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001-es BibID:BIBFORM065232
Első szerző:Molvarec Attila (szülész-nőgyógyász)
Cím:Circulating angiogenic factors determined by electrochemiluminescence immunoassay in relation to the clinical features and laboratory parameters in women with pre-eclampsia / Attila Molvarec, András Szarka, Szilvia Walentin, Endre Szűcs, Bálint Nagy, János Rigó Jr.
Dátum:2010
ISSN:0916-9636
Megjegyzések:The purpose of this study was to determine whether increased serum soluble fms-like tyrosine kinase-1 (sFlt-1) and decreasedplacental growth factor (PlGF) levels in pre-eclampsia are related to the clinical features and laboratory parameters of thepatients, including markers of inflammation, endothelial activation and injury, oxidative stress and trophoblast debris. A total of54 pre-eclamptic patients, 58 healthy pregnant and 52 healthy non-pregnant women were involved in this case?control study.Serum sFlt-1 and PlGF levels were measured by electrochemiluminescence immunoassay. Serum levels of sFlt-1 and PlGF weresignificantly higher in pre-eclamptic patients and healthy pregnant women than in healthy non-pregnant women. In addition,pre-eclamptic patients had significantly higher sFlt-1 levels and significantly lower PlGF concentrations compared with healthy pregnant women. According to the subgroup analyses, sFlt-1 levels were significantly higher in severely pre-eclamptic patients than in those with mild pre-eclampsia, whereas pre-eclamptic patients with fetal growth restriction or preterm onset of the disease had significantly lower PlGF concentrations compared with those without intrauterine growth restriction or with a diseaseonset at term. In the pre-eclamptic group, there were significant positive correlations between serum sFlt-1 levels and systolic and diastolic blood pressure, serum levels of blood urea nitrogen and creatinine, as well as plasma levels of von Willebrand factor antigen, fibronectin and cell-free fetal DNA. Furthermore, serum PlGF concentrations of pre-eclamptic patients showedsignificant positive correlations with gestational age at disease onset and delivery, as well as with fetal birth weight, and significant inverse correlations with levels of blood urea nitrogen, creatinine and fibronectin. In conclusion, increased serum sFlt-1 and decreased PlGF levels are associated with blood pressure, renal and endothelial dysfunction, trophoblast deportation, as well as with a shorter duration of pregnancy, fetal growth restriction, the severity and preterm onset of the disease in pre-eclampsia. These findings indicate the central role of an angiogenic imbalance in the pathogenesis of this pregnancy-specific disorde
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
circulating
Angiogenic
preeclampsia
factors
Megjelenés:Hypertension Research 33 : 9 (2010), p. 892-898. -
További szerzők:Szarka András Walentin Szilvia Szűcs Endre Nagy Bálint (1956-) (molekuláris genetikus) Rigó János (1958-) (szülész-nőgyógyász)
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2.

001-es BibID:BIBFORM065315
Első szerző:Molvarec Attila (szülész-nőgyógyász)
Cím:Lipid, haemostatic and inflammatory variables in relation to the estrogen receptor [alfa] (ESR1) PvuII and XbaI gene polymorphisms / Molvarec Attila, Nagy Bálint, Kovács Margit, Walentin Szilvia, Imreh Éva, Rigó János Jr., Szalay János, Füst George, Prohászka Zoltán, Karádi István
Dátum:2007
ISSN:0009-8981
Megjegyzések:Estrogen is known to affect lipoprotein metabolism, the haemostatic system and inflammatory markers. Our aim was to determine whether estrogen receptor alpha (ESR1) PvuII and XbaI gene polymorphisms can influence lipid, haemostatic and inflammatory variables in healthy Caucasian women and men of reproductive age.METHODS:58 healthy women (aged between 18 and 45 years) and 55 healthy men (aged between 21 and 45 years) of reproductive age were enrolled in our study. FSH levels, lipid (total cholesterol, triglyceride, HDL cholesterol, lipoprotein(a), apo A-I, apo B), haemostatic (prothrombin time, activated partial thromboplastin time (aPTT), thrombin time, fibrinogen, factor V, VII, VIII, protein C, protein S, antithrombin III) and inflammatory (CRP) variables were measured on autoanalyzers using commercially available kits. Serum VLDL and LDL