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001-es BibID:BIBFORM074846
Első szerző:Heikinheimo, Kristiina
Cím:Genetic changes in sporadic keratocystic odontogenic tumors (odontogenic keratocysts) / K. Heikinheimo, K. J. Jee, P. R. Morgan, B. Nagy, S. Knuutila, I. Leivo
Dátum:2007
ISSN:0022-0345
Megjegyzések:Little is known about the genetic background of keratocystic odontogenic tumors (KCOT, odontogenic keratocysts). Our aim was to characterize genomic aberrations in sporadic KCOT using cDNA-expression arrays and array-comparative genomic hybridization. For cDNA-expression arrays, 10 KCOT specimens and 20 fetal tooth germs were studied. Quantitative real-time reverse-transcription/polymerase chain-reaction and immunohistochemical studies were also undertaken. Several genes were over-expressed in 12q13, including cytokeratin 6B (KRT6B) ( approximately 10-fold), epidermal growth factor receptor ERBB3 (approximately 4.7-fold), and glioma-associated oncogene homologue 1 (GLI1) (approximately 5- to 12-fold). One amplicon (approximately 0.7 Mega base pairs [Mbp]), covering several genes involved in the regulation of cell growth, was found in 12q13.2. Deletions were found in 3q13.1, 5p14.3, and 7q31.3, including the cell-adhesion-related gene cadherin 18 (CDH18) and leukocyte cell adhesion molecule (ALCAM, MEMD). Over-expressed and amplified genes in 12q13, also reported in several other tumors and cell lines, may contribute to the persistent growth characteristics of KCOT.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
odontogenic
tumor
genetic
changes
Megjelenés:Journal of Dental Research. - 86 : 6 (2007), p. 544-549. -
További szerzők:Jee, Kowan Ja Morgan, Peter R. Nagy Bálint (1956-) (molekuláris genetikus) Knuutila, Sakari Leivo, Ilmo
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001-es BibID:BIBFORM065301
Első szerző:Rautava, J.
Cím:ERBB receptors in developing, dysplastic and malignant oral epithelia / J. Rautava, K. J. Jee, P. J. Miettinen, B. Nagy, S. Myllykangas, E. W. Odell, T. Soukka, P. R. Morgan, K. Heikinheimo
Dátum:2008
ISSN:1368-8375
Megjegyzések:Some oral squamous cell carcinomas (OSCCs) overexpress epidermal growth factor receptor (EGFR) but little is known about the receptor system overall during oral carcinogenesis. We studied all four ERBB receptors (EGFR, ERBB2-4) in developing (n = 2), normal (n = 7), dysplastic (n = 23) and malignant (n = 26) oral epithelia by means of immunohistochemistry. The investigations were supplemented by conducting reverse transcription-polymerase chain reactions in relation to 13 OSCC samples. All four ERBB receptors were detected in developing oral epithelium and, to a lesser degree, in mature oral epithelium. An increase in EGFR immunoreactivity was seen in 61% and 54% of dysplasias and OSCCs, respectively. The corresponding percentages for ERBB2 were 48 and 12, for ERBB3 48 and 43. ERBB4 nuclear staining was increased in 30% of dysplasias and 26% of OSCCs. Changes in ERBB receptor mRNA levels were not statistically significant. The results show that ERBB receptor profiles are specific to each tumour. Increased nuclear translocation of ERBB4 in some OSCCs may alter transcription of target genes and be associated with cancer progression. This information may be useful for clinicians as EGFR inhibitors are becoming treatment options in modern oncology.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
ERBB
Receptor
oral
Epithelial
cancer
Megjelenés:Oral Oncology. - 44 : 3 (2008), p. 227-235. -
További szerzők:Jee, Kowan Ja Miettinen, Päivi J. Nagy Bálint (1956-) (molekuláris genetikus) Myllykangas, Samuel Odell, Edward William Soukka, Tero Morgan, Peter R. Heikinheimo, Kristiina
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