CCL

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1.

001-es BibID:BIBFORM074858
Első szerző:Aalto, Yan
Cím:Distinct gene expression profiling in chronic lymphocytic leukemia with 11q23 deletion / Y. Aalto, W. El-Rifai, L. Vilpo, J. Ollila, B. Nagy, M. Vihinen, J. Vilpo, S. Knuutila
Dátum:2001
ISSN:0887-6924
Megjegyzések:Chronic lymphocytic leukemia (CLL) is a heterogeneous disease with regard to its clinical course. The limitations of the methods currently available for prognostic assessment in CLL do not allow accurate prediction of the risk of disease progression in individual patients. The recently developed cDNA array technique provides a unique opportunity to study gene expression in various malignancies. To identify new molecular markers for prognostication of CLL patients, we analyzed cDNA arrays by using hierarchical clustering and standard statistic t-test on 34 CLL patients. We found significant expression differences in 78 genes compared to the reference tonsillar B lymphocytes. A cluster of genes, LCP1, PARP, BLR1, DEK, NPM, MCL1, SLP76, STAM, HIVEP1, EVI2B, CD25, HTLF, HIVEP2, BCL2, MNDA, PBX3, EB12, TCF1, CGRP, CD14, ILB, GZMK, GPR17 and CD79B, was associated (P < 0.05) with the unfavorable 11q deletion and also with the unfavorable Binet stages B and C. We present here gene expression profiling that is associated with CLL patients with the 11q23 deletion. Many of the genes in the cluster have not previously been shown to be related to the initiation or progression of CLL. These novel findings provide fundamental information for further attempts to understand the interaction of the clustered genes in the leukomogenesis of CLL in order to better design treatments aimed at specific molecular target(s).
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
gene expression
deletion 11q23
CLL
Megjelenés:Leukemia. - 15 : 11 (2001), p. 1721-1728. -
További szerzők:El-Rifai, Wa'el Vilpo, L. Ollila, Juha Nagy Bálint (1956-) (molekuláris genetikus) Vihinen, Mauno Vilpo, Juhani Knuutila, Sakari
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2.

001-es BibID:BIBFORM065331
Első szerző:Ferrer, Anna
Cím:Different gene expression in immunoglobulin-mutated and immunoglobulin-unmutated forms of chronic lymphocytic leukemia / Anna Ferrer, Juha Ollila, Gerard Tobin, Bálint Nagy, Ulf Thunberg, Yan Aalto, Mauno Vihinen, Juhani Vilpo, Richard Rosenquist, Sakari Knuutila
Dátum:2004
ISSN:0165-4608
Megjegyzések:The mutation status of the immunoglobulin heavy chain variable regions (IgVH) has been found to be a good prognostic indicator for B-cell chronic lymphocytic leukemia (CLL) because unmutated VH genes are associated with rapid disease progression and shorter survival time. To study the differences in gene expression between the Ig-unmutated and Ig-mutated CLL subtypes, we performed gene expression profiling on 31 CLL cases and investigated the VH gene mutation status by sequencing. The array data showed that the greatest variances between the unmutated (20 cases) and the mutated (11 cases) group were in expressions of ZAP70, RAF1, PAX5, TCF1, CD44, SF1, S100A12, NUP214, DAF, GLVR1, MKK6, AF4, CX3CR1, NAFTC1, and HEX. ZAP70 was significantly more expressed in the Ig-unmutated CLL group, whereas the expression of all the other genes was higher in the Ig-mutated cases. These results corroborate a recent finding, according to which the expression of ZAP70 can predict the VH mutation status and suggest that RAF1, PAX5, and other differentially expressed genes may offer good markers for differentiating unmutated cases from mutated cases and thus serve as prognostic markers.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
gene
expression
immunoglobulin
mutated
unmutated
CLL
Megjelenés:Cancer Genetics And Cytogenetics. - 153 : 1 (2004), p. 69-72. -
További szerzők:Ollila, Juha Tobin, Gerard Nagy Bálint (1956-) (molekuláris genetikus) Thunberg, Ulf Aalto, Yan Vihinen, Mauno Vilpo, Juhani Rosenquist, Richard Knuutila, Sakari
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3.

001-es BibID:BIBFORM065340
Első szerző:Nagy Bálint (molekuláris genetikus)
Cím:Abnormal expression of apoptosis-related genes in haematological malignancies : overexpression of MYC is poor prognostic sign in mantle cell lymphoma / Bálint Nagy, Tuija Lundán, Marcelo L. Larramendy, Yan Aalto, Ying Zhu, Tarja Niini, Henrik Edgren, Anna Ferrer, Juhani Vilpo, Erkki Elonen, Kim Vettenranta, Kaarle Franssila, Sakari Knuutila
Dátum:2003
ISSN:0007-1048
Megjegyzések:The expression of apoptosis-related genes BCL2, BAX, BCL2L1, BCL2A1, MCL1, DAPK1 and MYC was studied by quantitative real-time polymerase chain reaction on total RNA samples from patients with acute lymphoblastic leukaemia (ALL, n = 16), acute myeloid leukaemia (AML, n = 27), chronic myeloid leukaemia (CML, n = 12), mantle cell lymphoma (MCL, n = 19) and chronic lymphoid leukaemia (CLL, n = 32). BCL2, BAX, BCL2A1, MCL1, DAPK1 and MYC were overexpressed in all patient groups. BCL2L1 was underexpressed in CLL and CML, but not in AML, ALL and MCL. MCL1 levels were significantly higher in CD13 and CD33-positive ALL, and in CD56-positive AML samples. BCL2, BCL2L1, BCL2A1 and MCL1 were overexpressed and DAPK1 was underexpressed in CLL samples with a 11q23 deletion. MYC overexpression was significantly associated with shorter overall survival in MCL (P < 0.01). AML patients with a normal karyotype showed a higher frequency of BCL2A1 overexpression (P < 0.001) than those with an abnormal karyotype.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
mantle cell
lymphoma
gene expression
myc
prognostic
Megjelenés:British Journal Of Haematology. - 120 (2003), p. 434-441. -
További szerzők:Lundán, Tuija Larramendy, Marcelo L. Aalto, Yan Zhu, Ying Niini, Tarja Edgren, Henrik Ferrer, Anna Vilpo, Juhani Elonen, Erkki Vettenranta, Kim Franssila, Kaarle Knuutila, Sakari
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4.

