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001-es BibID:BIBFORM065356
Első szerző:Kalina Ákos
Cím:The association of serum lipoprotein(a) levels, apolipoprotein(a) size and (TTTTA)n polymorphism with coronary heart disease / Akos Kalina, Albert Csaszar, George Fust, Balint Nagy, Csaba Szalai, Istvan Karadi, Jeno Duba, Zoltan Prohaszka, Laura Horvath, Hans Dieplinger
Dátum:2001
ISSN:0009-8981
Megjegyzések:Background: The association between lipoprotein(a) levels, apolipoprotein(a) size and the (TTTTA)n polymorphism which is located in the 5· non-coding region of the apo(a) gene was studied in 263 patients with severe coronary heart disease and 97 healthy subjects. Methods: Lp(a) levels were measured by ELISA, apo(a) isoform size was determined by SDS?agarose gel electrophoresis, and analysis of the (TTTTA)n was carried out by PCR. For statistical calculation, both groups were divided into low (at least one apo(a) isoform with ?22 Kringle IV) and high (both isoforms with >22 KIV) apo(a) isoform sizes, and into low number (<10 in both alleles) and high number of (?10 at least one allele) TTTTA repeats. Results: Lp(a) levels were higher (P=0.007), apo(a) isoforms size ?22 KIV and TTTTA repeats ?10 were more frequent (P=0.007 and 0.01) in cases than in controls. Lp(a) levels were found to be increased with low apo(a) weight in both groups (both P<0.0001). In multivariate logistic regression analysis, only the Lp(a) levels (P=0.005) and (TTTTA)n polymorphism (P=0.002) were found to be significantly associated with CHD. Conclusion: Nevertheless, these results indicate that in CHD patients the (TTTTA)n polymorphism has an effect on Lp(a) levels which is independent of the apo(a) size.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
apolipoprotein(a)
(TTTTA)n
Polymorphism
serum
association
coronary
heart
diseases
Megjelenés:Clinica Chimica Acta. - 309 : 1 (2001), p. 45-51. -
További szerzők:Császár Albert Füst György (Budapest) Nagy Bálint (1956-) (molekuláris genetikus) Szalai Csaba Karádi István (1952-) (belgyógyász, kardiológus) Duba Jenő Prohászka Zoltán Horváth Laura Dieplinger, Hans
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Intézményi repozitóriumban (DEA) tárolt változat
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2.

001-es BibID:BIBFORM065355
Első szerző:Szalai Csaba
Cím:Involvement of polymorphisms in the chemokine system in the susceptibility for coronary artery disease (CAD). Coincidence of elevated Lp(a) and MCP-1 : 2518 G/G genotype in CAD patients / Csaba Szalai, Jenő Duba, Zoltán Prohászka, Ákos Kalina, Teréz Szabó, Bálint Nagy, Laura Horváth, Albert Császár
Dátum:2001
ISSN:0021-9150
Megjegyzések:The central role of chemokines in the pathogenesis of atherosclerosis has been made clear. Recently polymorphisms in the gene regulatory region of MCP-1 and in the promoter region of RANTES have been found, which increase the expression of these chemokines. We investigated the role of these polymorphisms together with the chemokine SDF-1?801A and the chemokine receptors CCR2-64I and CCR5?32 mutations in 318 patients with coronary artery disease (CAD) referred to coronary bypass surgery, comparing them with 320 healthy controls. The prevalence of the MCP-1 ?2518 G/G homozygotes was significantly higher among CAD patients than among controls (P<0.005; OR=2.2 (95% CI 1.25?3.92). The Lp(a) levels of CAD patients with G/G genotype were significantly higher than those in patients with G/A or A/A genotypes. No CAD patients homozygous for the CCR5?32 and CCR2-64I mutations have been found. The genotype distributions of the two alleles deviated from the Hardy Weinberg equilibrium in patients, indicating that the numbers of homozygotes were significantly lower than expected. The MCP-1 ?2518G variant in homozygous form appears as a genetic risk factor for severe CAD. This genotype is associated with elevated Lp(a) levels in patients. Individuals homozygous for CCR2-64I or CCR5?32 mutations are at reduced risk for severe CAD.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
polymorphism
coronary
artery
Lp(a)
Genotype
Megjelenés:Atherosclerosis. - 158 : 1 (2001), p. 233-239. -
További szerzők:Duba Jenő Prohászka Zoltán Kalina Ákos Szabó Terézia Nagy Bálint (1956-) (molekuláris genetikus) Horváth Laura Császár Albert
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DOI
Intézményi repozitóriumban (DEA) tárolt változat
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