cholesterol concentrations were calculated with the equation of Friedewald. The ESR1 PvuII and XbaI genotypes were determined with PCR-RFLP method.RESULTS:In the total group, the ESR1 XbaI GG genotype carriers had significantly higher serum lipoprotein(a) concentrations than the AA or AG genotype carriers. Serum total cholesterol concentrations were significantly higher in healthy women with the PvuII CC genotype than in those with the TT or TC genotypes, whereas healthy women with the GG genotype of the ESR1 XbaI polymorphism had significantly higher serum total cholesterol and LDL cholesterol levels compared to those with the AA or AG genotypes. No other effects of the ESR1 PvuII and XbaI polymorphisms were found on the investigated lipid, haemostatic and inflammatory variables either in the total group or in women and men separately.CONCLUSIONS:The ESR1 PvuII and XbaI gene polymorphisms seem to affect lipoprotein metabolism in healthy subjects of peak reproductive age. However, further studies are needed to determine the molecular mechanisms by which the two polymorphisms could influence serum lipid levels.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
lipid
estrogen receptor
inflammatory
gene
polymorphism
Megjelenés:Clinica Chimica Acta. - 380 : 1-2 (2007), p. 157-164. -
További szerzők:Nagy Bálint (1956-) (molekuláris genetikus) Kovács Margit (belgyógyász, Budapest) Walentin Szilvia Imreh Éva Rigó János (1958-) (szülész-nőgyógyász) Szalay János Füst György (Budapest) Prohászka Zoltán Karádi István (1952-) (belgyógyász, kardiológus)
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Intézményi repozitóriumban (DEA) tárolt változat
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3.

001-es BibID:BIBFORM065317
Első szerző:Molvarec Attila (szülész-nőgyógyász)
Cím:Serum heat shock protein 70 levels are decreased in normal human pregnancy / Molvarec Attila, Rigó János, Nagy Bálint, Walentin Szilvia, Szalay János, Füst George, Karádi István, Prohászka Zoltán
Dátum:2007
ISSN:0165-0378
Megjegyzések:Heat shock proteins (Hsps) are primarily known to be intracellular proteins with molecular chaperone and cytoprotective functions. However, Hsp60 and Hsp70 have been found in the serum and plasma of healthy non-pregnant individuals. We aimed to compare serum Hsp70 concentrations in healthy pregnant women with those of healthy non-pregnant women and to determine factors influencing serum Hsp70 levels in normal pregnancy. One hundred and seventy six healthy pregnant women with uncomplicated pregnancies (age, 17-44 years; gestational age, 20-41 weeks) and 81 healthy, age-matched non-pregnant women (age, 22-40 years) were enrolled in this cross-sectional study. Serum Hsp70 concentrations were measured using an enzyme-linked immunosorbent assay, and were significantly lower in healthy pregnant women than in healthy non-pregnant women (median (25-75 percentile): 0.29 (0.20-0.35)ng/ml versus 1.27 (0.86-1.72)ng/ml; p<0.001). In healthy pregnant women, there was a statistically significant negative correlation between maternal age and serum Hsp70 concentration (Spearman R=-0.35; p<0.001) and a significant positive correlation between gestational age and serum Hsp70 level (Spearman R=0.35; p<0.001). The capacity of extracellular Hsp70 to elicit innate and adaptive proinflammatory immune responses might be harmful in pregnancy and lead to immune rejection of the fetal semi-allograft. We hypothesize that decreased circulating Hsp70 levels are due to unknown regulatory mechanisms aimed at maintaining immune tolerance in pregnancy. In conclusion, serum Hsp70 concentrations are decreased in normal human pregnancy; however, further studies are needed to explain the observed differences between pregnant and non-pregnant women.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
serum
heat
schock
protein-70
decreased
Megjelenés:Journal Of Reproductive Immunology. - 74 : 1-2 (2007), p. 163-169. -
További szerzők:Rigó János (1958-) (szülész-nőgyógyász) Nagy Bálint (1956-) (molekuláris genetikus) Walentin Szilvia Szalay János Füst György (Budapest) Karádi István (1952-) (belgyógyász, kardiológus) Prohászka Zoltán
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DOI
Intézményi repozitóriumban (DEA) tárolt változat
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