001-es BibID:BIBFORM065302
Első szerző:Nagy Bálint (molekuláris genetikus)
Cím:RAF-1 over-expression does condition survival of patients affected by aggressive mantle cell lymphoma / Nagy Bálint, Galimberti Sara, Benedetti Edoardo, Caracciolo Francesco, Pacini Simone, Vilpo Juhani, Ferrer Anna, Elonen Erkki, Franssila Kaarle, Knuutila Sakari, Petrini Mario
Dátum:2007
ISSN:0145-2126
Megjegyzések:Our results show over-expression of RAF-1 in MCL versus tonsilar B-cell population. The absence of significance versus normal bone marrows could be related to variability of neoplastic infiltration and, perhaps, to the microenvironment, that in MCL would be particularly relevant [11].The observation of a clinical prognostic significance of RAF-1 would be useful in the stratification of cases on the basis of a "biological risk".This would be particularly relevant in the context of the R-Hyper-CVAD regimen that, notwithstanding its high clinical efficacy (even in the eradicating minimal residual disease) has a not negligible toxicity (in our series, 30% of infective complications, with two patients who died because of sepsis).Consequently, if the prognostic role of RAF-1 over-expression will be confirmed in larger series of patients, different therapeutic strategies would be adopted in the treatment of MCL.In this line, Sorafenib, an oral multi-kinase inhibitor that targets also RAF kinases would be an interesting compound [12] for treatment of mantle cell lymphoma.
Tárgyszavak:Orvostudományok Klinikai orvostudományok levél
RAF-1
overexpression
mantle cell lymphoma
Megjelenés:Leukemia Research. - 31 : 11 (2007), p. 1595-1597. -
További szerzők:Galimberti, Sara Benedetti, Edoardo Caracciolo, Francesco Pacini, Simone Vilpo, Juhani Ferrer, Anna Elonen, Erkki Franssila, Kaarle Knuutila, Sakari Petrini, Mario
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5.

001-es BibID:BIBFORM065339
Első szerző:Nagy Bálint (molekuláris genetikus)
Cím:Lymphotoxin [béta] expression is high in chronic lymphocytic leukemia but low in small lymphocytic lymphoma : a quantitative real-time reverse transcriptase polymerase chain reaction analysis / Bálint Nagy, Anna Ferrer, Marcelo L. Larramendy, Sara Galimberti, Yan Aalto, Silvia Casas, Juhani Vilpo, Tapani Ruutu, Kim Vettenranta, Kaarle Franssila, Sakari Knuutila
Dátum:2003
ISSN:0390-6078
Megjegyzések:The lymphotoxin beta (LTB) gene, localized to the major histocompatibility complex region on chromosome 6p21.3, has an important role in the formation of germinal center reactions and regulation of immune response and apoptosis. Our aim was to determine LTB gene expression in different hematologic neoplasias. DESIGN AND METHODS: We determined the expression of LTB using quantitative real-time reverse transcriptase polymerase chain reaction (RT-PCR) on a series of RNA samples from CD3(+) T cells and CD19(+) B cells isolated from peripheral blood (n=7); CD19(+) B cells isolated from lymph nodes (n=11) and from patients with acute lymphoblastic leukemia (ALL; n=16), acute myeloid leukemia (AML; n=43), chronic myeloid leukemia (CML; n=12), mantle cell lymphoma (MCL; n=19), chronic lymphocytic leukemia (CLL; n=32) and small lymphocytic lymphoma (SLL; n=22). RESULTS: The expression level of LTB in CD3(+) T cells and CD19(+) B cells isolated from blood was ten to forty times lower than that in normal CD19(+) B cells isolated from lymph nodes. In malignant myeloid cells the expression levels were very low, whereas in malignant lymphoid cells the expression was higher than in myeloid cells, being highest in MCL and CLL (20.2+/-14.0 ng/microL and 81.0+/-116.3 ng/microL) and low in SLL (4.5+/-3.6 ng/microL; p=0.001). We did not find correlations between LTB expression and hematoclinical parameters (risk groups, immunophenotypes and overall survival). INTERPRETATION AND CONCLUSIONS: A distinct difference in expression of LTB in CLL and SLL indicates that these morphologically similar B-cell malignancies are molecularly different. Further studies are needed to investigate the prognostic value of LTB and any role that LTB may have in determining whether the malignant B cells manifest a leukemia or lymphoma.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
real-time
PCR
CLL
SLL
lyphotoxin
gene
expression
Megjelenés:Haematologica-The Hematology Journal. - 88 (2003), p. 654-658. -
További szerzők:Ferrer, Anna Larramendy, Marcelo L. Galimberti, Sara Aalto, Yan Casas, Silvia Vilpo, Juhani Ruutu, Tapani Vettenranta, Kim Franssila, Kaarle Knuutila, Sakari
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