CCL

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1.

001-es BibID:BIBFORM075323
Első szerző:Casas, Silvia
Cím:Aberrant expression of HOXA9, DEK, CBL and CSF1R in acute myeloid leukemia / Sílvia Casas, Bálint Nagy, Erkki Elonen, Anna Aventín, Marcelo L. Larramendy, Jorge Sierra, Tapani Ruutu, Sakari Knuutila
Dátum:2003
ISSN:1042-8194
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:Leukemia & Lymphoma. - 44 : 11 (2003), p. 1935-1941. -
További szerzők:Nagy Bálint (1956-) (molekuláris genetikus) Elonen, Erkki Aventín, Anna Larramendy, Marcelo L. Sierra, Jorge Ruutu, Tapani Knuutila, Sakari
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DOI
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2.

001-es BibID:BIBFORM065346
Első szerző:Larramendy, Marcelo L.
Cím:Overexpression of translocation-associated fusion genes of FGFRI, MYC, NPMI, and DEK, but absence of the translocations in acute myeloid leukemia : a microarray analysis. / Marcelo L. Larramendy, Tarja Niini, Erkki Elonen, Bálint Nagy, Juha Ollila, Mauno Vihinen, Sakari Knuutila
Dátum:2002
ISSN:0390-6078
Megjegyzések:BACKGROUND AND OBJECTIVES:Translocation-associated gene fusions are well recognized in acute myeloid leukemia. Other molecular genetic changes are less well known. The novel cDNA technology has opened the avenue to large-scale gene expression analysis. Our aim was to perform cDNA microarray analysis of acute myeloid leukemia (AML).DESIGN AND METHODS:We performed cDNA microarray analysis using the Clontech hematology filter (containing 406 genes) on 15 patients to study gene expression profiling in AML. As reference, we used whole bone marrow from 5 healthy donors.RESULTS:Our results revealed 50 differentially expressed genes in at least 3 out of 15 patients. Twenty-two genes were upregulated (ratio > or =4), whereas 28 genes were downregulated (ratio < or =0.25). All but one of the 13 genes tested by real-time polymerase chain reaction (PCR) showed the same expression profiles. Among the overexpressed genes, several were those earlier associated with chromosomal translocations and gene fusions. These genes were FGFR1, MYC, NPM1, DEC, and BCL2. The expression of two upregulated genes, HOXA4 and CSF1R, was significantly higher in patients with a white blood cell count higher than 30 x 10(9)/L cells. In patients whose white blood cell count was higher than 100 x 10(9)/L cells, both CLC and GRN were significantly underexpressed, whereas HOXA4 and DAPK1 were overexpressed. FGFR1 and CAMLG were more frequently significantly overexpressed in patients with CD56 immunophenoytpe.INTERPRETATION AND CONCLUSIONS:Clinical and prognostic significance of differential gene expression should be studied with a larger series of patients by using other techniques, such as quantitative real-time PCR.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
microarray
AML
FGFR1
MYC
DEK
NPMI
fusion genes
Megjelenés:Haematologica. - 87 (2002), p. 569-577. -
További szerzők:Niini, Tarja Elonen, Erkki Nagy Bálint (1956-) (molekuláris genetikus) Ollila, Juha Vihinen, Mauno Knuutila, Sakari
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3.

001-es BibID:BIBFORM065340
Első szerző:Nagy Bálint (molekuláris genetikus)
Cím:Abnormal expression of apoptosis-related genes in haematological malignancies : overexpression of MYC is poor prognostic sign in mantle cell lymphoma / Bálint Nagy, Tuija Lundán, Marcelo L. Larramendy, Yan Aalto, Ying Zhu, Tarja Niini, Henrik Edgren, Anna Ferrer, Juhani Vilpo, Erkki Elonen, Kim Vettenranta, Kaarle Franssila, Sakari Knuutila
Dátum:2003
ISSN:0007-1048
Megjegyzések:The expression of apoptosis-related genes BCL2, BAX, BCL2L1, BCL2A1, MCL1, DAPK1 and MYC was studied by quantitative real-time polymerase chain reaction on total RNA samples from patients with acute lymphoblastic leukaemia (ALL, n = 16), acute myeloid leukaemia (AML, n = 27), chronic myeloid leukaemia (CML, n = 12), mantle cell lymphoma (MCL, n = 19) and chronic lymphoid leukaemia (CLL, n = 32). BCL2, BAX, BCL2A1, MCL1, DAPK1 and MYC were overexpressed in all patient groups. BCL2L1 was underexpressed in CLL and CML, but not in AML, ALL and MCL. MCL1 levels were significantly higher in CD13 and CD33-positive ALL, and in CD56-positive AML samples. BCL2, BCL2L1, BCL2A1 and MCL1 were overexpressed and DAPK1 was underexpressed in CLL samples with a 11q23 deletion. MYC overexpression was significantly associated with shorter overall survival in MCL (P < 0.01). AML patients with a normal karyotype showed a higher frequency of BCL2A1 overexpression (P < 0.001) than those with an abnormal karyotype.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
mantle cell
lymphoma
gene expression
myc
prognostic
Megjelenés:British Journal Of Haematology. - 120 (2003), p. 434-441. -
További szerzők:Lundán, Tuija Larramendy, Marcelo L. Aalto, Yan Zhu, Ying Niini, Tarja Edgren, Henrik Ferrer, Anna Vilpo, Juhani Elonen, Erkki Vettenranta, Kim Franssila, Kaarle Knuutila, Sakari
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4.

