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001-es BibID:	BIBFORM074846
Első szerző:	Heikinheimo, Kristiina
Cím:	Genetic changes in sporadic keratocystic odontogenic tumors (odontogenic keratocysts) / K. Heikinheimo, K. J. Jee, P. R. Morgan, B. Nagy, S. Knuutila, I. Leivo
Dátum:	2007
ISSN:	0022-0345
Megjegyzések:	Little is known about the genetic background of keratocystic odontogenic tumors (KCOT, odontogenic keratocysts). Our aim was to characterize genomic aberrations in sporadic KCOT using cDNA-expression arrays and array-comparative genomic hybridization. For cDNA-expression arrays, 10 KCOT specimens and 20 fetal tooth germs were studied. Quantitative real-time reverse-transcription/polymerase chain-reaction and immunohistochemical studies were also undertaken. Several genes were over-expressed in 12q13, including cytokeratin 6B (KRT6B) ( approximately 10-fold), epidermal growth factor receptor ERBB3 (approximately 4.7-fold), and glioma-associated oncogene homologue 1 (GLI1) (approximately 5- to 12-fold). One amplicon (approximately 0.7 Mega base pairs [Mbp]), covering several genes involved in the regulation of cell growth, was found in 12q13.2. Deletions were found in 3q13.1, 5p14.3, and 7q31.3, including the cell-adhesion-related gene cadherin 18 (CDH18) and leukocyte cell adhesion molecule (ALCAM, MEMD). Over-expressed and amplified genes in 12q13, also reported in several other tumors and cell lines, may contribute to the persistent growth characteristics of KCOT.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban odontogenic tumor genetic changes
Megjelenés:	Journal of Dental Research. - 86 : 6 (2007), p. 544-549. -
További szerzők:	Jee, Kowan Ja Morgan, Peter R. Nagy Bálint (1956-) (molekuláris genetikus) Knuutila, Sakari Leivo, Ilmo
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM065329
Első szerző:	Leivo, Ilmo
Cím:	Characterization of gene expression in major types of salivary gland carcinomas with epithelial differentiation / Ilmo Leivo, Kowan Ja Jee, Kristiina Heikinheimo, Merja Laine, Juha Ollila, Balint Nagy, Sakari Knuutil
Dátum:	2005
ISSN:	0165-4608
Megjegyzések:	Gene expression profiles were studied in 13 cases of salivary gland carcinoma including mucoepidermoid carcinoma (MEC), acinic cell carcinoma (ACC), and salivary duct carcinoma (SDC) using a cDNA array. A total of 162 genes were deregulated. Only 5 genes were overexpressed in all carcinomas including fibronectin 1 (FN1), tissue metalloproteinase inhibitor 1 (TIMP1), biglycan (BGN), tenascin-C (HXB), and insulin-like growth factor binding protein 5 (IGFBP5), whereas 16 genes were underexpressed. The small number of similarly deregulated genes in these carcinoma entities suggests an extensive genetic variation between them. This result agrees with the great histopathological diversity of different entities of salivary gland carcinoma. Furthermore, diversity in gene expression between the carcinoma types was identified also by hierarchical clustering. Each carcinoma entity was clustered together but MEC, SDC, and ACC were separated from each other. Significance analysis of microarrays identified 27 genes expressed differently between the groups. In MEC, overexpressed genes included those of cell proliferation (IL-6 and SFN) and cell adhesion (SEMA3F and COL6A3), whereas many underexpressed genes were related to DNA modification (NTHL1 and RBBP4). Apoptosis-related genes CASP10 and MMP11 were overexpressed in SDC, in accordance with the typical tumor necrosis seen in this entity. An intermediate filament protein of basal epithelial cells, cytokeratin 14 (KRT14) was clearly differently expressed between the 3 types of carcinoma, and can be used as an aid in their differential diagnosis. The array results were validated by RT-PCR and immunohistochemistry.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban gene expression salivary carcinomas epithelial
Megjelenés:	Cancer Genetics And Cytogenetics. - 156 : 2 (2005), p. 104-113. -
További szerzők:	Jee, Kowan Ja Heikinheimo, Kristiina Laine, Merja Ollila, Juha Nagy Bálint (1956-) (molekuláris genetikus) Knuutila, Sakari
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM065301
Első szerző:	Rautava, J.
Cím:	ERBB receptors in developing, dysplastic and malignant oral epithelia / J. Rautava, K. J. Jee, P. J. Miettinen, B. Nagy, S. Myllykangas, E. W. Odell, T. Soukka, P. R. Morgan, K. Heikinheimo
Dátum:	2008
ISSN:	1368-8375
Megjegyzések:	Some oral squamous cell carcinomas (OSCCs) overexpress epidermal growth factor receptor (EGFR) but little is known about the receptor system overall during oral carcinogenesis. We studied all four ERBB receptors (EGFR, ERBB2-4) in developing (n = 2), normal (n = 7), dysplastic (n = 23) and malignant (n = 26) oral epithelia by means of immunohistochemistry. The investigations were supplemented by conducting reverse transcription-polymerase chain reactions in relation to 13 OSCC samples. All four ERBB receptors were detected in developing oral epithelium and, to a lesser degree, in mature oral epithelium. An increase in EGFR immunoreactivity was seen in 61% and 54% of dysplasias and OSCCs, respectively. The corresponding percentages for ERBB2 were 48 and 12, for ERBB3 48 and 43. ERBB4 nuclear staining was increased in 30% of dysplasias and 26% of OSCCs. Changes in ERBB receptor mRNA levels were not statistically significant. The results show that ERBB receptor profiles are specific to each tumour. Increased nuclear translocation of ERBB4 in some OSCCs may alter transcription of target genes and be associated with cancer progression. This information may be useful for clinicians as EGFR inhibitors are becoming treatment options in modern oncology.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban ERBB Receptor oral Epithelial cancer
Megjelenés:	Oral Oncology. - 44 : 3 (2008), p. 227-235. -
További szerzők:	Jee, Kowan Ja Miettinen, Päivi J. Nagy Bálint (1956-) (molekuláris genetikus) Myllykangas, Samuel Odell, Edward William Soukka, Tero Morgan, Peter R. Heikinheimo, Kristiina
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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