METHODS:58 healthy women (aged between 18 and 45 years) and 55 healthy men (aged between 21 and 45 years) of reproductive age were enrolled in our study. FSH levels, lipid (total cholesterol, triglyceride, HDL cholesterol, lipoprotein(a), apo A-I, apo B), haemostatic (prothrombin time, activated partial thromboplastin time (aPTT), thrombin time, fibrinogen, factor V, VII, VIII, protein C, protein S, antithrombin III) and inflammatory (CRP) variables were measured on autoanalyzers using commercially available kits. Serum VLDL and LDL cholesterol concentrations were calculated with the equation of Friedewald. The ESR1 PvuII and XbaI genotypes were determined with PCR-RFLP method.RESULTS:In the total group, the ESR1 XbaI GG genotype carriers had significantly higher serum lipoprotein(a) concentrations than the AA or AG genotype carriers. Serum total cholesterol concentrations were significantly higher in healthy women with the PvuII CC genotype than in those with the TT or TC genotypes, whereas healthy women with the GG genotype of the ESR1 XbaI polymorphism had significantly higher serum total cholesterol and LDL cholesterol levels compared to those with the AA or AG genotypes. No other effects of the ESR1 PvuII and XbaI polymorphisms were found on the investigated lipid, haemostatic and inflammatory variables either in the total group or in women and men separately.CONCLUSIONS:The ESR1 PvuII and XbaI gene polymorphisms seem to affect lipoprotein metabolism in healthy subjects of peak reproductive age. However, further studies are needed to determine the molecular mechanisms by which the two polymorphisms could influence serum lipid levels.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
lipid
estrogen receptor
inflammatory
gene
polymorphism
Megjelenés:Clinica Chimica Acta. - 380 : 1-2 (2007), p. 157-164. -
További szerzők:Nagy Bálint (1956-) (molekuláris genetikus) Kovács Margit (belgyógyász, Budapest) Walentin Szilvia Imreh Éva Rigó János (1958-) (szülész-nőgyógyász) Szalay János Füst György (Budapest) Prohászka Zoltán Karádi István (1952-) (belgyógyász, kardiológus)
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7.

001-es BibID:BIBFORM065317
Első szerző:Molvarec Attila (szülész-nőgyógyász)
Cím:Serum heat shock protein 70 levels are decreased in normal human pregnancy / Molvarec Attila, Rigó János, Nagy Bálint, Walentin Szilvia, Szalay János, Füst George, Karádi István, Prohászka Zoltán
Dátum:2007
ISSN:0165-0378
Megjegyzések:Heat shock proteins (Hsps) are primarily known to be intracellular proteins with molecular chaperone and cytoprotective functions. However, Hsp60 and Hsp70 have been found in the serum and plasma of healthy non-pregnant individuals. We aimed to compare serum Hsp70 concentrations in healthy pregnant women with those of healthy non-pregnant women and to determine factors influencing serum Hsp70 levels in normal pregnancy. One hundred and seventy six healthy pregnant women with uncomplicated pregnancies (age, 17-44 years; gestational age, 20-41 weeks) and 81 healthy, age-matched non-pregnant women (age, 22-40 years) were enrolled in this cross-sectional study. Serum Hsp70 concentrations were measured using an enzyme-linked immunosorbent assay, and were significantly lower in healthy pregnant women than in healthy non-pregnant women (median (25-75 percentile): 0.29 (0.20-0.35)ng/ml versus 1.27 (0.86-1.72)ng/ml; p<0.001). In healthy pregnant women, there was a statistically significant negative correlation between maternal age and serum Hsp70 concentration (Spearman R=-0.35; p<0.001) and a significant positive correlation between gestational age and serum Hsp70 level (Spearman R=0.35; p<0.001). The capacity of extracellular Hsp70 to elicit innate and adaptive proinflammatory immune responses might be harmful in pregnancy and lead to immune rejection of the fetal semi-allograft. We hypothesize that decreased circulating Hsp70 levels are due to unknown regulatory mechanisms aimed at maintaining immune tolerance in pregnancy. In conclusion, serum Hsp70 concentrations are decreased in normal human pregnancy; however, further studies are needed to explain the observed differences between pregnant and non-pregnant women.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
serum
heat
schock
protein-70
decreased
Megjelenés:Journal Of Reproductive Immunology. - 74 : 1-2 (2007), p. 163-169. -
További szerzők:Rigó János (1958-) (szülész-nőgyógyász) Nagy Bálint (1956-) (molekuláris genetikus) Walentin Szilvia Szalay János Füst György (Budapest) Karádi István (1952-) (belgyógyász, kardiológus) Prohászka Zoltán
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Intézményi repozitóriumban (DEA) tárolt változat
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8.

