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001-es BibID:	BIBFORM065332
Első szerző:	Savlı, Hakan
Cím:	Real-Time PCR analysis of af4 and dek genes expression in acute promyelocytic leukemia t (15; 17) patients / Hakan Savli, Sema Sirma, Balint Nagy, Melih Aktan, Guncag Dincol, Zafer Salcioglu, Nazan Sarper, Ugur Ozbek
Dátum:	2004
ISSN:	1226-3613
Megjegyzések:	Among several newly identified oncogenes, dek and af4 are attractive targets for researchers interested with leukemia. In this study quantitative Real-Time RT-PCR technique was used to define alterations in expression of dek and af4 genes associated with acute promyelocytic leukaemia (APL) t (15; 17). RNA samples obtained from bone marrow aspirates of fourteen APL patients, cDNA portions were labelled with Syber Green 1 dye and LightCycler analysis have been performed. Expression changes in patients were found not significant in comparison to healthy donors for af4 (P = 0.192) and dek (P = 0.0895). We suggest that af4 gene may have a role in leukomogenesis restricted to lymphoblastic lineage; also further studies must carry on with a larger series of patients in order to understand the relationship between the dek gene and APL. Our study was the first attempt for analysing dek and af4 genes in APL t (15; 17) patients by quantitative Real-Time RT-PCR. This rapid and sensitive method could be used to screen these genes in different types of leukaemia.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban real-time PCR AF4 DEK gene expression APL
Megjelenés:	Experimental And Molecular Medicine. - 36 : 3 (2004), p. 279-282. -
További szerzők:	Sirma, Sema Nagy Bálint (1956-) (molekuláris genetikus) Aktan, Melih Dincol, Guncag Salcioglu, Zafer Sarper, Nazan Ozbek, Ugur
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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