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001-es BibID:	BIBFORM065340
Első szerző:	Nagy Bálint (molekuláris genetikus)
Cím:	Abnormal expression of apoptosis-related genes in haematological malignancies : overexpression of MYC is poor prognostic sign in mantle cell lymphoma / Bálint Nagy, Tuija Lundán, Marcelo L. Larramendy, Yan Aalto, Ying Zhu, Tarja Niini, Henrik Edgren, Anna Ferrer, Juhani Vilpo, Erkki Elonen, Kim Vettenranta, Kaarle Franssila, Sakari Knuutila
Dátum:	2003
ISSN:	0007-1048
Megjegyzések:	The expression of apoptosis-related genes BCL2, BAX, BCL2L1, BCL2A1, MCL1, DAPK1 and MYC was studied by quantitative real-time polymerase chain reaction on total RNA samples from patients with acute lymphoblastic leukaemia (ALL, n = 16), acute myeloid leukaemia (AML, n = 27), chronic myeloid leukaemia (CML, n = 12), mantle cell lymphoma (MCL, n = 19) and chronic lymphoid leukaemia (CLL, n = 32). BCL2, BAX, BCL2A1, MCL1, DAPK1 and MYC were overexpressed in all patient groups. BCL2L1 was underexpressed in CLL and CML, but not in AML, ALL and MCL. MCL1 levels were significantly higher in CD13 and CD33-positive ALL, and in CD56-positive AML samples. BCL2, BCL2L1, BCL2A1 and MCL1 were overexpressed and DAPK1 was underexpressed in CLL samples with a 11q23 deletion. MYC overexpression was significantly associated with shorter overall survival in MCL (P < 0.01). AML patients with a normal karyotype showed a higher frequency of BCL2A1 overexpression (P < 0.001) than those with an abnormal karyotype.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban mantle cell lymphoma gene expression myc prognostic
Megjelenés:	British Journal Of Haematology. - 120 (2003), p. 434-441. -
További szerzők:	Lundán, Tuija Larramendy, Marcelo L. Aalto, Yan Zhu, Ying Niini, Tarja Edgren, Henrik Ferrer, Anna Vilpo, Juhani Elonen, Erkki Vettenranta, Kim Franssila, Kaarle Knuutila, Sakari
Internet cím:	Szerző által megadott URL Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM065339
Első szerző:	Nagy Bálint (molekuláris genetikus)
Cím:	Lymphotoxin [béta] expression is high in chronic lymphocytic leukemia but low in small lymphocytic lymphoma : a quantitative real-time reverse transcriptase polymerase chain reaction analysis / Bálint Nagy, Anna Ferrer, Marcelo L. Larramendy, Sara Galimberti, Yan Aalto, Silvia Casas, Juhani Vilpo, Tapani Ruutu, Kim Vettenranta, Kaarle Franssila, Sakari Knuutila
Dátum:	2003
ISSN:	0390-6078
Megjegyzések:	The lymphotoxin beta (LTB) gene, localized to the major histocompatibility complex region on chromosome 6p21.3, has an important role in the formation of germinal center reactions and regulation of immune response and apoptosis. Our aim was to determine LTB gene expression in different hematologic neoplasias. DESIGN AND METHODS: We determined the expression of LTB using quantitative real-time reverse transcriptase polymerase chain reaction (RT-PCR) on a series of RNA samples from CD3(+) T cells and CD19(+) B cells isolated from peripheral blood (n=7); CD19(+) B cells isolated from lymph nodes (n=11) and from patients with acute lymphoblastic leukemia (ALL; n=16), acute myeloid leukemia (AML; n=43), chronic myeloid leukemia (CML; n=12), mantle cell lymphoma (MCL; n=19), chronic lymphocytic leukemia (CLL; n=32) and small lymphocytic lymphoma (SLL; n=22). RESULTS: The expression level of LTB in CD3(+) T cells and CD19(+) B cells isolated from blood was ten to forty times lower than that in normal CD19(+) B cells isolated from lymph nodes. In malignant myeloid cells the expression levels were very low, whereas in malignant lymphoid cells the expression was higher than in myeloid cells, being highest in MCL and CLL (20.2+/-14.0 ng/microL and 81.0+/-116.3 ng/microL) and low in SLL (4.5+/-3.6 ng/microL; p=0.001). We did not find correlations between LTB expression and hematoclinical parameters (risk groups, immunophenotypes and overall survival). INTERPRETATION AND CONCLUSIONS: A distinct difference in expression of LTB in CLL and SLL indicates that these morphologically similar B-cell malignancies are molecularly different. Further studies are needed to investigate the prognostic value of LTB and any role that LTB may have in determining whether the malignant B cells manifest a leukemia or lymphoma.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban real-time PCR CLL SLL lyphotoxin gene expression
Megjelenés:	Haematologica-The Hematology Journal. - 88 (2003), p. 654-658. -
További szerzők:	Ferrer, Anna Larramendy, Marcelo L. Galimberti, Sara Aalto, Yan Casas, Silvia Vilpo, Juhani Ruutu, Tapani Vettenranta, Kim Franssila, Kaarle Knuutila, Sakari
Internet cím:	Szerző által megadott URL Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM065344
Első szerző:	Niini, Tarja
Cím:	Expression of myeloid-specific genes in childhood acute lymphoblastic leukemia : a cDNA array study / T. Niini, K. Vettenranta, J. Hollmén, M. L. Larramendy, Y. Aalto, H. Wikman, B. Nagy, J. K. Seppänen, A. Ferrer Salvador, H. Mannila, U. M. Saarinen-Pihkala, S. Knuutila
Dátum:	2002
ISSN:	0887-6924
Megjegyzések:	Several specific cytogenetic changes are known to be associated with childhood acute lymphoblastic leukemia (ALL), and many of them are important prognostic factors for the disease. Little is known, however, about the changes in gene expression in ALL. Recently, the development of cDNA array technology has enabled the study of expression of hundreds to thousands of genes in a single experiment. We used the cDNA array method to study the gene expression profiles of 17 children with precursor-B ALL. Normal B cells from adenoids were used as reference material. We discuss the 25 genes that were most over-expressed compared to the reference. These included four genes that are normally expressed only in the myeloid lineages of the hematopoietic cells: RNASE2, GCSFR, PRTN3 and CLC. We also detected over-expression of S100A12, expressed in nerve cells but also in myeloid cells. In addition to the myeloid-specific genes, other over-expressed genes included AML1, LCP2 and FGF6. In conclusion, our study revealed novel information about gene expression in childhood ALL. The data obtained may contribute to further studies of the pathogenesis and prognosis of childhood ALL.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban expression gene myeloid ALL CDNA array
Megjelenés:	Leukemia. - 16 : 11 (2002), p. 2213-2221. -
További szerzők:	Vettenranta, Kim Hollmén, Jaakko Larramendy, Marcelo L. Aalto, Yan Wikman, Harriet Nagy Bálint (1956-) (molekuláris genetikus) Seppänen, Jouni K. Salvador, Aurora Ferrer Mannila, Heikki Saarinen-Pihkala, Ulla Maija Knuutila, Sakari
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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