001-es BibID:BIBFORM065320
Első szerző:Molvarec Attila (szülész-nőgyógyász)
Cím:Association of increased serum heat shock protein 70 and C-reactive protein concentrations and decreased serum [alfa]2-HS glycoprotein concentration with the syndrome of hemolysis, elevated liver enzymes, and low platelet count / Molvarec Attila, Prohászka Zoltán, Nagy Bálint, Kalabay László, Szalay János, Füst Georg, Karádi István, Rigó János
Dátum:2007
ISSN:0165-0378
Megjegyzések:The primary aim of this study was to determine serum Hsp70 concentrations in HELLP syndrome. We measured also the serum concentrations of three acute phase proteins: C-reactive protein (CRP), alpha(2)-macroglobulin (AMG) and alpha(2)-HS glycoprotein (AHSG). Ten severe preeclamptic patients with HELLP syndrome, 20 severe preeclamptic patients without HELLP syndrome and 20 normotensive, healthy pregnant women were included in this case-control study. Serum concentrations of Hsp70, CRP, AMG and AHSG were measured using an enzyme-linked immunosorbent assay (Hsp70), particle-enhanced immunoturbidimetric assay (CRP) and radial immunodiffusion (AMG, AHSG). The serum Hsp70 and CRP concentrations were significantly higher, whereas the serum AHSG concentration was significantly lower in the HELLP group (H) than the severe preeclamptic (P) and control (C) groups (median (25-75 percentile); Hsp70: 2.02 ng/ml (0.76-2.23) (H) versus 0.54 ng/ml (0.47-0.79) (P), p<0.01, and 0.30 ng/ml (0.27-0.33) (C), p<0.001; CRP: 43.9 mg/l (27.1-84.5) (H) versus 6.5 mg/l (2.7-10.7) (P), p<0.001, and 2.5 mg/l (1.1-6.7) (C), p<0.001; AHSG: 588 microg/ml (492-660) (H) versus 654 microg/ml (576-768) (P), p<0.05, and 738 microg/ml (666-804) (C), p<0.01, respectively). The serum AMG concentration did not differ between the study groups. In the HELLP group, there was a statistically significant negative correlation between serum Hsp70 concentration and platelet count (Spearman R=-0.69, p=0.026). In conclusion, serum Hsp70 and CRP concentrations are increased, whereas serum AHSG concentration is decreased, in HELLP syndrome. The maternal systemic inflammation seems to be more pronounced in HELLP syndrome than preeclampsia without HELLP syndrome, as suggested by the alterations in serum CRP and AHSG levels. However, it requires further investigation to determine whether these changes are causes or consequences of the disease.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
serum
heat
schock
protein-70
C-reactive
Megjelenés:Journal Of Reproductive Immunology. - 73 : 2 (2007), p. 172-179. -
További szerzők:Prohászka Zoltán Nagy Bálint (1956-) (molekuláris genetikus) Kalabay László Szalay János Füst György (Budapest) Karádi István (1952-) (belgyógyász, kardiológus) Rigó János (1928-) (sebész, ortopéd traumatológus)
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Intézményi repozitóriumban (DEA) tárolt változat
Borító:

9.

001-es BibID:BIBFORM065322
Első szerző:Molvarec Attila (szülész-nőgyógyász)
Cím:Association of elevated serum heat-shock protein 70 concentration with transient hypertension of pregnancy, preeclampsia and superimposed preeclampsia : a case-control study / A. Molvarec, Z. Prohászka, B. Nagy, J. Szalay, G. Füst, I. Karádi, J. Rigó Jr.
Dátum:2006
ISSN:0950-9240
Megjegyzések:Our aim was to investigate the association between serum heat-shock protein (Hsp) 70 concentration and hypertensive disorders of pregnancy. One hundred and forty-two pregnant women with hypertensive disorders (93 with preeclampsia, 29 with transient hypertension of pregnancy and 20 with superimposed preeclampsia) and 127 normotensive, healthy pregnant women were included in the study. Serum Hsp70 concentration was measured using enzyme-linked immunosorbent assay. The serum Hsp70 concentration was significantly higher in patients with transient hypertension of pregnancy, in preeclamptic patients and in patients with superimposed preeclampsia than in the control group (median (25-75 percentile): 0.66 (0.52-0.84), 0.55 (0.42-0.80), 0.61 (0.42-0.91) ng/ml vs 0.31 (0.27-0.39) ng/ml, respectively; P<0.001). Multivariate logistic regression analysis showed independent association of elevated serum Hsp70 level with transient hypertension of pregnancy, preeclampsia and superimposed preeclampsia. The difference in serum Hsp70 concentration between preeclamptic patients and the control group was statistically significant in each gestational age category. In the groups of preeclamptic and superimposed preeclamptic patients, there was no significant difference in serum Hsp70 concentration between mild and severe preeclamptic patients, between patients with late and early onset of the disease, as well as between preeclamptic patients without and with foetal growth restriction. In conclusion, serum Hsp70 concentration is elevated in transient hypertension of pregnancy, in preeclampsia and in superimposed preeclampsia. Circulating Hsp70 may not only be a marker for these conditions, but might also play a role in their pathogenesis. However, further studies are needed to explore its role in the pathogenesis of hypertensive disorders of pregnancy.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
serum
heat schock
protein-70
pregnancy
Megjelenés:Journal Of Human Hypertension. - 20 : 10 (2006), p. 780-786. -
További szerzők:Prohászka Zoltán Nagy Bálint (1956-) (molekuláris genetikus) Szalay Judit Füst György (Budapest) Karádi István (1952-) (belgyógyász, kardiológus) Rigó János (1958-) (szülész-nőgyógyász)
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Intézményi repozitóriumban (DEA) tárolt változat
Borító:

