Találati lista | Tudóstér

001-es BibID:	BIBFORM074858
Első szerző:	Aalto, Yan
Cím:	Distinct gene expression profiling in chronic lymphocytic leukemia with 11q23 deletion / Y. Aalto, W. El-Rifai, L. Vilpo, J. Ollila, B. Nagy, M. Vihinen, J. Vilpo, S. Knuutila
Dátum:	2001
ISSN:	0887-6924
Megjegyzések:	Chronic lymphocytic leukemia (CLL) is a heterogeneous disease with regard to its clinical course. The limitations of the methods currently available for prognostic assessment in CLL do not allow accurate prediction of the risk of disease progression in individual patients. The recently developed cDNA array technique provides a unique opportunity to study gene expression in various malignancies. To identify new molecular markers for prognostication of CLL patients, we analyzed cDNA arrays by using hierarchical clustering and standard statistic t-test on 34 CLL patients. We found significant expression differences in 78 genes compared to the reference tonsillar B lymphocytes. A cluster of genes, LCP1, PARP, BLR1, DEK, NPM, MCL1, SLP76, STAM, HIVEP1, EVI2B, CD25, HTLF, HIVEP2, BCL2, MNDA, PBX3, EB12, TCF1, CGRP, CD14, ILB, GZMK, GPR17 and CD79B, was associated (P < 0.05) with the unfavorable 11q deletion and also with the unfavorable Binet stages B and C. We present here gene expression profiling that is associated with CLL patients with the 11q23 deletion. Many of the genes in the cluster have not previously been shown to be related to the initiation or progression of CLL. These novel findings provide fundamental information for further attempts to understand the interaction of the clustered genes in the leukomogenesis of CLL in order to better design treatments aimed at specific molecular target(s).
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban gene expression deletion 11q23 CLL
Megjelenés:	Leukemia. - 15 : 11 (2001), p. 1721-1728. -
További szerzők:	El-Rifai, Wa'el Vilpo, L. Ollila, Juha Nagy Bálint (1956-) (molekuláris genetikus) Vihinen, Mauno Vilpo, Juhani Knuutila, Sakari
Internet cím:	Szerző által megadott URL Intézményi repozitóriumban (DEA) tárolt változat
Borító:
Saját polcon:

001-es BibID:	BIBFORM065335
Első szerző:	Varis, Asta
Cím:	Coamplified and overexpressed genes at erbb2 locus in gastric cancer / Asta Varis, Alexander Zaika, Pauli Puolakkainen, Balint Nagy, Irene Madrigal, Arto Kokkola, Aki Väyrynen, Päivi Karkkäinen, Christopher Moskaluk, Wa'el El-Rifai, Sakari Knuutila
Dátum:	2004
ISSN:	0020-7136
Megjegyzések:	DNA copy number amplification at the chromosomal region of 17q is frequent in gastric cancer. Recently 17q21 was identified as the critical region for the amplicon formation because this region harbors the ERBB2 oncogene and several other targets, such as TOP2A and DARPP32. In our study, we characterized the amplification (52 cases) and expression (29 cases) levels of ERBB2, TOP2A and DARPP32 in gastric cancer samples. These 3 genes were concomitantly amplified in 17% of the intestinal type of gastric adenocarcinoma. However, the expression levels were independent, showing overexpression of DARPP32 (48%), TOP2A (17%) and ERBB2 (3%) studied by quantitative real-time PCR. The most frequently overexpressed gene, DARPP32, exhibited strong protein overexpression in 45% (30/66) of the cases in immunohistochemical study of gastric cancer tumor tissue array. Additional studies are required to thoroughly understand the biological significance of these genes in gastric cancer.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban gastric cancer gene expression coamplification
Megjelenés:	International Journal Of Cancer. - 109 : 4 (2004), p. 548-553. -
További szerzők:	Zaika, Alexander Puolakkainen, Pauli Nagy Bálint (1956-) (molekuláris genetikus) Madrigal, Irene Kokkola, Arto Väyrynen, Aki Kärkkäinen, Päivi Moskaluk, Christopher El-Rifai, Wa'el Knuutila, Sakari
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
Borító:
Saját polcon: