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001-es BibID:BIBFORM065423
Első szerző:Galimberti, Sara
Cím:Evaluation of the MDR1, ABCG2, Topoisomerases IIα and GST[pi] gene expression in patients affected by aggressive mantle cell lymphoma treated by the R-Hyper-CVAD regimen / Sara Galimberti, Balint Nagy, Edoardo Benedetti, Simone Pacini, Stefania Brizzi, Francesco Caracciolo, Federico Papineschi, Elena Ciabatti, Francesca Guerrini, Rita Fazzi, Martina Canestraro, Mario Petrini
Dátum:2009
ISSN:1042-8194
Megjegyzések:The genomic profile of mantle cell lymphoma (MCL) has been reported to be significantly different from that of otherindolent lymphoproliferative disorders, Topoisomerase IIa, glutathione-s-transferasep (GSTp) and ABCG2 (BCRP)chemoresistance genes being over-expressed in MCL. In our study, expression levels of the above mentioned genes plusMDR1 were tested on bone marrow samples from 20 patients treated with Rituximab plus hyper-CVAD regimen, in order toevaluate a possible impact of the chemoresistance phenomenon on this promising treatment regimen. All patients expressedABCG2 and MDR1 genes; 85% of cases expressed GSTp and topoisomerase IIa. Only ABCG2 were over-expressed incomparison both with marrow from healthy donors and tonsilar CD5?/CD20? lymphocytes (adopted as normal counterpart of the neoplastic population). The overall response rate of the entire series was 87.5%, with 44% of complete responses.Fifty-seven percent of patients achieved the clearance of minimal residual disease. Levels of tested genes did not condition either quality of clinical response or PFS (76% at 24 months). Nevertheless, an ABCG2 higher expression appeared associated with a worse PFS and levels of this gene paralleled the status of minimal residual disease. A further evaluation ofABCG2 expression in larger series of MCL patients would be suitable.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
MDR1
ABCG2
topoisomerases
mantle
cell
lymphoma
Megjelenés:Leukemia & Lymphoma. - 48 : 8 (2009), p. 1502-1509. -
További szerzők:Nagy Bálint (1956-) (molekuláris genetikus) Benedetti, Edoardo Pacini, Simone Brizzi, Stefania Caracciolo, Francesco Papineschi, Federico Ciabatti, Elena Guerrini, Francesca Fazzi, Rita Canestraro, Martina Petrini, Mario
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