10.

001-es BibID:BIBFORM065355
Első szerző:Szalai Csaba
Cím:Involvement of polymorphisms in the chemokine system in the susceptibility for coronary artery disease (CAD). Coincidence of elevated Lp(a) and MCP-1 : 2518 G/G genotype in CAD patients / Csaba Szalai, Jenő Duba, Zoltán Prohászka, Ákos Kalina, Teréz Szabó, Bálint Nagy, Laura Horváth, Albert Császár
Dátum:2001
ISSN:0021-9150
Megjegyzések:The central role of chemokines in the pathogenesis of atherosclerosis has been made clear. Recently polymorphisms in the gene regulatory region of MCP-1 and in the promoter region of RANTES have been found, which increase the expression of these chemokines. We investigated the role of these polymorphisms together with the chemokine SDF-1?801A and the chemokine receptors CCR2-64I and CCR5?32 mutations in 318 patients with coronary artery disease (CAD) referred to coronary bypass surgery, comparing them with 320 healthy controls. The prevalence of the MCP-1 ?2518 G/G homozygotes was significantly higher among CAD patients than among controls (P<0.005; OR=2.2 (95% CI 1.25?3.92). The Lp(a) levels of CAD patients with G/G genotype were significantly higher than those in patients with G/A or A/A genotypes. No CAD patients homozygous for the CCR5?32 and CCR2-64I mutations have been found. The genotype distributions of the two alleles deviated from the Hardy Weinberg equilibrium in patients, indicating that the numbers of homozygotes were significantly lower than expected. The MCP-1 ?2518G variant in homozygous form appears as a genetic risk factor for severe CAD. This genotype is associated with elevated Lp(a) levels in patients. Individuals homozygous for CCR2-64I or CCR5?32 mutations are at reduced risk for severe CAD.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
polymorphism
coronary
artery
Lp(a)
Genotype
Megjelenés:Atherosclerosis. - 158 : 1 (2001), p. 233-239. -
További szerzők:Duba Jenő Prohászka Zoltán Kalina Ákos Szabó Terézia Nagy Bálint (1956-) (molekuláris genetikus) Horváth Laura Császár Albert
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11.