001-es BibID:BIBFORM065302
Első szerző:Nagy Bálint (molekuláris genetikus)
Cím:RAF-1 over-expression does condition survival of patients affected by aggressive mantle cell lymphoma / Nagy Bálint, Galimberti Sara, Benedetti Edoardo, Caracciolo Francesco, Pacini Simone, Vilpo Juhani, Ferrer Anna, Elonen Erkki, Franssila Kaarle, Knuutila Sakari, Petrini Mario
Dátum:2007
ISSN:0145-2126
Megjegyzések:Our results show over-expression of RAF-1 in MCL versus tonsilar B-cell population. The absence of significance versus normal bone marrows could be related to variability of neoplastic infiltration and, perhaps, to the microenvironment, that in MCL would be particularly relevant [11].The observation of a clinical prognostic significance of RAF-1 would be useful in the stratification of cases on the basis of a "biological risk".This would be particularly relevant in the context of the R-Hyper-CVAD regimen that, notwithstanding its high clinical efficacy (even in the eradicating minimal residual disease) has a not negligible toxicity (in our series, 30% of infective complications, with two patients who died because of sepsis).Consequently, if the prognostic role of RAF-1 over-expression will be confirmed in larger series of patients, different therapeutic strategies would be adopted in the treatment of MCL.In this line, Sorafenib, an oral multi-kinase inhibitor that targets also RAF kinases would be an interesting compound [12] for treatment of mantle cell lymphoma.
Tárgyszavak:Orvostudományok Klinikai orvostudományok levél
RAF-1
overexpression
mantle cell lymphoma
Megjelenés:Leukemia Research. - 31 : 11 (2007), p. 1595-1597. -
További szerzők:Galimberti, Sara Benedetti, Edoardo Caracciolo, Francesco Pacini, Simone Vilpo, Juhani Ferrer, Anna Elonen, Erkki Franssila, Kaarle Knuutila, Sakari Petrini, Mario
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5.

001-es BibID:BIBFORM065342
Első szerző:Zhu, Ying
Cím:Investigatory and analytical approaches to differential gene expression profiling in mantle cell lymphoma / Ying Zhu, Jaakko Hollmén, Riikka Räty, Yan Aalto, Balint Nagy, Erkki Elonen, Juha Kere, Heikki Mannila, Kaarle Franssila, Sakari Knuutila
Dátum:2002
ISSN:0007-1048
Megjegyzések:Mantle cell lymphoma (MCL) is a non-Hodgkin's lymphoma of B-cell lineage. The blastoid variant of MCL, characterized by high mitotic rate, is clinically more aggressive than common MCL. We used the cDNA array technology to examine the gene expression profiles of both blastoid variant and common MCL. The data was analysed by regression analysis, principal component analysis and the naive Bayes' classifier. Eight genes were identified as differentially deregulated between the two groups. Oncogenes CMYC, BCL2 and PIM1 were upregulated more frequently in the blastoid variant than in common MCL. This implied that the gp130-mediated signal transducer and activator of transcription 3 (STAT3) signalling pathway was involved in the blastoid variant transformation of MCL. Other differentially deregulated genes were TOP1, CD23, CD45, CD70 and NFATC. By using the eight differentially deregulated genes, we created a classifier to distinguish the blastoid variant from common MCL with high accuracy. We also identified 18 genes that were deregulated in both groups. Among them, BCL1, CALLA/CD10 and GRN were suggested to be oncogenes. The products of RGS1, RGS2, ANX2 and CD44H were suggested to promote tumour metastasis. CD66D was suggested to be a tumour suppressor gene.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
gene
expression
mantle cell
lymphoma
Megjelenés:British Journal Of Haematology. - 119 (2002), p. 905-915. -
További szerzők:Hollmén, Jaakko Räty, Riikka Aalto, Yan Nagy Bálint (1956-) (molekuláris genetikus) Elonen, Erkki Kere, Juha Mannila, Heikki Franssila, Kaarle Knuutila, Sakari
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