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001-es BibID:	BIBFORM065319
Első szerző:	Vallus Gábor (érsebész)
Cím:	Factor V Leiden and apolipoprotein E genotypes in severe femoropopliteal atherosclerosis with restenosis / Gábor Vallus, Béla Dlustus, György Acsády, Zoltán Papp, Judit Skopál, Zoltán Nagy, Zoltán Prohászka, László Romics, István Karádi, Bálint Nagy
Dátum:	2007
ISSN:	0009-8981
Megjegyzések:	BACKGROUND:The role of factor V (Leiden) mutation, thrombophilia, and apolipoprotein E (apoE) alleles in the pathogenesis of accelerated atherosclerosis and restenosis was studied in patients requiring reoperation within five years after femoropopliteal angioplasty with artificial grafts.METHODS:One hundred ninety-eight consecutive patients with femoropopliteal atherosclerotic disease, reoperated for restenosis were contacted by phone and 100 of them returned for laboratory and clinical work-up. In addition to clinical evaluation and routine laboratory investigations, parameters of lipoprotein metabolism, factor V (Leiden) mutation and apolipoprotein E (apoE) allele were studied by PCR amplification of DNA and endonuclease digestion techniques.RESULTS:A significantly higher incidence of factor V (Leiden) mutation was found in patients with atherosclerosis and restenosis, compared to 445 healthy blood donors (13/200, 6.5% vs. 34/890, 3.8%, p=0.0379). Distribution of the alleles of the apolipoprotein E (apoE) gene was different, when the patients were compared to 372 controls; however, the difference only approached the level of statistical significance (25/200, 12.5% vs. 56/744, 7.5%, p=0.0515). Comparing the two groups, the number of epsilon4 allele carriers was significantly higher among patients with restenosis (25/100, 25% vs. 53/272, 14%, p=0.0147).CONCLUSION:Factor V (Leiden) mutation may influence the progression of atherosclerosis and the development of restenosis after revascularization in patients with accelerated femoropopliteal atherosclerosis. Further investigation is needed whether long-term anticoagulation has an impact or not on the course of disease in such cases. ApoE epsilon4 allele should be screened in patients with femoropopliteal atherosclerosis, because it indicates a faster progression of atherosclerosis and may predict restenosis after revascularization procedure.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban Factor V Leiden mutation apolipoprotein E genotypes femoropopliteal atherosclerosis
Megjelenés:	Clinica Chimica Acta. - 377 : 1-2 (2007), p. 256-260. -
További szerzők:	Dlustus Béla (1945-) (érsebész) Acsády György Papp Zoltán (1942-) (szülész-nőgyógyász, genetikus) Skopál Judit Nagy Zoltán Prohászka Zoltán Romics László Karádi István (1952-) (belgyógyász, kardiológus) Nagy Bálint (1956-) (molekuláris genetikus)
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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