001-es BibID:BIBFORM065211
Első szerző:Szelényi Zsuzsanna
Cím:Inflammation and oxidative stress caused by nitric oxide synthase uncoupling might lead to left ventricular diastolic and systolic dysfunction in patients with hypertension / Zsuzsanna Szelényi, Ádám Fazakas, Gábor Szénási, Melinda Kiss, Narcis Tegze, Bertalan Csaba Fekete, Eszter Nagy, Imre Bodó, Bálint Nagy, Attila Molvarec, Attila Patócs, Lilla Pepó, Zoltán Prohászka, András Vereckei
Dátum:2015
ISSN:1671-5411
Megjegyzések:OBJECTIVE:To investigate the role of oxidative stress, inflammation, hypercoagulability and neuroendocrine activation in the transition of hypertensive heart disease to heart failure with preserved ejection fraction (HFPEF).METHODS:We performed echocardiography for 112 patients (? 60 years old) with normal EF (18 controls and 94 with hypertension), and determined protein carbonylation (PC), and tetrahydrobiopterin (BH4), C-reactive protein (CRP), interleukin-6 (IL-6), tumor necrosis factor-? (TNF-?), fibrinogen, plasminogen activator inhibitor type-I (PAI-I), von Willebrand factor, chromogranin A (cGA) and B-type natriuretic peptide (BNP) levels from their blood samples.RESULTS:We found that 40% (38/94) of the patients with hypertension (HT) had no diastolic dysfunction (HTDD-), and 60% (56/94) had diastolic dysfunction (HTDD+). Compared to the controls, both patient groups had increased PC and BH4, TNF-?, PAI-I and BNP levels, while the HTDD+ group had elevated cGA and CRP levels. Decreased atrial and longitudinal left ventricular (LV) systolic and diastolic myocardial deformation (strain and strain rate) was demonstrated in both patient groups versus the control. Patients whose LV diastolic function deteriorated during the follow-up had elevated PC and IL-6 level compared to their own baseline values, and to the respective values of patients whose LV diastolic function remained unchanged. Oxidative stress, inflammation, BNP and PAI-I levels inversely correlated with LV systolic, diastolic and atrial function.CONCLUSIONS:In patients with HT and normal EF, the most common HFPEF precursor condition, oxidative stress and inflammation may be responsible for LV systolic, diastolic and atrial dysfunction, which are important determinants of the transition of HT to HFPEF.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
heart failure
hypertension
Inflammation
oxidative stress
Megjelenés:Journal of Geriatric Cardiology 12 (2015), p. 1-10. -
További szerzők:Fazakas Ádám Szénási Gábor Kiss Melinda Tegze, Narcis Fekete Bertalan C. Nagy Eszter (Budapest) Bodó Imre Nagy Bálint (1956-) (molekuláris genetikus) Molvarec Attila (szülész-nőgyógyász) Patócs Attila Pepó Lilla Prohászka Zoltán Vereckei András
Internet cím:DOI
Intézményi repozitóriumban (DEA) tárolt változat
Borító:

12.

001-es BibID:BIBFORM065319
Első szerző:Vallus Gábor (érsebész)
Cím:Factor V Leiden and apolipoprotein E genotypes in severe femoropopliteal atherosclerosis with restenosis / Gábor Vallus, Béla Dlustus, György Acsády, Zoltán Papp, Judit Skopál, Zoltán Nagy, Zoltán Prohászka, László Romics, István Karádi, Bálint Nagy
Dátum:2007
ISSN:0009-8981
Megjegyzések:BACKGROUND:The role of factor V (Leiden) mutation, thrombophilia, and apolipoprotein E (apoE) alleles in the pathogenesis of accelerated atherosclerosis and restenosis was studied in patients requiring reoperation within five years after femoropopliteal angioplasty with artificial grafts.METHODS:One hundred ninety-eight consecutive patients with femoropopliteal atherosclerotic disease, reoperated for restenosis were contacted by phone and 100 of them returned for laboratory and clinical work-up. In addition to clinical evaluation and routine laboratory investigations, parameters of lipoprotein metabolism, factor V (Leiden) mutation and apolipoprotein E (apoE) allele were studied by PCR amplification of DNA and endonuclease digestion techniques.RESULTS:A significantly higher incidence of factor V (Leiden) mutation was found in patients with atherosclerosis and restenosis, compared to 445 healthy blood donors (13/200, 6.5% vs. 34/890, 3.8%, p=0.0379). Distribution of the alleles of the apolipoprotein E (apoE) gene was different, when the patients were compared to 372 controls; however, the difference only approached the level of statistical significance (25/200, 12.5% vs. 56/744, 7.5%, p=0.0515). Comparing the two groups, the number of epsilon4 allele carriers was significantly higher among patients with restenosis (25/100, 25% vs. 53/272, 14%, p=0.0147).CONCLUSION:Factor V (Leiden) mutation may influence the progression of atherosclerosis and the development of restenosis after revascularization in patients with accelerated femoropopliteal atherosclerosis. Further investigation is needed whether long-term anticoagulation has an impact or not on the course of disease in such cases. ApoE epsilon4 allele should be screened in patients with femoropopliteal atherosclerosis, because it indicates a faster progression of atherosclerosis and may predict restenosis after revascularization procedure.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Factor V
Leiden mutation
apolipoprotein E
genotypes
femoropopliteal
atherosclerosis
Megjelenés:Clinica Chimica Acta. - 377 : 1-2 (2007), p. 256-260. -
További szerzők:Dlustus Béla (1945-) (érsebész) Acsády György Papp Zoltán (1942-) (szülész-nőgyógyász, genetikus) Skopál Judit Nagy Zoltán Prohászka Zoltán Romics László Karádi István (1952-) (belgyógyász, kardiológus) Nagy Bálint (1956-) (molekuláris genetikus)
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Intézményi repozitóriumban (DEA) tárolt változat
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