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001-es BibID:	BIBFORM071421
Első szerző:	Biró Orsolya (molekuláris biológus)
Cím:	Various levels of circulating exosomal total-miRNA and miR-210 hypoxamiR in different forms of pregnancy hypertension / Orsolya Biró, Bálint Alasztics, Attila Molvarec, József Joó, Bálint Nagy, János Rigó Jr.
Dátum:	2017
ISSN:	2210-7789
Megjegyzések:	IntroductionHypertension is a common complication during pregnancy, affecting 10% of pregnant women worldwide. Several microRNA (miRNA) were shown to be involved in hypertensive disorders of pregnancy. In preeclampsia (PE), placental dysfunction causes the enhanced release of extracellular vesicle-derived miRNAs. The hypoxia-sensitive hsa-mir-210 is the most common PE-associated miRNA, but its exosomal profile has not been investigated.ObjectivesOur aims were to measure exosomal total-miRNA concentration and to perform expression analysis of circulating exosomal hsa-miR-210 in women affected by chronic hypertension (CHT) gestational hypertension (GHT) or PE.Materials and methodsWe collected plasma samples from women with CHT, GHT, PE (moderate: mPE and severe: sPE) and from normotensive pregnancies. Exosomal miRNAs were extracted and miRNA concentration was measured. RT-PCR was carried out with hsa-miR-210-3p-specific primers and relative expression was calculated using the comparative Ct method.ResultsThe total-miRNA concentration was different in the disease subgroups, and was significantly higher in mPE and sPE compared to the other groups. We found a significant difference in the relative exosomal hsa-miR-210-3p expression between all hypertensive groups compared to the normotensive samples, but significant upregulation was only observed in case of mPE and sPE patients. Both the level of total-miRNA and hsa-miR-210 expression was higher in case of severe PE.ConclusionsThe level of circulating exosomal total-miRNA and hsa-miR-210 was elevated in women with PE, and it was higher in the severe form. We showed that hsa-miR-210 is secreted via exosomes, which may have a role in the pathomechanism of the disease.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban miRNA miR-210 circulating
Megjelenés:	Pregnancy Hypertension 10 (2017), p. 207-212. -
További szerzők:	Alasztics Bálint Molvarec Attila (szülész-nőgyógyász) Joó József Gábor (1965-) (szülész-nőgyógyász) Nagy Bálint (1956-) (molekuláris genetikus) Rigó János (1958-) (szülész-nőgyógyász)
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001-es BibID:	BIBFORM065214
Első szerző:	Rigó János (szülész-nőgyógyász)
Cím:	Trends in maternal mortality in Hungary between 1978 and 2010 / János Rigó Jr., György Csákány, Marcella Laky, Bálint Nagy, Endre Horváth, József Gábor Joó
Dátum:	2014
ISSN:	0301-2115
Megjegyzések:	OBJECTIVE:We evaluated the trends of the last decades in maternal mortality in Hungary and compared Hungarian results with those of other European countries.STUDY DESIGN:Cases of maternal death in Hungary during the study period from calendar year 1978 to 2010 were analyzed in a retrospective manner to characterize mortality distribution and to identify potential clinical or demographic predictors. Data in all cases were extracted both from the national Obstetric Registry operated by the National Institute of Gynecology and Obstetrics, from the Hungarian Central Bureau of Statistics and from the National Public Health and Medical Officer Service. Detailed clinical data were obtained based on obligatory reporting by individual clinical institutions.RESULTS:The annual maternal mortality rate (MMR) was 26.7 per 100,000 live births in the period 1978-1987 and declined significantly to 10.9 per 100,000 live births in the period 1997-2010. In the period 1988-1996 (with missing associated clinical and demographic data) the MMR was 16.4 per 100,000 live births. The proportion of delivery-associated causes of death increased significantly between the two study periods from 49.4% to 62.9% (p<0.05). Among obstetric causes of death, the rate of thromboembolism showed a significant increase, while there was a trend toward a decline in rate of maternal deaths attributable to hemorrhagic shock. Among medical causes of death not directly attributable to obstetric complications, the rate of renal and gastrointestinal etiologies declined significantly throughout the study periods.CONCLUSIONS:We observed a marked decline in maternal mortality during the last few decades in Hungary. Recent changes in mortality distribution highlight current characteristics of pregnancy care in Hungary and may help identify strategies for future improvement.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban Maternal mortality Hungary Obstetric
Megjelenés:	European Journal Of Obstetrics Gynecology And Reproductive Biology 173 (2014), p. 29-33. -
További szerzők:	Csákány György Laky Marcella Nagy Bálint (1956-) (molekuláris genetikus) Horváth Endre Joó József Gábor (1965-) (szülész-nőgyógyász)
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001-es BibID:	BIBFORM074860
Első szerző:	Varga István (belgyógyász)
Cím:	Analysis of maternal circulation and renal function in physiologic pregnancies; parallel examinations of the changes in the cardiac output and the glomerular filtration rate / Varga I., Rigó J. Jr., Somos P., Joó J. G., Nagy B.
