CCL

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001-es BibID:BIBFORM065303
Első szerző:Sziller István (szülész-nőgyógyász szakorvos)
Cím:Chlamydia trachomatis infection, Fallopian tube damage and a mannose-binding lectin codon 54 gene polymorphism / I. Sziller, O. Babula, A. Ujházy, B. Nagy, P. Hupuczi, Z. Papp, I. M. Linhares, W. J. Ledger, S. S. Witkin
Dátum:2007
ISSN:0268-1161
Megjegyzések:Mannose-binding lectin (MBL), a component of the innate immune system, provides a first-line defense against invading microorganisms. Polymorphisms in the MBL gene have been associated with increased risk of infection. Chlamydia trachomatis genital tract infections are a major cause of Fallopian tube occlusion. Our objective was to test whether an MBL codon 54 polymorphism might contribute to development of C. trachomatis-associated tubal damage.METHODS:In a case-control study, 97 women with occluded and 104 women with patent Fallopian tubes were tested for a history of chlamydial infection by serology and for their MBL codon 54 genotype by PCR and restriction fragment length polymorphism analysis. Clinical data were blinded to those performing all laboratory analyses.RESULTS:Women with tubal occlusion who also had a positive chlamydial serology had the highest rate of variant MBL B allele carriage (P<0.001). Among women who were chlamydial antibody negative, allele B carriage was also more frequent in those with blocked, as opposed to patent, Fallopian tubes (P<0.01).CONCLUSIONS:Wild-type allele A homozygosity is protective against, while carriage of the variant allele B is a risk factor for, Fallopian tube occlusion in women who are seropositive or seronegative for C. trachomatis.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Chlamydia
trachomatis
mannose-binding
lectin
polymorphism
Megjelenés:Human Reproduction. - 22 : 7 (2007), p. 1861-1865. -
További szerzők:Babula, Oksana Ujházy A. Nagy Bálint (1956-) (molekuláris genetikus) Hupuczi Petronella (anaesthesiológus) Papp Zoltán (1942-) (szülész-nőgyógyász, genetikus) Linhares, Iara Moreno Ledger, William J. Witkin, Steven Sol
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2.

001-es BibID:BIBFORM065316
Első szerző:Sziller István (szülész-nőgyógyász szakorvos)
Cím:Mannose-binding lectin (MBL) codon 54 gene polymorphism protects against development of pre-eclampsia, HELLP syndrome and pre-eclampsia-associated intrauterine growth restriction / Sziller I., Babula O., Hupuczi P., Nagy B., Rigo B., Szabo G., Papp Z., Linhares I.M., Witkin S. S.
Dátum:2007
ISSN:1360-9947
Megjegyzések:Insufficient invasion of the spiral arteries by trophoblast cells is associated with the etiology of pre-eclampsia, the syndrome of hemolysis, elevated liver enzymes and low platelet counts (HELLP) and pre-eclampsia-associated intrauterine growth restriction (IUGR). Mannose-binding lectin (MBL) is a component of the innate immune system. MBL-mediated activation of the complement cascade is an important event in the destruction of invading trophoblasts. The gene coding for MBL is polymorphic, and variant alleles result in greatly reduced circulating MBL levels. The aim of this study was to test the association between an MBL polymorphism and pre-eclampsia, HELLP syndrome and IUGR. DNA was extracted from buccal swabs of 51 women with pre-eclampsia, 81 women with HELLP syndrome and 184 healthy pregnant controls. Aliquots were tested for a single nucleotide MBL gene polymorphism at codon 54 by PCR and endonuclease digestion. Homozygosity for the wild-type allele was more frequent in patients with pre-eclampsia (P = 0.04) and HELLP syndrome (P = 0.02) when compared with controls. The presence of the variant allele was more prevalent among controls than in women with pre-eclampsia (P = 0.02) or HELLP syndrome (P = 0.028). Twenty-two (55%) patients with pre-eclampsia and 43 (53%) women with HELLP syndrome delivered an IUGR neonate. MBL-54 heterozygosity was more frequent in controls (27.2%) than in pre-eclamptic women (4.5%, P = 0.025) and those with HELLP syndrome (11.7%, P = 0.05) who delivered an IUGR neonate. Genotype frequencies of neonates born to mothers in all study groups were similar. Carriage of the MBL codon 54 polymorphism protects against pre-eclampsia, HELLP syndrome and IUGR and implies that an MBL-mediated event might be involved in the pathogenesis of these disorders.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
mannose-binding
lectin
codon54
gene
polymorphism
Megjelenés:Molecular Human Reproduction. - 13 : 4 (2007), p. 281-285. -
További szerzők:Babula, Oksana Hupuczi Petronella (anaesthesiológus) Nagy Bálint (1956-) (molekuláris genetikus) Rigó Barbara (szülész-nőgyógyász) Szabó Gábor (budapesti orvos) Papp Zoltán (1942-) (szülész-nőgyógyász, genetikus) Linhares, Iara Moreno Witkin, Steven Sol
Internet cím:Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
Borító:
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