Dátum:	2000
ISSN:	1057-0802
Megjegyzések:	OBJECTIVE:The aim of the study was to examine the temporal relations between the parameters of the maternal hemodynamics and homeostasis in different phases of pregnancy and the postpartum period.METHODS:Eleven healthy pregnant women were involved in the study. The value of the peripheric vasodilatation was measured by the ratio I/A of the maternal sphygmogram (I: incisure point, A: amplitude of the carotid pressure curve). The change of the cardiac output was determined by the ejection angle composed from maternal carotid sphygmogram and its first electrical derivate (dP/dT). The glomerular filtration rate (GFR) was measured with the in vitro radiofluorescent method.RESULTS:The primary peripheral vasodilatation and GFR increase occur early in the first trimester of a normal pregnancy, start to decrease at the end of the third trimester, and return to the normal value in the postpartum period. The increase of GFR precedes the increase of cardiac output. The cardiac output increases progressively from the first trimester and starts to decrease in the third trimester of a normal pregnancy. The extracellular volume increases at the beginning of first trimester progressively until the end of pregnancy and returns to the normal value in the postpartum period.DISCUSSION:The increase of GFR and the cardiac output during pregnancy are contributed to volume-establishment and to the cessation of the special "underfilled" condition of the maternal circulation in the normal pregnancy. We suppose that the maximal increase of GFR precedes the maximal increase of the cardiac output because the GFR increase is caused by maximal renal vasodilatation. The increase of cardiac output is caused in the first trimester by the shunt effect of the enhanced renal blood flow of maternal kidneys, and in the second and third trimester by the shunt effect of the feto-placental unit and the shunt effect of the maternal kidneys.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban maternal circulation pregnancy renal function
Megjelenés:	Journal of Maternal-Fetal Medicine. - 9 : 2 (2000), p. 97-104. -
További szerzők:	Rigó János (1958-) (szülész-nőgyógyász) Somos Péter Joó József Gábor (1965-) (szülész-nőgyógyász) Nagy Bálint (1956-) (molekuláris genetikus) Nagy Bálint (1956-) (molekuláris genetikus)
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001-es BibID:	BIBFORM067068
Első szerző:	Varga István (belgyógyász)
Cím:	Anyai keringés és vesefunctio vizsgálatok egészséges terhesekben : a GFR és az ejectios szög változásainak párhuzamos vizsgálata / Varga István, Rigó János, Somos Péter, Nagy Bálint, Joó József
Dátum:	1999
Megjegyzések:	This study present follow-up examinations of maternal circulation and renal function in various trimesters of pregnancy and the postpartum period. The authors came across certain parameters which have predictive-value in connection with circulatory changes and adaptation in pregnancy. According to their results in good accordance with those of other research groups in the mechanism of circulatory adaptation, an increase in the glomerular filtration rate precedes and increase in the cardiac output.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok magyar nyelvű folyóiratközlemény hazai lapban anyai keringés ejectios szög GFR
Megjelenés:	Magyar Nőorvosok Lapja. - 62 : 1 (1999), p. 19-23. -
További szerzők:	Rigó János (1958-) (szülész-nőgyógyász) Somos Péter Nagy Bálint (1956-) (molekuláris genetikus) Joó József Gábor (1965-) (szülész-nőgyógyász)
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